long-pepper - Gods

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Long Pepper

Ingredient · 10 compounds · 4 conditions

Long Pepper is profiled across the CytoSolve® knowledge base and mapped to the disease biology it influences — tracing each of its compounds through disease, biological process, molecular pathway and down to individual biomarkers, with source videos and references at each step.

Compounds in this ingredient

⌬Piperine ⌬Piperinic acid ⌬Piperlongumine ⌬Piperlonguminine ⌬Sesamin ⌬Stigmasterol ⌬α-Bisabolol ⌬α-Pinene ⌬β-Caryophyllene ⌬β-Sitosterol

Conditions addressed

❀Asthma ❀Bowel Health ❀Osteoarthritis ❀Viral Infections

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Ingredient → Compounds → Diseases → Biological Processes → Molecular Pathways → Biomarkers

All Compound Disease Biological Process Molecular Pathway

⌬

Compound · 4 disease(s) · 6 pathway(s)

▸

❀

Viral Infections

Disease · 3 process(es) · 3 pathway(s)

▸

▸✣ Apoptosis1 pathway

▸▣ Oxidative Stress Signaling

◈ TargetMitochondrial complex III◈ TargetNADPH Oxidase◈ TargetXanthine Oxidase

◆Cleaved PARP

▸✣ Inflammation1 pathway

▸▣ IL1β Signaling

◈ TargetAP-1

◆IL6, COX-2, PGE-2

▸✣ Cartilage Degeneration1 pathway

▸▣ IL1β Signaling

◈ TargetERK1/2

◆MMP1, MMP13

❀

Disease · 1 process(es) · 1 pathway(s)

▸

▸✣ Fibrosis1 pathway

▸▣ TGF-β/SMAD Signaling

◈ Targetp-SMAD2

◆N-cadherin, Fibronectin, MMP-2

❀

Disease · 1 process(es) · 1 pathway(s)

▸

▸✣ Inflammation1 pathway

▸▣ NF-κB Signaling

◈ TargetNF-κB

◆TNF-α, COX-2, claudin-1, occludin, and ZO-1

❀

Disease · 1 process(es) · 1 pathway(s)

▸

▸✣ Inflammation1 pathway

▸▣ IL-1β Signaling

◈ TargetNF-κB

◆MMP-3, MMP-13, iNOS and COX-2

⌬

Compound · 4 disease(s) · 6 pathway(s)

▸

❀

Viral Infections

Disease · 2 process(es) · 2 pathway(s)

▸

▸✣ Apoptosis1 pathway

▸▣ AKT Signaling

◈ TargetROS

◆Bcl-xL

▸✣ Inflammation1 pathway

▸▣ NF-κB Signaling

◈ TargetTNF-α

◆IL-6, IL-8, MMP-9, ICAM-1

❀

Disease · 1 process(es) · 1 pathway(s)

▸

▸✣ Apoptosis1 pathway

▸▣ RO-induced Apoptotic Signaling

◈ TargetROS

◆Caspase-3

❀

Disease · 2 process(es) · 2 pathway(s)

▸

▸✣ Cell Cycle Progression1 pathway

▸▣ JAK/STAT3 Signaling

◈ Targetp-JAK1/2

◆Cycin D

▸✣ Cell Cycle Invasion1 pathway

▸▣ JAK/STAT3 Signaling

◈ Targetp-JAK1/2

◆MMP-9, TWIST

❀

Disease · 1 process(es) · 1 pathway(s)

▸

▸✣ Osteoclastogenesis1 pathway

▸▣ RANKL Signaling

◈ TargetNF-κB

◆TNFα, IL-1β, IL-6, PGE-2

⌬

Piperlonguminine

Compound · 2 disease(s) · 4 pathway(s)

▸

❀

Viral Infections

Disease · 1 process(es) · 3 pathway(s)

▸

▸✣ Inflammation3 pathways

▸▣ TLR4/NF-κB Signaling

◈ TargetIκBα

◆p-IκBα

◈ Targetp65

◆p-p65

▸▣ NF-κB Signaling

◈ Targetp65

◆TNF-α, IL-6

▸▣ MAPK Signaling

◈ TargetERK/p38 MAPK

◆TNF-α, IL-6

❀

Disease · 1 process(es) · 1 pathway(s)

▸

▸✣ Apoptosis1 pathway

▸▣ NF-κB Signaling

◈ TargetNF-κB

◆Caspase-3, Caspase-9, BCL-2

⌬

Compound · 1 disease(s) · 1 pathway(s)

▸

❀

Viral Infections

Disease · 1 process(es) · 1 pathway(s)

▸

▸✣ Inflammation1 pathway

▸▣ LPS Signaling

◈ TargetiNOS

◆NO

⌬

β-Caryophyllene

Compound · 4 disease(s) · 5 pathway(s)

▸

❀

Viral Infections

Disease · 1 process(es) · 1 pathway(s)

▸

▸✣ Inflammation1 pathway

▸▣ Endocannabinoid Signaling

◈ TargetCB2R

◆IL-1β, IL-6, IFN-γ, and TNF-α

❀

Disease · 2 process(es) · 2 pathway(s)

▸

▸✣ Apoptosis1 pathway

▸▣ PI3K/AKT/mTOR Signaling

◈ TargetSTAT3

◆Caspase-3, Caspase-9, BCL-2

▸✣ Metastasis1 pathway

▸▣ VEGF/VEGFR2 Signaling

◈ TargetVEGF

◆VEGF

❀

Disease · 1 process(es) · 1 pathway(s)

▸

▸✣ Inflammation1 pathway

▸▣ CB2/PPAR-γ Signaling

◈ TargetCB2

◆FoxP3

❀

Disease · 1 process(es) · 1 pathway(s)

▸

▸✣ Inflammation1 pathway

▸▣ NLRP3 Signaling

◈ TargetNLRP3

◆IL-1β

⌬

Compound · 1 disease(s) · 1 pathway(s)

▸

❀

Disease · 1 process(es) · 1 pathway(s)

▸

▸✣ Apoptosis1 pathway

▸▣ PI3K/AKT Signalling

◈ TargetPI3K

◆Caspase-3, PI3K, AKT

⌬

Compound · 1 disease(s) · 1 pathway(s)

▸

❀

Disease · 1 process(es) · 1 pathway(s)

▸

▸✣ Autophagy1 pathway

▸▣ AKT/mTOR Signaling

◈ Targetp-AKT

◆p62, LC3-II

⌬

Compound · 1 disease(s) · 1 pathway(s)

▸

❀

Disease · 1 process(es) · 1 pathway(s)

▸

▸✣ Angiogenesis1 pathway

▸▣ NF-κB Signaling

◈ TargetCOX1

◆VEGF, FGF, PAI-1

⌬

Compound · 1 disease(s) · 1 pathway(s)

▸

❀

Disease · 1 process(es) · 1 pathway(s)

▸

▸✣ Chondroprotective1 pathway

▸▣ MMP Signaling

◈ TargetMMP-1◈ TargetMMP-3◈ TargetMMP-13

◆s-GAG, PG, hydroxyproline, Type II collagen

⌬

Compound · 1 disease(s) · 1 pathway(s)

▸

❀

Disease · 1 process(es) · 1 pathway(s)

▸

▸✣ Osteogenesis1 pathway

▸▣ TNFα Signaling

◈ Targetp-Smad1/5/9

◆Osteogenic markers such as BMP2, Dlx5, and Runx2