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Osteoarthritis
Disease / Phenomenon
A wear-associated joint condition in which cartilage gradually thins and the underlying bone remodels, leading to stiffness, discomfort, and reduced flexibility across the musculoskeletal system.
Biological Processes of Osteoarthritis
Explore the key biological processes that drive osteoarthritis, from cellular mechanisms through tissue-level responses.
Inflammation
23 pathway(s)
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Inflammation
23 pathway(s)
IL-1β/IL1R/COX-2 Signaling
Target: IKK
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IL-1β/IL1R/COX-2 Signaling
Target: IKK
COX-2
IL-1β Signaling
Target: NF-κB
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IL-1β Signaling
Target: NF-κB
COX-2
TNF-α Signaling
Target: NF-κB
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TNF-α Signaling
Target: NF-κB
IL-6
TNF-α
Bradykinin-induced COX-2 Signaling
Target: COX-2
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Bradykinin-induced COX-2 Signaling
Target: COX-2
COX-2
NF-κB/KPNA2/mIR1297 Signaling
Target: P65
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NF-κB/KPNA2/mIR1297 Signaling
Target: P65
JAK1/STAT3/HIF-1α Signaling
Target: JAK1
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JAK1/STAT3/HIF-1α Signaling
Target: JAK1
AMPK/MPAK/NF-κB Signaling
Target: p-JNK
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AMPK/MPAK/NF-κB Signaling
Target: p-JNK
NF-κB/MAPK Signaling
Target: p-p65
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NF-κB/MAPK Signaling
Target: p-p65
TNF-α
COX-2 Signaling
Target: COX-2
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COX-2 Signaling
Target: COX-2
COX-2
PI3K/AKT/NF-κB Signaling
Target: PPAR-γ
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PI3K/AKT/NF-κB Signaling
Target: PPAR-γ
IL-1/RANKL Signaling
Target: RANKL
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IL-1/RANKL Signaling
Target: RANKL
PGE2
NLRP3 Signaling
Target: NLRP3
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NLRP3 Signaling
Target: NLRP3
IL-1β
Cartilage Degeneration
12 pathway(s)
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Cartilage Degeneration
12 pathway(s)
IL-1β/p38 MAPK Signaling
Target: P-p38MAP
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IL-1β/p38 MAPK Signaling
Target: P-p38MAP
MMP13
TLR4/NF-κB Signaling
Target: MMP-1
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TLR4/NF-κB Signaling
Target: MMP-1
MMP-1
Cathepsin B Signaling
Target: Cathepsin B
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Cathepsin B Signaling
Target: Cathepsin B
Cathepsin B
JAK/STAT Signaling
Target: p-JAK3
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JAK/STAT Signaling
Target: p-JAK3
IL-1β
IL-1β/NF-κB Signaling
Target: NF-κB
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IL-1β/NF-κB Signaling
Target: NF-κB
iNOS and COX-2
Oxidative Stress
3 pathway(s)
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Oxidative Stress
3 pathway(s)
Cartilage Regeneration
1 pathway(s)
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Cartilage Regeneration
1 pathway(s)
IGF-1 Signaling
Target: Collagen II
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IGF-1 Signaling
Target: Collagen II
Collagen II
Osteoclastogenesis
3 pathway(s)
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Osteoclastogenesis
3 pathway(s)
Bone Degeneration
1 pathway(s)
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Bone Degeneration
1 pathway(s)
NF-κB Signaling
Target: NF-κB
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NF-κB Signaling
Target: NF-κB
iNOS
COX-2
IL-6
IL-β
Skeletal Muscal Atrophy
2 pathway(s)
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Skeletal Muscal Atrophy
2 pathway(s)
Osteogenesis
3 pathway(s)
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Osteogenesis
3 pathway(s)
p38 MAPKMAPK Signaling
Target: p-p38 MAPK
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p38 MAPKMAPK Signaling
Target: p-p38 MAPK
Chondroprotective
1 pathway(s)
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Chondroprotective
1 pathway(s)
Angiogenesis
1 pathway(s)
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Angiogenesis
1 pathway(s)
VEGF/VEGFR2 Signaling
Target: VEGFR2
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VEGF/VEGFR2 Signaling
Target: VEGFR2
VEGFR2
Compounds affecting Osteoarthritis
Browse active compounds and their direct impact on osteoarthritis biological processes, pathways, and biomarkers.
From Dried Ginger
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From Dried Ginger
From Dried Ginger
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From Dried Ginger
Inflammation
IL-1/RANKL Signaling
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Inflammation
IL-1/RANKL Signaling
PGE2
From Dried Ginger
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From Dried Ginger
From Dried Ginger
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From Dried Ginger
From Boswellia serrata
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From Boswellia serrata
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From Clove
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From Clove
From Delonix elata
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From Delonix elata
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From Black Pepper
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From Black Pepper
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Inflammation
Bradykinin-induced COX-2 Signaling
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Inflammation
Bradykinin-induced COX-2 Signaling
COX-2
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Inflammation
TNF-α Signaling
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Inflammation
TNF-α Signaling
IL-6
TNF-α
From Delonix elata
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From Delonix elata
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Osteoclastogenesis
RANK/RANKL Signaling
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Osteoclastogenesis
RANK/RANKL Signaling
Osteoprotegerin
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Cartilage Degeneration
TLR4/NF-κB Signaling
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Cartilage Degeneration
TLR4/NF-κB Signaling
MMP-1
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Osteoclastogenesis
NF-κB Signaling
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Osteoclastogenesis
NF-κB Signaling
NFATc1
TRAP
MMP-9
CTSK
From Black Pepper
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From Black Pepper
From Long Pepper
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From Long Pepper
Inflammation
IL-1β Signaling
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Inflammation
IL-1β Signaling
COX-2
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From Ashwagandha
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From Ashwagandha
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From Yucca
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From Yucca
From Chinese pistache
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From Chinese pistache
From Black Pepper
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From Black Pepper
From Long Pepper
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From Long Pepper
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Inflammation
COX-2 Signaling
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Inflammation
COX-2 Signaling
COX-2
From Clove
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From Clove
Inflammation
NF-κB/MAPK Signaling
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Inflammation
NF-κB/MAPK Signaling
TNF-α
From Ashwagandha
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From Ashwagandha
From Ashwagandha
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From Ashwagandha
From Ashwagandha
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From Ashwagandha
Cartilage Degeneration
Cathepsin B Signaling
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Cartilage Degeneration
Cathepsin B Signaling
Cathepsin B
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Bone Degeneration
NF-κB Signaling
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Bone Degeneration
NF-κB Signaling
iNOS
COX-2
IL-6
IL-β
From Long Pepper
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From Long Pepper
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Inflammation
NLRP3 Signaling
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Inflammation
NLRP3 Signaling
IL-1β
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Angiogenesis
VEGF/VEGFR2 Signaling
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Angiogenesis
VEGF/VEGFR2 Signaling
VEGFR2
Ingredients affecting Osteoarthritis
Explore therapeutic ingredients and their constituent compounds that modulate osteoarthritis biology.
0 active compound(s)
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0 active compound(s)
0 active compound(s)
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0 active compound(s)
1 active compound(s)
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1 active compound(s)
Cartilage Degeneration → IL-1β/p38 MAPK Signaling
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Cartilage Degeneration → IL-1β/p38 MAPK Signaling
MMP13
5 active compound(s)
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5 active compound(s)
Inflammation → NF-κB/KPNA2/mIR1297 Signaling
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Inflammation → NF-κB/KPNA2/mIR1297 Signaling
Inflammation → MAPK/NF-κB Signaling
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Inflammation → MAPK/NF-κB Signaling
Inflammation → JAK1/STAT3/HIF-1α Signaling
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Inflammation → JAK1/STAT3/HIF-1α Signaling
Inflammation → NF-κB/STAT3 Signlaing
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Inflammation → NF-κB/STAT3 Signlaing
4 active compound(s)
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4 active compound(s)
Inflammation → NLRP3 Signaling
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Inflammation → NLRP3 Signaling
IL-1β
Cartilage Degeneration → NF-κB Signaling
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Cartilage Degeneration → NF-κB Signaling
Skeletal Muscal Atrophy → ROS-mediated MAPK–MuRF-1 Signaling
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Skeletal Muscal Atrophy → ROS-mediated MAPK–MuRF-1 Signaling
1 active compound(s)
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1 active compound(s)
3 active compound(s)
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3 active compound(s)
Cartilage Degeneration → RhoA/ROCK Signaling
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Cartilage Degeneration → RhoA/ROCK Signaling
Cartilage Degeneration → NLRP3 Signaling
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Cartilage Degeneration → NLRP3 Signaling
Angiogenesis → VEGF/VEGFR2 Signaling
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Angiogenesis → VEGF/VEGFR2 Signaling
VEGFR2
3 active compound(s)
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3 active compound(s)
3 active compound(s)
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3 active compound(s)
Inflammation → NF-κB Signaling
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Inflammation → NF-κB Signaling
Inflammation → PGE2 Signaling
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Inflammation → PGE2 Signaling
4 active compound(s)
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4 active compound(s)
Inflammation → PI3K/AKT/NF-κB Signaling
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Inflammation → PI3K/AKT/NF-κB Signaling
Inflammation → IL-1/RANKL Signaling
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Inflammation → IL-1/RANKL Signaling
PGE2
Cartilage Degeneration → Nrf2 Signaling
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Cartilage Degeneration → Nrf2 Signaling
5 active compound(s)
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5 active compound(s)
Inflammation → TNF-α Signaling
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Inflammation → TNF-α Signaling
IL-6
TNF-α
Cartilage Degeneration → TLR4/NF-κB Signaling
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Cartilage Degeneration → TLR4/NF-κB Signaling
MMP-1
Osteoclastogenesis → RANK/RANKL Signaling
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Osteoclastogenesis → RANK/RANKL Signaling
Osteoprotegerin
Osteoclastogenesis → NF-κB Signaling
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Osteoclastogenesis → NF-κB Signaling
NFATc1
TRAP
MMP-9
CTSK
Bone Degeneration → NF-κB Signaling
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Bone Degeneration → NF-κB Signaling
iNOS
COX-2
IL-6
IL-β
0 active compound(s)
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0 active compound(s)
0 active compound(s)
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0 active compound(s)
3 active compound(s)
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3 active compound(s)
Inflammation → NF-κB/NLRP3 Signaling
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Inflammation → NF-κB/NLRP3 Signaling
Inflammation → AMPK/MPAK/NF-κB Signaling
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Inflammation → AMPK/MPAK/NF-κB Signaling
0 active compound(s)
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0 active compound(s)
0 active compound(s)
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0 active compound(s)
0 active compound(s)
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0 active compound(s)
2 active compound(s)
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2 active compound(s)
Inflammation → Arachidonic Acid Signaling
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Inflammation → Arachidonic Acid Signaling
Inflammation → Bradykinin-induced COX-2 Signaling
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Inflammation → Bradykinin-induced COX-2 Signaling
COX-2
4 active compound(s)
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4 active compound(s)
Osteoclastogenesis → RANKL Signaling
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Osteoclastogenesis → RANKL Signaling
Osteogenesis → TNFα Signaling
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Osteogenesis → TNFα Signaling
0 active compound(s)
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0 active compound(s)
1 active compound(s)
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1 active compound(s)
Inflammation → IL-1β/NF-κB Signaling
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Inflammation → IL-1β/NF-κB Signaling