asthma

Asthma - Gods
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Asthma

Disease / Phenomenon

A chronic airway condition in which the bronchial tubes become inflamed and hyper-reactive, narrowing in response to triggers and making breathing difficult in episodic flares.

Biological Processes of Asthma

Explore the key biological processes that drive asthma, from cellular mechanisms through tissue-level responses.

✣
Inflammation
29 pathway(s)
▸
▣
LPS/TLR4 Signaling
Target: NF-κB
▸
TNF-α and IL-1β
♧ Ingredient: Licorice ⌬ Compound: Licochalcone B
▶ Video
▣
IL-17 Signaling
Target: RORYT
▸
IL-17
♧ Ingredient: Licorice ⌬ Compound: 18β-Glycyrrhetinic Acid
▶ Video
RORYT
♧ Ingredient: Licorice ⌬ Compound: 18β-Glycyrrhetinic Acid
▶ Video
▣
NF-κB/ICAM-1 Signaling
Target: NF-κB
▸
NF-κB
♧ Ingredient: Bitter Gourd ⌬ Compound: Momordicoside G
▶ Video
ICAM-1
♧ Ingredient: Bitter Gourd ⌬ Compound: Momordicoside G
▶ Video
▣
NF-κB Signaling
Target: IκBα
▸
TNF-α
♧ Ingredient: Dried Ginger ⌬ Compound: Zingerone
▶ Video
▣
SOD/H2O2 Signaling
Target: O₂⁻
▸
SOD
♧ Ingredient: Eucalyptus ⌬ Compound: 1,8‑Cineole
H2O2
♧ Ingredient: Eucalyptus ⌬ Compound: 1,8‑Cineole
O₂⁻
♧ Ingredient: Eucalyptus ⌬ Compound: 1,8‑Cineole
▣
MAPK Signaling
Target: IL-1, IL-11
▸
IL-1
♧ Ingredient: Schisandra Fruit ⌬ Compound: Vitamin A
▶ Video
IL-8
♧ Ingredient: Schisandra Fruit ⌬ Compound: Vitamin A
▶ Video
▣
TNF-α Signalling
Target: TNF-α
▸
TNF-α
♧ Ingredient: Dong Quai ⌬ Compound: Ligustilide
▶ Video
▣
ERK/MAPK Signaling
Target: p-ERK
▸
ERK
♧ Ingredient: Ginkgo biloba ⌬ Compound: Ginkgolide B
▶ Video
TNF-α. IL-6
♧ Ingredient: Ginkgo biloba ⌬ Compound: Ginkgolide B
▶ Video
▣
cAMP/PKA Signaling
Target: A2A receptor
▸
IgG
♧ Ingredient: Black Cumin ⌬ Compound: Limonene
▶ Video
IgE
♧ Ingredient: Black Cumin ⌬ Compound: Limonene
▶ Video
IL-5
♧ Ingredient: Black Cumin ⌬ Compound: Limonene
▶ Video
▣
RIG-1 Signaling
Target: RIG-1
▸
TNF-α
♧ Ingredient: Black Cumin ⌬ Compound: ß-sitosterol
▶ Video
IL-4
♧ Ingredient: Black Cumin ⌬ Compound: ß-sitosterol
▶ Video
IL-5
♧ Ingredient: Black Cumin ⌬ Compound: ß-sitosterol
▶ Video
IL-13
♧ Ingredient: Black Cumin ⌬ Compound: ß-sitosterol
▶ Video
IL-21
♧ Ingredient: Black Cumin ⌬ Compound: ß-sitosterol
▶ Video
▣
TNF-α/NF-κB Signaling
Target: TNF-α
▸
IL-6
♧ Ingredient: Turmeric ⌬ Compound: Curcumin
▶ Video
IL-2
♧ Ingredient: Turmeric ⌬ Compound: Curcumin
▶ Video
IL-5
♧ Ingredient: Turmeric ⌬ Compound: Curcumin
▶ Video
GM-CSF
♧ Ingredient: Turmeric ⌬ Compound: Curcumin
▶ Video
▣
NRF2/Keap Signaling
Target: Nrf2
▸
SOD
♧ Ingredient: Astragalus ⌬ Compound: Calycosin
▶ Video
CAT
♧ Ingredient: Astragalus ⌬ Compound: Calycosin
▶ Video
▣
MCP-1/RANTES Signaling
Target: IL-13
▸
IL-13
♧ Ingredient: Garlic ⌬ Compound: S-allylcysteine
▶ Video
MCP-1
♧ Ingredient: Garlic ⌬ Compound: S-allylcysteine
▶ Video
RANTES
♧ Ingredient: Garlic ⌬ Compound: S-allylcysteine
▶ Video
▣
JAK2/NF-κB Signaling
Target: JAK2
▸
TNF-α
♧ Ingredient: Garlic ⌬ Compound: Kaempferol
▶ Video
▣
Arachidonic Acid Signaling
Target: PGE2
▸
PGE2
♧ Ingredient: Chinese Skullcap Root ⌬ Compound: Baicalein
▣
NLRP3 Signaling
Target: NLRP3
▸
IL-1β
♧ Ingredient: Dried Ginger ⌬ Compound: 10-Shogaol
▶ Video
Caspase-1
♧ Ingredient: Dried Ginger ⌬ Compound: 10-Shogaol
▶ Video
NLRP3
♧ Ingredient: Dried Ginger ⌬ Compound: 10-Shogaol
▶ Video
▣
TLR4/MyD88/NF-κB Signaling
Target: IκBα
▸
Collagen
♧ Ingredient: Dried Ginger ⌬ Compound: Gingerenone-A
▶ Video
E-cadherin
♧ Ingredient: Dried Ginger ⌬ Compound: Gingerenone-A
▶ Video
ß-catenin
♧ Ingredient: Dried Ginger ⌬ Compound: Gingerenone-A
▶ Video
▣
ACE2/MasR Signaling
Target: ACE2
▸
TNF-α
♧ Ingredient: Black Pepper ⌬ Compound: β-Caryophyllene
▶ Video
IL-1β
♧ Ingredient: Black Pepper ⌬ Compound: β-Caryophyllene
▶ Video
IL-6
♧ Ingredient: Black Pepper ⌬ Compound: β-Caryophyllene
▶ Video
▣
NF-κB/JAK 2 Signaling
Target: JAK 2
▸
IL-4
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Campesterol
▶ Video
IL-5
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Campesterol
▶ Video
AQP-1
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Campesterol
▶ Video
AQP-5
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Campesterol
▶ Video
▣
PI3K/AKT Signaling
Target: PI3K
▸
IL-6
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Chlorogenic acid
▶ Video
IL-1β
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Chlorogenic acid
▶ Video
TNFα
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Chlorogenic acid
▶ Video
IL-10
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Chlorogenic acid
▶ Video
▣
TLR4/MyD88 Signaling
Target: HSP70
▸
IL‑1ß
♧ Ingredient: Pricky brinjal Root ⌬ Compound: Dioscin
▶ Video
IL‑6
♧ Ingredient: Pricky brinjal Root ⌬ Compound: Dioscin
▶ Video
TNF‑α
♧ Ingredient: Pricky brinjal Root ⌬ Compound: Dioscin
▶ Video
▣
NF-κB/MAPK Signaling
Target: p38 MAPK
▸
IL-1β
♧ Ingredient: Pricky brinjal Root ⌬ Compound: Tomatidine
▶ Video
IL-6
♧ Ingredient: Pricky brinjal Root ⌬ Compound: Tomatidine
▶ Video
TNF-α
♧ Ingredient: Pricky brinjal Root ⌬ Compound: Tomatidine
▶ Video
▣
cAMP/Epac Signaling
Target: Epac
▸
TNF-α
♧ Ingredient: Pricky brinjal Root ⌬ Compound: Quercetin
▶ Video
IL-6
♧ Ingredient: Pricky brinjal Root ⌬ Compound: Quercetin
▶ Video
IL-1β
♧ Ingredient: Pricky brinjal Root ⌬ Compound: Quercetin
▶ Video
▣
HMGB-1/TLR4 Signalling
Target: HMGB-1
▸
TNF‐α
♧ Ingredient: Licorice ⌬ Compound: Glycyrrhizin
▶ Video
IL‐1β and IL‐6
♧ Ingredient: Licorice ⌬ Compound: Glycyrrhizin
▶ Video
▣
cAMP Signaling
Target: Adenylyl Cyclase (AC)
▸
cAMP Level
♧ Ingredient: Licorice ⌬ Compound: Liquiritigenin
▶ Video
▣
LPS Signaling
Target: TRPA1 Channel
▸
TNF-α
♧ Ingredient: Licorice ⌬ Compound: Liquiritin
▶ Video
IL-1β
♧ Ingredient: Licorice ⌬ Compound: Liquiritin
▶ Video
and IL-6
♧ Ingredient: Licorice ⌬ Compound: Liquiritin
▶ Video
▣
LPS/TLR Signaling
Target: p-JNK
▸
TNF-α
♧ Ingredient: Licorice ⌬ Compound: Liquiritin
▶ Video
and IL-6
♧ Ingredient: Licorice ⌬ Compound: Liquiritin
▶ Video
▣
FcεRI/Lyn + Syk/MAPK Signaling
Target: p-Lyn
▸
IL-4
♧ Ingredient: Adathoda-Leaf ⌬ Compound: Vasicine
▶ Video
IL-5
♧ Ingredient: Adathoda-Leaf ⌬ Compound: Vasicine
▶ Video
IL-9
♧ Ingredient: Adathoda-Leaf ⌬ Compound: Vasicine
▶ Video
and IL-13
♧ Ingredient: Adathoda-Leaf ⌬ Compound: Vasicine
▶ Video
▣
Th2 Signaling
Target: IL-13
▸
IL-4
♧ Ingredient: Adathoda-Leaf ⌬ Compound: Vasicolinone
▶ Video
✣
Epithelial-Mesenchymal Transition
3 pathway(s)
▸
▣
TGF-β Signaling
Target: TGF-β
▸
Collagen & α-SMA
♧ Ingredient: Licorice ⌬ Compound: Isoliquiritigenin
▶ Video
▣
TK-mediated Smad2 Signaling
Target: Guanidinoacetate Methyltransferase (GATM)
▸
E-cadherin
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Solasonine
▶ Video
N-cadherin
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Solasonine
▶ Video
▣
IL-6-induced STAT3/PD-L1 Signaling
Target: p-STAT3
▸
E-cadherin
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Solasonine
▶ Video
N-cadherin
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Solasonine
▶ Video
✣
Apoptosis
12 pathway(s)
▸
▣
ROS/Caspase-3 Signaling
Target: ROS
▸
ROS
♧ Ingredient: Bitter Gourd ⌬ Compound: Momordicoside G
▶ Video
P53
♧ Ingredient: Bitter Gourd ⌬ Compound: Momordicoside G
▶ Video
Caspase-3
♧ Ingredient: Bitter Gourd ⌬ Compound: Momordicoside G
▶ Video
▣
Caspase-3 Signaling
Target: Bcl-2
▸
BAX
♧ Ingredient: Oregano ⌬ Compound: Carvacrol
▶ Video
BCL-2
♧ Ingredient: Oregano ⌬ Compound: Carvacrol
▶ Video
Caspase-3
♧ Ingredient: Oregano ⌬ Compound: Carvacrol
▶ Video
▣
RO-induced Apoptotic Signaling
Target: ROS
▸
Caspase-3
♧ Ingredient: Long Pepper ⌬ Compound: Piperlongumine
▶ Video
▣
NF-κB Signaling
Target: NF-κB
▸
Caspase-3
♧ Ingredient: Long Pepper ⌬ Compound: Piperlonguminine
▶ Video
Caspase-9
♧ Ingredient: Long Pepper ⌬ Compound: Piperlonguminine
▶ Video
BCL-2
♧ Ingredient: Long Pepper ⌬ Compound: Piperlonguminine
▶ Video
▣
PI3K/AKT Signalling
Target: PI3K
▸
Caspase-3
♧ Ingredient: Long Pepper ⌬ Compound: α-Bisabolol
▶ Video
PI3K
♧ Ingredient: Long Pepper ⌬ Compound: α-Bisabolol
▶ Video
AKT
♧ Ingredient: Long Pepper ⌬ Compound: α-Bisabolol
▶ Video
▣
PI3K/AKT/mTOR Signaling
Target: STAT3
▸
Caspase-3
♧ Ingredient: Long Pepper ⌬ Compound: β-Caryophyllene
▶ Video
Caspase-9
♧ Ingredient: Long Pepper ⌬ Compound: β-Caryophyllene
▶ Video
BCL-2
♧ Ingredient: Long Pepper ⌬ Compound: β-Caryophyllene
▶ Video
▣
EGFR Signaling
Target: AKT
▸
p-AKT
♧ Ingredient: Dried Ginger ⌬ Compound: 6-Shogaol
▶ Video
Cleaved Caspase-3
♧ Ingredient: Dried Ginger ⌬ Compound: 6-Shogaol
▶ Video
▣
Caspase9/3 Signaling
Target: BAX/Bcl‐2
▸
BAX/Bcl‐2 ratio
♧ Ingredient: Black Pepper ⌬ Compound: α-Caryophyllene
▶ Video
Caspase-3
♧ Ingredient: Black Pepper ⌬ Compound: α-Caryophyllene
▶ Video
▣
Caspase Signaling
Target: Caspase-3
▸
ROS
♧ Ingredient: Black Pepper ⌬ Compound: Pinene
▶ Video
▣
Cytochrome C/Caspase-3 Signaling
Target: BCL-2
▸
BCL-2
♧ Ingredient: Adathoda-Leaf ⌬ Compound: Vasicinone
▶ Video
PARP
♧ Ingredient: Adathoda-Leaf ⌬ Compound: Vasicinone
▶ Video
▣
Fas Signaling
Target: Fas death receptor
▸
FasL
♧ Ingredient: Adathoda-Leaf ⌬ Compound: Vasicinone
▶ Video
▣
PI3K/AKT/mTOR/CD1 Signaling
Target: EGFR
▸
PARP1
♧ Ingredient: Adathoda-Leaf ⌬ Compound: β-Sitosterol
▶ Video
cleaved caspase-3
♧ Ingredient: Adathoda-Leaf ⌬ Compound: β-Sitosterol
▶ Video
BCL-2
♧ Ingredient: Adathoda-Leaf ⌬ Compound: β-Sitosterol
▶ Video
and BAX
♧ Ingredient: Adathoda-Leaf ⌬ Compound: β-Sitosterol
▶ Video
✣
Smooth Muscle Contraction
2 pathway(s)
▸
▣
RhoA/ROCK Signaling
Target: MAPK
▸
MAPK
♧ Ingredient: Schisandra ⌬ Compound: Schisantherin A
▶ Video
▣
Ca2+ Signaling
Target: MLCP
▸
MLCP
♧ Ingredient: Chinese Skullcap Root ⌬ Compound: Baicalin
✣
Mucus Hypersecretion
5 pathway(s)
▸
▣
Mucin Signaling
Target: Mucin 5
▸
Mucin 5
♧ Ingredient: Schisandra ⌬ Compound: Schisantherin A
▶ Video
▣
PKC/EGFR/ERK Signaling
Target: PKC
▸
PKC
♧ Ingredient: Turmeric ⌬ Compound: Quercetin
▶ Video
Mucin
♧ Ingredient: Turmeric ⌬ Compound: Quercetin
▶ Video
▣
CHOP/MUC5AC Signaling
Target: ER stress/CHOP
▸
Mucin 5
♧ Ingredient: Astragalus ⌬ Compound: Astragaloside IV
▶ Video
CHOP
♧ Ingredient: Astragalus ⌬ Compound: Astragaloside IV
▶ Video
▣
IL-13 Signaling
Target: IL-13
▸
IL-13
♧ Ingredient: Astragalus ⌬ Compound: Baicalein
▶ Video
Mucin-5
♧ Ingredient: Astragalus ⌬ Compound: Baicalein
▶ Video
▣
EGFR Signaling
Target: Mucin 5
▸
Mucin 5
♧ Ingredient: Dong Quai Root ⌬ Compound: Ligustilide
✣
Fibrosis
5 pathway(s)
▸
▣
TGF-β/AKT/mTOR Signaling
Target: TGF-β
▸
IL-6
♧ Ingredient: Ginkgo biloba ⌬ Compound: Quercetin
▶ Video
IL-8
♧ Ingredient: Ginkgo biloba ⌬ Compound: Quercetin
▶ Video
COL-1
♧ Ingredient: Ginkgo biloba ⌬ Compound: Quercetin
▶ Video
COL-3
♧ Ingredient: Ginkgo biloba ⌬ Compound: Quercetin
▶ Video
VEGF
♧ Ingredient: Ginkgo biloba ⌬ Compound: Quercetin
▶ Video
▣
TGF-β Signaling
Target: TGF-β
▸
E-cadherin
♧ Ingredient: Black Cumin ⌬ Compound: ß-sitosterol
▶ Video
Vimentin
♧ Ingredient: Black Cumin ⌬ Compound: ß-sitosterol
▶ Video
α-SMA
♧ Ingredient: Black Cumin ⌬ Compound: ß-sitosterol
▶ Video
▣
Inflammatory Signaling
Target: IL-1β, TNF-α
▸
IL-1β
♧ Ingredient: Red Sage ⌬ Compound: Salvianolic acid B
▶ Video
TNF-α
♧ Ingredient: Red Sage ⌬ Compound: Salvianolic acid B
▶ Video
▣
TGF-β/SMAD Signaling
Target: TGF-β1
▸
N-cadherin
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Solasodine
▶ Video
Fibronectin
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Solasodine
▶ Video
MMP-2
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Solasodine
▶ Video
▣
TGF-β1 Signaling
Target: SIRT1
▸
α-SMA
♧ Ingredient: Dried Ginger ⌬ Compound: 6-Gingerol
▶ Video
Collagen IV
♧ Ingredient: Dried Ginger ⌬ Compound: 6-Gingerol
▶ Video
✣
Bronchodilation
1 pathway(s)
▸
▣
PDE4/PKC/Ca2+ Signaling
Target: PDE4
▸
Ca2+ level
♧ Ingredient: Ginger ⌬ Compound: 6-Gingerol
▶ Video
✣
Bronchoconstriction
2 pathway(s)
▸
▣
NF-κB Signaling
Target: NF-κB
▸
IgG
♧ Ingredient: Garlic ⌬ Compound: Vitamin E
▶ Video
▣
Arachidonic Acid Signaling
Target: COX-2
▸
COX-2
♧ Ingredient: Garlic ⌬ Compound: Kaempferol
▶ Video
PDF2
♧ Ingredient: Garlic ⌬ Compound: Kaempferol
▶ Video
PDF2α
♧ Ingredient: Garlic ⌬ Compound: Kaempferol
▶ Video
✣
Metastasis
1 pathway(s)
▸
▣
VEGF/VEGFR2 Signaling
Target: VEGF
▸
VEGF
♧ Ingredient: Long Pepper ⌬ Compound: β-Caryophyllene
▶ Video
✣
Cell Cycle Progression
1 pathway(s)
▸
▣
EGFR Signaling
Target: AKT
▸
p-AKT
♧ Ingredient: Dried Ginger ⌬ Compound: 6-Shogaol
▶ Video
Cyclin D1/3
♧ Ingredient: Dried Ginger ⌬ Compound: 6-Shogaol
▶ Video
✣
Oxidative Stress
2 pathway(s)
▸
▣
AMPK/Nrf2/HO-1 Signaling
Target: p-AMPK
▸
ROS
♧ Ingredient: Dried Ginger ⌬ Compound: Zingerone
▶ Video
HO-1
♧ Ingredient: Dried Ginger ⌬ Compound: Zingerone
▶ Video
▣
Nrf2 Signaling
Target: Nrf2
▸
MPO
♧ Ingredient: Black Pepper ⌬ Compound: β-Caryophyllene
▶ Video
GPx
♧ Ingredient: Black Pepper ⌬ Compound: β-Caryophyllene
▶ Video
MDA
♧ Ingredient: Black Pepper ⌬ Compound: β-Caryophyllene
▶ Video
ROS
♧ Ingredient: Black Pepper ⌬ Compound: β-Caryophyllene
▶ Video
✣
Tissue Remodelling
1 pathway(s)
▸
▣
Wnt/β-catenin Signaling
Target: β-catenin
▸
Collagen
♧ Ingredient: Dried Ginger ⌬ Compound: Gingerenone-A
▶ Video
E-cadherin
♧ Ingredient: Dried Ginger ⌬ Compound: Gingerenone-A
▶ Video
ß-catenin
♧ Ingredient: Dried Ginger ⌬ Compound: Gingerenone-A
▶ Video
✣
Cell Proliferation
2 pathway(s)
▸
▣
p21/cyclin D Signaling
Target: p21
▸
p21
♧ Ingredient: Black Pepper ⌬ Compound: α-Caryophyllene
▶ Video
cyclin E2
♧ Ingredient: Black Pepper ⌬ Compound: α-Caryophyllene
▶ Video
CDK4
♧ Ingredient: Black Pepper ⌬ Compound: α-Caryophyllene
▶ Video
CDK2
♧ Ingredient: Black Pepper ⌬ Compound: α-Caryophyllene
▶ Video
CDK6
♧ Ingredient: Black Pepper ⌬ Compound: α-Caryophyllene
▶ Video
and cyclin D3
♧ Ingredient: Black Pepper ⌬ Compound: α-Caryophyllene
▶ Video
▣
STAT1 Signaling
Target: p-STAT1
▸
p-STAT1
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Solamargine
▶ Video
PD-L1
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Solamargine
▶ Video
and apoptosis index proteins
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Solamargine
▶ Video
✣
Neutrophil Infiltration
1 pathway(s)
▸
▣
ß2-integrin mediated Signaling
Target: ß2-Integrin
▸
TNF-α
♧ Ingredient: Black Pepper ⌬ Compound: Limonene
▶ Video
IL-1β
♧ Ingredient: Black Pepper ⌬ Compound: Limonene
▶ Video
IL-6
♧ Ingredient: Black Pepper ⌬ Compound: Limonene
▶ Video
✣
Airway Hyperresponsiveness
1 pathway(s)
▸
▣
Ova-induced Th2 Signaling
Target: IL-5R
▸
IL-4
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Solasodine
▶ Video
TNF-α
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Solasodine
▶ Video
IL-1β
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Solasodine
▶ Video
✣
Chemoresistance
1 pathway(s)
▸
▣
P-gp-Mediated Drug efflux Signaling
Target: P-glycoprotein
▸
P-gp
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Solamargine
▶ Video
✣
Angiogenesis
1 pathway(s)
▸
▣
HIF-1α Signaling
Target: VEGF
▸
VEGF
♧ Ingredient: Pricky brinjal Root ⌬ Compound: Apigenin
▶ Video
✣
Platelet Aggregation
1 pathway(s)
▸
▣
PI3K/AKT/GSK3ß Signaling
Target: NF-κB
▸
P-selectin
♧ Ingredient: Licorice ⌬ Compound: Glabridin
▶ Video

Compounds affecting Asthma

Browse active compounds and their direct impact on asthma biological processes, pathways, and biomarkers.

⌬
▸
✣
Inflammation
SOD/H2O2 Signaling
▸
SOD
♧ Ingredient: Eucalyptus ⌬ Compound: 1,8‑Cineole
H2O2
♧ Ingredient: Eucalyptus ⌬ Compound: 1,8‑Cineole
O₂⁻
♧ Ingredient: Eucalyptus ⌬ Compound: 1,8‑Cineole
⌬
▸
✣
Inflammation
NLRP3 Signaling
▸
IL-1β
♧ Ingredient: Dried Ginger ⌬ Compound: 10-Shogaol
▶ Video
Caspase-1
♧ Ingredient: Dried Ginger ⌬ Compound: 10-Shogaol
▶ Video
NLRP3
♧ Ingredient: Dried Ginger ⌬ Compound: 10-Shogaol
▶ Video
⌬
▸
✣
Inflammation
IL-17 Signaling
▸
IL-17
♧ Ingredient: Licorice ⌬ Compound: 18β-Glycyrrhetinic Acid
▶ Video
RORYT
♧ Ingredient: Licorice ⌬ Compound: 18β-Glycyrrhetinic Acid
▶ Video
⌬
▸
✣
Fibrosis
TGF-β1 Signaling
▸
α-SMA
♧ Ingredient: Dried Ginger ⌬ Compound: 6-Gingerol
▶ Video
Collagen IV
♧ Ingredient: Dried Ginger ⌬ Compound: 6-Gingerol
▶ Video
✣
Bronchodilation
PDE4/PKC/Ca2+ Signaling
▸
Ca2+ level
♧ Ingredient: Ginger ⌬ Compound: 6-Gingerol
▶ Video
⌬
▸
✣
Apoptosis
EGFR Signaling
▸
p-AKT
♧ Ingredient: Dried Ginger ⌬ Compound: 6-Shogaol
▶ Video
Cleaved Caspase-3
♧ Ingredient: Dried Ginger ⌬ Compound: 6-Shogaol
▶ Video
✣
Cell Cycle Progression
EGFR Signaling
▸
p-AKT
♧ Ingredient: Dried Ginger ⌬ Compound: 6-Shogaol
▶ Video
Cyclin D1/3
♧ Ingredient: Dried Ginger ⌬ Compound: 6-Shogaol
▶ Video
⌬
▸
✣
Angiogenesis
HIF-1α Signaling
▸
VEGF
♧ Ingredient: Pricky brinjal Root ⌬ Compound: Apigenin
▶ Video
⌬
▸
✣
Mucus Hypersecretion
CHOP/MUC5AC Signaling
▸
Mucin 5
♧ Ingredient: Astragalus ⌬ Compound: Astragaloside IV
▶ Video
CHOP
♧ Ingredient: Astragalus ⌬ Compound: Astragaloside IV
▶ Video
⌬
▸
✣
Inflammation
Arachidonic Acid Signaling
▸
PGE2
♧ Ingredient: Chinese Skullcap Root ⌬ Compound: Baicalein
✣
Mucus Hypersecretion
IL-13 Signaling
▸
IL-13
♧ Ingredient: Astragalus ⌬ Compound: Baicalein
▶ Video
Mucin-5
♧ Ingredient: Astragalus ⌬ Compound: Baicalein
▶ Video
⌬
▸
✣
Smooth Muscle Contraction
Ca2+ Signaling
▸
MLCP
♧ Ingredient: Chinese Skullcap Root ⌬ Compound: Baicalin
⌬
▸
✣
Inflammation
NRF2/Keap Signaling
▸
SOD
♧ Ingredient: Astragalus ⌬ Compound: Calycosin
▶ Video
CAT
♧ Ingredient: Astragalus ⌬ Compound: Calycosin
▶ Video
⌬
▸
✣
Inflammation
NF-κB/JAK 2 Signaling
▸
IL-4
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Campesterol
▶ Video
IL-5
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Campesterol
▶ Video
AQP-1
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Campesterol
▶ Video
AQP-5
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Campesterol
▶ Video
⌬
▸
✣
Apoptosis
Caspase-3 Signaling
▸
BAX
♧ Ingredient: Oregano ⌬ Compound: Carvacrol
▶ Video
BCL-2
♧ Ingredient: Oregano ⌬ Compound: Carvacrol
▶ Video
Caspase-3
♧ Ingredient: Oregano ⌬ Compound: Carvacrol
▶ Video
⌬
▸
✣
Inflammation
PI3K/AKT Signaling
▸
IL-6
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Chlorogenic acid
▶ Video
IL-1β
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Chlorogenic acid
▶ Video
TNFα
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Chlorogenic acid
▶ Video
IL-10
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Chlorogenic acid
▶ Video
⌬
▸
✣
Inflammation
TNF-α/NF-κB Signaling
▸
IL-6
♧ Ingredient: Turmeric ⌬ Compound: Curcumin
▶ Video
IL-2
♧ Ingredient: Turmeric ⌬ Compound: Curcumin
▶ Video
IL-5
♧ Ingredient: Turmeric ⌬ Compound: Curcumin
▶ Video
GM-CSF
♧ Ingredient: Turmeric ⌬ Compound: Curcumin
▶ Video
⌬
▸
✣
Inflammation
TLR4/MyD88 Signaling
▸
IL‑1ß
♧ Ingredient: Pricky brinjal Root ⌬ Compound: Dioscin
▶ Video
IL‑6
♧ Ingredient: Pricky brinjal Root ⌬ Compound: Dioscin
▶ Video
TNF‑α
♧ Ingredient: Pricky brinjal Root ⌬ Compound: Dioscin
▶ Video
⌬
▸
✣
Inflammation
TLR4/MyD88/NF-κB Signaling
▸
Collagen
♧ Ingredient: Dried Ginger ⌬ Compound: Gingerenone-A
▶ Video
E-cadherin
♧ Ingredient: Dried Ginger ⌬ Compound: Gingerenone-A
▶ Video
ß-catenin
♧ Ingredient: Dried Ginger ⌬ Compound: Gingerenone-A
▶ Video
✣
Tissue Remodelling
Wnt/β-catenin Signaling
▸
Collagen
♧ Ingredient: Dried Ginger ⌬ Compound: Gingerenone-A
▶ Video
E-cadherin
♧ Ingredient: Dried Ginger ⌬ Compound: Gingerenone-A
▶ Video
ß-catenin
♧ Ingredient: Dried Ginger ⌬ Compound: Gingerenone-A
▶ Video
⌬
▸
✣
Inflammation
ERK/MAPK Signaling
▸
ERK
♧ Ingredient: Ginkgo biloba ⌬ Compound: Ginkgolide B
▶ Video
TNF-α. IL-6
♧ Ingredient: Ginkgo biloba ⌬ Compound: Ginkgolide B
▶ Video
⌬
▸
✣
Platelet Aggregation
PI3K/AKT/GSK3ß Signaling
▸
P-selectin
♧ Ingredient: Licorice ⌬ Compound: Glabridin
▶ Video
⌬
▸
✣
Inflammation
HMGB-1/TLR4 Signalling
▸
TNF‐α
♧ Ingredient: Licorice ⌬ Compound: Glycyrrhizin
▶ Video
IL‐1β and IL‐6
♧ Ingredient: Licorice ⌬ Compound: Glycyrrhizin
▶ Video
⌬
▸
✣
Epithelial-Mesenchymal Transition
TGF-β Signaling
▸
Collagen & α-SMA
♧ Ingredient: Licorice ⌬ Compound: Isoliquiritigenin
▶ Video
⌬
▸
✣
Inflammation
JAK2/NF-κB Signaling
▸
TNF-α
♧ Ingredient: Garlic ⌬ Compound: Kaempferol
▶ Video
✣
Bronchoconstriction
Arachidonic Acid Signaling
▸
COX-2
♧ Ingredient: Garlic ⌬ Compound: Kaempferol
▶ Video
PDF2
♧ Ingredient: Garlic ⌬ Compound: Kaempferol
▶ Video
PDF2α
♧ Ingredient: Garlic ⌬ Compound: Kaempferol
▶ Video
⌬
▸
✣
Inflammation
LPS/TLR4 Signaling
▸
TNF-α and IL-1β
♧ Ingredient: Licorice ⌬ Compound: Licochalcone B
▶ Video
⌬
▸
✣
Inflammation
TNF-α Signalling
▸
TNF-α
♧ Ingredient: Dong Quai ⌬ Compound: Ligustilide
▶ Video
✣
Mucus Hypersecretion
EGFR Signaling
▸
Mucin 5
♧ Ingredient: Dong Quai Root ⌬ Compound: Ligustilide
⌬
▸
✣
Inflammation
cAMP/PKA Signaling
▸
IgG
♧ Ingredient: Black Cumin ⌬ Compound: Limonene
▶ Video
IgE
♧ Ingredient: Black Cumin ⌬ Compound: Limonene
▶ Video
IL-5
♧ Ingredient: Black Cumin ⌬ Compound: Limonene
▶ Video
✣
Neutrophil Infiltration
ß2-integrin mediated Signaling
▸
TNF-α
♧ Ingredient: Black Pepper ⌬ Compound: Limonene
▶ Video
IL-1β
♧ Ingredient: Black Pepper ⌬ Compound: Limonene
▶ Video
IL-6
♧ Ingredient: Black Pepper ⌬ Compound: Limonene
▶ Video
⌬
▸
✣
Inflammation
cAMP Signaling
▸
cAMP Level
♧ Ingredient: Licorice ⌬ Compound: Liquiritigenin
▶ Video
⌬
▸
✣
Inflammation
LPS Signaling
▸
TNF-α
♧ Ingredient: Licorice ⌬ Compound: Liquiritin
▶ Video
IL-1β
♧ Ingredient: Licorice ⌬ Compound: Liquiritin
▶ Video
and IL-6
♧ Ingredient: Licorice ⌬ Compound: Liquiritin
▶ Video
✣
Inflammation
LPS/TLR Signaling
▸
TNF-α
♧ Ingredient: Licorice ⌬ Compound: Liquiritin
▶ Video
and IL-6
♧ Ingredient: Licorice ⌬ Compound: Liquiritin
▶ Video
⌬
▸
✣
Inflammation
NF-κB/ICAM-1 Signaling
▸
NF-κB
♧ Ingredient: Bitter Gourd ⌬ Compound: Momordicoside G
▶ Video
ICAM-1
♧ Ingredient: Bitter Gourd ⌬ Compound: Momordicoside G
▶ Video
✣
Apoptosis
ROS/Caspase-3 Signaling
▸
ROS
♧ Ingredient: Bitter Gourd ⌬ Compound: Momordicoside G
▶ Video
P53
♧ Ingredient: Bitter Gourd ⌬ Compound: Momordicoside G
▶ Video
Caspase-3
♧ Ingredient: Bitter Gourd ⌬ Compound: Momordicoside G
▶ Video
⌬
▸
✣
Apoptosis
Caspase Signaling
▸
ROS
♧ Ingredient: Black Pepper ⌬ Compound: Pinene
▶ Video
⌬
▸
✣
Apoptosis
RO-induced Apoptotic Signaling
▸
Caspase-3
♧ Ingredient: Long Pepper ⌬ Compound: Piperlongumine
▶ Video
⌬
▸
✣
Apoptosis
NF-κB Signaling
▸
Caspase-3
♧ Ingredient: Long Pepper ⌬ Compound: Piperlonguminine
▶ Video
Caspase-9
♧ Ingredient: Long Pepper ⌬ Compound: Piperlonguminine
▶ Video
BCL-2
♧ Ingredient: Long Pepper ⌬ Compound: Piperlonguminine
▶ Video
⌬
▸
✣
Inflammation
cAMP/Epac Signaling
▸
TNF-α
♧ Ingredient: Pricky brinjal Root ⌬ Compound: Quercetin
▶ Video
IL-6
♧ Ingredient: Pricky brinjal Root ⌬ Compound: Quercetin
▶ Video
IL-1β
♧ Ingredient: Pricky brinjal Root ⌬ Compound: Quercetin
▶ Video
✣
Mucus Hypersecretion
PKC/EGFR/ERK Signaling
▸
PKC
♧ Ingredient: Turmeric ⌬ Compound: Quercetin
▶ Video
Mucin
♧ Ingredient: Turmeric ⌬ Compound: Quercetin
▶ Video
✣
Fibrosis
TGF-β/AKT/mTOR Signaling
▸
IL-6
♧ Ingredient: Ginkgo biloba ⌬ Compound: Quercetin
▶ Video
IL-8
♧ Ingredient: Ginkgo biloba ⌬ Compound: Quercetin
▶ Video
COL-1
♧ Ingredient: Ginkgo biloba ⌬ Compound: Quercetin
▶ Video
COL-3
♧ Ingredient: Ginkgo biloba ⌬ Compound: Quercetin
▶ Video
VEGF
♧ Ingredient: Ginkgo biloba ⌬ Compound: Quercetin
▶ Video
⌬
▸
✣
Inflammation
MCP-1/RANTES Signaling
▸
IL-13
♧ Ingredient: Garlic ⌬ Compound: S-allylcysteine
▶ Video
MCP-1
♧ Ingredient: Garlic ⌬ Compound: S-allylcysteine
▶ Video
RANTES
♧ Ingredient: Garlic ⌬ Compound: S-allylcysteine
▶ Video
⌬
▸
✣
Fibrosis
Inflammatory Signaling
▸
IL-1β
♧ Ingredient: Red Sage ⌬ Compound: Salvianolic acid B
▶ Video
TNF-α
♧ Ingredient: Red Sage ⌬ Compound: Salvianolic acid B
▶ Video
⌬
▸
✣
Smooth Muscle Contraction
RhoA/ROCK Signaling
▸
MAPK
♧ Ingredient: Schisandra ⌬ Compound: Schisantherin A
▶ Video
✣
Mucus Hypersecretion
Mucin Signaling
▸
Mucin 5
♧ Ingredient: Schisandra ⌬ Compound: Schisantherin A
▶ Video
⌬
▸
✣
Cell Proliferation
STAT1 Signaling
▸
p-STAT1
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Solamargine
▶ Video
PD-L1
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Solamargine
▶ Video
and apoptosis index proteins
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Solamargine
▶ Video
✣
Chemoresistance
P-gp-Mediated Drug efflux Signaling
▸
P-gp
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Solamargine
▶ Video
⌬
▸
✣
Fibrosis
TGF-β/SMAD Signaling
▸
N-cadherin
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Solasodine
▶ Video
Fibronectin
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Solasodine
▶ Video
MMP-2
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Solasodine
▶ Video
✣
Airway Hyperresponsiveness
Ova-induced Th2 Signaling
▸
IL-4
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Solasodine
▶ Video
TNF-α
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Solasodine
▶ Video
IL-1β
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Solasodine
▶ Video
⌬
▸
✣
Epithelial-Mesenchymal Transition
TK-mediated Smad2 Signaling
▸
E-cadherin
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Solasonine
▶ Video
N-cadherin
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Solasonine
▶ Video
✣
Epithelial-Mesenchymal Transition
IL-6-induced STAT3/PD-L1 Signaling
▸
E-cadherin
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Solasonine
▶ Video
N-cadherin
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Solasonine
▶ Video
⌬
▸
✣
Inflammation
NF-κB/MAPK Signaling
▸
IL-1β
♧ Ingredient: Pricky brinjal Root ⌬ Compound: Tomatidine
▶ Video
IL-6
♧ Ingredient: Pricky brinjal Root ⌬ Compound: Tomatidine
▶ Video
TNF-α
♧ Ingredient: Pricky brinjal Root ⌬ Compound: Tomatidine
▶ Video
⌬
▸
✣
Inflammation
FcεRI/Lyn + Syk/MAPK Signaling
▸
IL-4
♧ Ingredient: Adathoda-Leaf ⌬ Compound: Vasicine
▶ Video
IL-5
♧ Ingredient: Adathoda-Leaf ⌬ Compound: Vasicine
▶ Video
IL-9
♧ Ingredient: Adathoda-Leaf ⌬ Compound: Vasicine
▶ Video
and IL-13
♧ Ingredient: Adathoda-Leaf ⌬ Compound: Vasicine
▶ Video
⌬
▸
✣
Apoptosis
Cytochrome C/Caspase-3 Signaling
▸
BCL-2
♧ Ingredient: Adathoda-Leaf ⌬ Compound: Vasicinone
▶ Video
PARP
♧ Ingredient: Adathoda-Leaf ⌬ Compound: Vasicinone
▶ Video
✣
Apoptosis
Fas Signaling
▸
FasL
♧ Ingredient: Adathoda-Leaf ⌬ Compound: Vasicinone
▶ Video
⌬
▸
✣
Inflammation
Th2 Signaling
▸
IL-4
♧ Ingredient: Adathoda-Leaf ⌬ Compound: Vasicolinone
▶ Video
⌬
▸
✣
Inflammation
MAPK Signaling
▸
IL-1
♧ Ingredient: Schisandra Fruit ⌬ Compound: Vitamin A
▶ Video
IL-8
♧ Ingredient: Schisandra Fruit ⌬ Compound: Vitamin A
▶ Video
⌬
▸
✣
Bronchoconstriction
NF-κB Signaling
▸
IgG
♧ Ingredient: Garlic ⌬ Compound: Vitamin E
▶ Video
⌬
▸
✣
Inflammation
NF-κB Signaling
▸
TNF-α
♧ Ingredient: Dried Ginger ⌬ Compound: Zingerone
▶ Video
✣
Oxidative Stress
AMPK/Nrf2/HO-1 Signaling
▸
ROS
♧ Ingredient: Dried Ginger ⌬ Compound: Zingerone
▶ Video
HO-1
♧ Ingredient: Dried Ginger ⌬ Compound: Zingerone
▶ Video
⌬
▸
✣
Inflammation
RIG-1 Signaling
▸
TNF-α
♧ Ingredient: Black Cumin ⌬ Compound: ß-sitosterol
▶ Video
IL-4
♧ Ingredient: Black Cumin ⌬ Compound: ß-sitosterol
▶ Video
IL-5
♧ Ingredient: Black Cumin ⌬ Compound: ß-sitosterol
▶ Video
IL-13
♧ Ingredient: Black Cumin ⌬ Compound: ß-sitosterol
▶ Video
IL-21
♧ Ingredient: Black Cumin ⌬ Compound: ß-sitosterol
▶ Video
✣
Fibrosis
TGF-β Signaling
▸
E-cadherin
♧ Ingredient: Black Cumin ⌬ Compound: ß-sitosterol
▶ Video
Vimentin
♧ Ingredient: Black Cumin ⌬ Compound: ß-sitosterol
▶ Video
α-SMA
♧ Ingredient: Black Cumin ⌬ Compound: ß-sitosterol
▶ Video
⌬
▸
✣
Apoptosis
PI3K/AKT Signalling
▸
Caspase-3
♧ Ingredient: Long Pepper ⌬ Compound: α-Bisabolol
▶ Video
PI3K
♧ Ingredient: Long Pepper ⌬ Compound: α-Bisabolol
▶ Video
AKT
♧ Ingredient: Long Pepper ⌬ Compound: α-Bisabolol
▶ Video
⌬
▸
✣
Apoptosis
Caspase9/3 Signaling
▸
BAX/Bcl‐2 ratio
♧ Ingredient: Black Pepper ⌬ Compound: α-Caryophyllene
▶ Video
Caspase-3
♧ Ingredient: Black Pepper ⌬ Compound: α-Caryophyllene
▶ Video
✣
Cell Proliferation
p21/cyclin D Signaling
▸
p21
♧ Ingredient: Black Pepper ⌬ Compound: α-Caryophyllene
▶ Video
cyclin E2
♧ Ingredient: Black Pepper ⌬ Compound: α-Caryophyllene
▶ Video
CDK4
♧ Ingredient: Black Pepper ⌬ Compound: α-Caryophyllene
▶ Video
CDK2
♧ Ingredient: Black Pepper ⌬ Compound: α-Caryophyllene
▶ Video
CDK6
♧ Ingredient: Black Pepper ⌬ Compound: α-Caryophyllene
▶ Video
and cyclin D3
♧ Ingredient: Black Pepper ⌬ Compound: α-Caryophyllene
▶ Video
⌬
▸
✣
Inflammation
ACE2/MasR Signaling
▸
TNF-α
♧ Ingredient: Black Pepper ⌬ Compound: β-Caryophyllene
▶ Video
IL-1β
♧ Ingredient: Black Pepper ⌬ Compound: β-Caryophyllene
▶ Video
IL-6
♧ Ingredient: Black Pepper ⌬ Compound: β-Caryophyllene
▶ Video
✣
Apoptosis
PI3K/AKT/mTOR Signaling
▸
Caspase-3
♧ Ingredient: Long Pepper ⌬ Compound: β-Caryophyllene
▶ Video
Caspase-9
♧ Ingredient: Long Pepper ⌬ Compound: β-Caryophyllene
▶ Video
BCL-2
♧ Ingredient: Long Pepper ⌬ Compound: β-Caryophyllene
▶ Video
✣
Metastasis
VEGF/VEGFR2 Signaling
▸
VEGF
♧ Ingredient: Long Pepper ⌬ Compound: β-Caryophyllene
▶ Video
✣
Oxidative Stress
Nrf2 Signaling
▸
MPO
♧ Ingredient: Black Pepper ⌬ Compound: β-Caryophyllene
▶ Video
GPx
♧ Ingredient: Black Pepper ⌬ Compound: β-Caryophyllene
▶ Video
MDA
♧ Ingredient: Black Pepper ⌬ Compound: β-Caryophyllene
▶ Video
ROS
♧ Ingredient: Black Pepper ⌬ Compound: β-Caryophyllene
▶ Video
⌬
▸
✣
Apoptosis
PI3K/AKT/mTOR/CD1 Signaling
▸
PARP1
♧ Ingredient: Adathoda-Leaf ⌬ Compound: β-Sitosterol
▶ Video
cleaved caspase-3
♧ Ingredient: Adathoda-Leaf ⌬ Compound: β-Sitosterol
▶ Video
BCL-2
♧ Ingredient: Adathoda-Leaf ⌬ Compound: β-Sitosterol
▶ Video
and BAX
♧ Ingredient: Adathoda-Leaf ⌬ Compound: β-Sitosterol
▶ Video

Ingredients affecting Asthma

Explore therapeutic ingredients and their constituent compounds that modulate asthma biology.

♧
Adathoda-Leaf
4 active compound(s)
▸
⌬
Vasicine
Inflammation → FcεRI/Lyn + Syk/MAPK Signaling
▸
IL-4
♧ Ingredient: Adathoda-Leaf ⌬ Compound: Vasicine
▶ Video
IL-5
♧ Ingredient: Adathoda-Leaf ⌬ Compound: Vasicine
▶ Video
IL-9
♧ Ingredient: Adathoda-Leaf ⌬ Compound: Vasicine
▶ Video
and IL-13
♧ Ingredient: Adathoda-Leaf ⌬ Compound: Vasicine
▶ Video
⌬
Vasicolinone
Inflammation → Th2 Signaling
▸
IL-4
♧ Ingredient: Adathoda-Leaf ⌬ Compound: Vasicolinone
▶ Video
⌬
Vasicinone
Apoptosis → Cytochrome C/Caspase-3 Signaling
▸
BCL-2
♧ Ingredient: Adathoda-Leaf ⌬ Compound: Vasicinone
▶ Video
PARP
♧ Ingredient: Adathoda-Leaf ⌬ Compound: Vasicinone
▶ Video
⌬
β-Sitosterol
Apoptosis → PI3K/AKT/mTOR/CD1 Signaling
▸
PARP1
♧ Ingredient: Adathoda-Leaf ⌬ Compound: β-Sitosterol
▶ Video
cleaved caspase-3
♧ Ingredient: Adathoda-Leaf ⌬ Compound: β-Sitosterol
▶ Video
BCL-2
♧ Ingredient: Adathoda-Leaf ⌬ Compound: β-Sitosterol
▶ Video
and BAX
♧ Ingredient: Adathoda-Leaf ⌬ Compound: β-Sitosterol
▶ Video
♧
Astragalus
3 active compound(s)
▸
⌬
Calycosin
Inflammation → NRF2/Keap Signaling
▸
SOD
♧ Ingredient: Astragalus ⌬ Compound: Calycosin
▶ Video
CAT
♧ Ingredient: Astragalus ⌬ Compound: Calycosin
▶ Video
⌬
Astragaloside IV
Mucus Hypersecretion → CHOP/MUC5AC Signaling
▸
Mucin 5
♧ Ingredient: Astragalus ⌬ Compound: Astragaloside IV
▶ Video
CHOP
♧ Ingredient: Astragalus ⌬ Compound: Astragaloside IV
▶ Video
⌬
Baicalein
Mucus Hypersecretion → IL-13 Signaling
▸
IL-13
♧ Ingredient: Astragalus ⌬ Compound: Baicalein
▶ Video
Mucin-5
♧ Ingredient: Astragalus ⌬ Compound: Baicalein
▶ Video
♧
Bitter Gourd
1 active compound(s)
▸
⌬
Momordicoside G
Inflammation → NF-κB/ICAM-1 Signaling
▸
NF-κB
♧ Ingredient: Bitter Gourd ⌬ Compound: Momordicoside G
▶ Video
ICAM-1
♧ Ingredient: Bitter Gourd ⌬ Compound: Momordicoside G
▶ Video
♧
Black Cumin
2 active compound(s)
▸
⌬
Limonene
Inflammation → cAMP/PKA Signaling
▸
IgG
♧ Ingredient: Black Cumin ⌬ Compound: Limonene
▶ Video
IgE
♧ Ingredient: Black Cumin ⌬ Compound: Limonene
▶ Video
IL-5
♧ Ingredient: Black Cumin ⌬ Compound: Limonene
▶ Video
⌬
ß-sitosterol
Inflammation → RIG-1 Signaling
▸
TNF-α
♧ Ingredient: Black Cumin ⌬ Compound: ß-sitosterol
▶ Video
IL-4
♧ Ingredient: Black Cumin ⌬ Compound: ß-sitosterol
▶ Video
IL-5
♧ Ingredient: Black Cumin ⌬ Compound: ß-sitosterol
▶ Video
IL-13
♧ Ingredient: Black Cumin ⌬ Compound: ß-sitosterol
▶ Video
IL-21
♧ Ingredient: Black Cumin ⌬ Compound: ß-sitosterol
▶ Video
♧
Black Pepper
4 active compound(s)
▸
⌬
β-Caryophyllene
Inflammation → ACE2/MasR Signaling
▸
TNF-α
♧ Ingredient: Black Pepper ⌬ Compound: β-Caryophyllene
▶ Video
IL-1β
♧ Ingredient: Black Pepper ⌬ Compound: β-Caryophyllene
▶ Video
IL-6
♧ Ingredient: Black Pepper ⌬ Compound: β-Caryophyllene
▶ Video
⌬
α-Caryophyllene
Apoptosis → Caspase9/3 Signaling
▸
BAX/Bcl‐2 ratio
♧ Ingredient: Black Pepper ⌬ Compound: α-Caryophyllene
▶ Video
Caspase-3
♧ Ingredient: Black Pepper ⌬ Compound: α-Caryophyllene
▶ Video
⌬
Pinene
Apoptosis → Caspase Signaling
▸
ROS
♧ Ingredient: Black Pepper ⌬ Compound: Pinene
▶ Video
⌬
Limonene
Neutrophil Infiltration → ß2-integrin mediated Signaling
▸
TNF-α
♧ Ingredient: Black Pepper ⌬ Compound: Limonene
▶ Video
IL-1β
♧ Ingredient: Black Pepper ⌬ Compound: Limonene
▶ Video
IL-6
♧ Ingredient: Black Pepper ⌬ Compound: Limonene
▶ Video
♧
Chinese Skullcap
0 active compound(s)
▸
♧
Chinese Skullcap Root
2 active compound(s)
▸
⌬
Baicalein
Inflammation → Arachidonic Acid Signaling
▸
PGE2
♧ Ingredient: Chinese Skullcap Root ⌬ Compound: Baicalein
⌬
Baicalin
Smooth Muscle Contraction → Ca2+ Signaling
▸
MLCP
♧ Ingredient: Chinese Skullcap Root ⌬ Compound: Baicalin
♧
Dong Quai
1 active compound(s)
▸
⌬
Ligustilide
Inflammation → TNF-α Signalling
▸
TNF-α
♧ Ingredient: Dong Quai ⌬ Compound: Ligustilide
▶ Video
♧
Dong Quai Root
1 active compound(s)
▸
⌬
Ligustilide
Mucus Hypersecretion → EGFR Signaling
▸
Mucin 5
♧ Ingredient: Dong Quai Root ⌬ Compound: Ligustilide
♧
Dried Ginger
5 active compound(s)
▸
⌬
Zingerone
Inflammation → NF-κB Signaling
▸
TNF-α
♧ Ingredient: Dried Ginger ⌬ Compound: Zingerone
▶ Video
⌬
10-Shogaol
Inflammation → NLRP3 Signaling
▸
IL-1β
♧ Ingredient: Dried Ginger ⌬ Compound: 10-Shogaol
▶ Video
Caspase-1
♧ Ingredient: Dried Ginger ⌬ Compound: 10-Shogaol
▶ Video
NLRP3
♧ Ingredient: Dried Ginger ⌬ Compound: 10-Shogaol
▶ Video
⌬
Gingerenone-A
Inflammation → TLR4/MyD88/NF-κB Signaling
▸
Collagen
♧ Ingredient: Dried Ginger ⌬ Compound: Gingerenone-A
▶ Video
E-cadherin
♧ Ingredient: Dried Ginger ⌬ Compound: Gingerenone-A
▶ Video
ß-catenin
♧ Ingredient: Dried Ginger ⌬ Compound: Gingerenone-A
▶ Video
⌬
6-Shogaol
Apoptosis → EGFR Signaling
▸
p-AKT
♧ Ingredient: Dried Ginger ⌬ Compound: 6-Shogaol
▶ Video
Cleaved Caspase-3
♧ Ingredient: Dried Ginger ⌬ Compound: 6-Shogaol
▶ Video
⌬
6-Gingerol
Fibrosis → TGF-β1 Signaling
▸
α-SMA
♧ Ingredient: Dried Ginger ⌬ Compound: 6-Gingerol
▶ Video
Collagen IV
♧ Ingredient: Dried Ginger ⌬ Compound: 6-Gingerol
▶ Video
♧
Eucalyptus
1 active compound(s)
▸
⌬
1,8‑Cineole
Inflammation → SOD/H2O2 Signaling
▸
SOD
♧ Ingredient: Eucalyptus ⌬ Compound: 1,8‑Cineole
H2O2
♧ Ingredient: Eucalyptus ⌬ Compound: 1,8‑Cineole
O₂⁻
♧ Ingredient: Eucalyptus ⌬ Compound: 1,8‑Cineole
♧
Gardenia Fruit
0 active compound(s)
▸
♧
Garlic
3 active compound(s)
▸
⌬
S-allylcysteine
Inflammation → MCP-1/RANTES Signaling
▸
IL-13
♧ Ingredient: Garlic ⌬ Compound: S-allylcysteine
▶ Video
MCP-1
♧ Ingredient: Garlic ⌬ Compound: S-allylcysteine
▶ Video
RANTES
♧ Ingredient: Garlic ⌬ Compound: S-allylcysteine
▶ Video
⌬
Kaempferol
Inflammation → JAK2/NF-κB Signaling
▸
TNF-α
♧ Ingredient: Garlic ⌬ Compound: Kaempferol
▶ Video
⌬
Vitamin E
Bronchoconstriction → NF-κB Signaling
▸
IgG
♧ Ingredient: Garlic ⌬ Compound: Vitamin E
▶ Video
♧
Ginger
1 active compound(s)
▸
⌬
6-Gingerol
Bronchodilation → PDE4/PKC/Ca2+ Signaling
▸
Ca2+ level
♧ Ingredient: Ginger ⌬ Compound: 6-Gingerol
▶ Video
♧
Ginkgo biloba
2 active compound(s)
▸
⌬
Ginkgolide B
Inflammation → ERK/MAPK Signaling
▸
ERK
♧ Ingredient: Ginkgo biloba ⌬ Compound: Ginkgolide B
▶ Video
TNF-α. IL-6
♧ Ingredient: Ginkgo biloba ⌬ Compound: Ginkgolide B
▶ Video
⌬
Quercetin
Fibrosis → TGF-β/AKT/mTOR Signaling
▸
IL-6
♧ Ingredient: Ginkgo biloba ⌬ Compound: Quercetin
▶ Video
IL-8
♧ Ingredient: Ginkgo biloba ⌬ Compound: Quercetin
▶ Video
COL-1
♧ Ingredient: Ginkgo biloba ⌬ Compound: Quercetin
▶ Video
COL-3
♧ Ingredient: Ginkgo biloba ⌬ Compound: Quercetin
▶ Video
VEGF
♧ Ingredient: Ginkgo biloba ⌬ Compound: Quercetin
▶ Video
♧
Licorice
7 active compound(s)
▸
⌬
Licochalcone B
Inflammation → LPS/TLR4 Signaling
▸
TNF-α and IL-1β
♧ Ingredient: Licorice ⌬ Compound: Licochalcone B
▶ Video
⌬
18β-Glycyrrhetinic Acid
Inflammation → IL-17 Signaling
▸
IL-17
♧ Ingredient: Licorice ⌬ Compound: 18β-Glycyrrhetinic Acid
▶ Video
RORYT
♧ Ingredient: Licorice ⌬ Compound: 18β-Glycyrrhetinic Acid
▶ Video
⌬
Glycyrrhizin
Inflammation → HMGB-1/TLR4 Signalling
▸
TNF‐α
♧ Ingredient: Licorice ⌬ Compound: Glycyrrhizin
▶ Video
IL‐1β and IL‐6
♧ Ingredient: Licorice ⌬ Compound: Glycyrrhizin
▶ Video
⌬
Liquiritigenin
Inflammation → cAMP Signaling
▸
cAMP Level
♧ Ingredient: Licorice ⌬ Compound: Liquiritigenin
▶ Video
⌬
Liquiritin
Inflammation → LPS Signaling
▸
TNF-α
♧ Ingredient: Licorice ⌬ Compound: Liquiritin
▶ Video
IL-1β
♧ Ingredient: Licorice ⌬ Compound: Liquiritin
▶ Video
and IL-6
♧ Ingredient: Licorice ⌬ Compound: Liquiritin
▶ Video
⌬
Isoliquiritigenin
Epithelial-Mesenchymal Transition → TGF-β Signaling
▸
Collagen & α-SMA
♧ Ingredient: Licorice ⌬ Compound: Isoliquiritigenin
▶ Video
⌬
Glabridin
Platelet Aggregation → PI3K/AKT/GSK3ß Signaling
▸
P-selectin
♧ Ingredient: Licorice ⌬ Compound: Glabridin
▶ Video
♧
Long Pepper
4 active compound(s)
▸
⌬
Piperlongumine
Apoptosis → RO-induced Apoptotic Signaling
▸
Caspase-3
♧ Ingredient: Long Pepper ⌬ Compound: Piperlongumine
▶ Video
⌬
Piperlonguminine
Apoptosis → NF-κB Signaling
▸
Caspase-3
♧ Ingredient: Long Pepper ⌬ Compound: Piperlonguminine
▶ Video
Caspase-9
♧ Ingredient: Long Pepper ⌬ Compound: Piperlonguminine
▶ Video
BCL-2
♧ Ingredient: Long Pepper ⌬ Compound: Piperlonguminine
▶ Video
⌬
α-Bisabolol
Apoptosis → PI3K/AKT Signalling
▸
Caspase-3
♧ Ingredient: Long Pepper ⌬ Compound: α-Bisabolol
▶ Video
PI3K
♧ Ingredient: Long Pepper ⌬ Compound: α-Bisabolol
▶ Video
AKT
♧ Ingredient: Long Pepper ⌬ Compound: α-Bisabolol
▶ Video
⌬
β-Caryophyllene
Apoptosis → PI3K/AKT/mTOR Signaling
▸
Caspase-3
♧ Ingredient: Long Pepper ⌬ Compound: β-Caryophyllene
▶ Video
Caspase-9
♧ Ingredient: Long Pepper ⌬ Compound: β-Caryophyllene
▶ Video
BCL-2
♧ Ingredient: Long Pepper ⌬ Compound: β-Caryophyllene
▶ Video
♧
Oregano
1 active compound(s)
▸
⌬
Carvacrol
Apoptosis → Caspase-3 Signaling
▸
BAX
♧ Ingredient: Oregano ⌬ Compound: Carvacrol
▶ Video
BCL-2
♧ Ingredient: Oregano ⌬ Compound: Carvacrol
▶ Video
Caspase-3
♧ Ingredient: Oregano ⌬ Compound: Carvacrol
▶ Video
♧
Pricky brinjal Root
4 active compound(s)
▸
⌬
Dioscin
Inflammation → TLR4/MyD88 Signaling
▸
IL‑1ß
♧ Ingredient: Pricky brinjal Root ⌬ Compound: Dioscin
▶ Video
IL‑6
♧ Ingredient: Pricky brinjal Root ⌬ Compound: Dioscin
▶ Video
TNF‑α
♧ Ingredient: Pricky brinjal Root ⌬ Compound: Dioscin
▶ Video
⌬
Tomatidine
Inflammation → NF-κB/MAPK Signaling
▸
IL-1β
♧ Ingredient: Pricky brinjal Root ⌬ Compound: Tomatidine
▶ Video
IL-6
♧ Ingredient: Pricky brinjal Root ⌬ Compound: Tomatidine
▶ Video
TNF-α
♧ Ingredient: Pricky brinjal Root ⌬ Compound: Tomatidine
▶ Video
⌬
Quercetin
Inflammation → cAMP/Epac Signaling
▸
TNF-α
♧ Ingredient: Pricky brinjal Root ⌬ Compound: Quercetin
▶ Video
IL-6
♧ Ingredient: Pricky brinjal Root ⌬ Compound: Quercetin
▶ Video
IL-1β
♧ Ingredient: Pricky brinjal Root ⌬ Compound: Quercetin
▶ Video
⌬
Apigenin
Angiogenesis → HIF-1α Signaling
▸
VEGF
♧ Ingredient: Pricky brinjal Root ⌬ Compound: Apigenin
▶ Video
♧
Red Pea Egg Plant - Root
5 active compound(s)
▸
⌬
Campesterol
Inflammation → NF-κB/JAK 2 Signaling
▸
IL-4
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Campesterol
▶ Video
IL-5
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Campesterol
▶ Video
AQP-1
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Campesterol
▶ Video
AQP-5
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Campesterol
▶ Video
⌬
Chlorogenic acid
Inflammation → PI3K/AKT Signaling
▸
IL-6
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Chlorogenic acid
▶ Video
IL-1β
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Chlorogenic acid
▶ Video
TNFα
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Chlorogenic acid
▶ Video
IL-10
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Chlorogenic acid
▶ Video
⌬
Solasonine
Epithelial-Mesenchymal Transition → TK-mediated Smad2 Signaling
▸
E-cadherin
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Solasonine
▶ Video
N-cadherin
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Solasonine
▶ Video
⌬
Solasodine
Fibrosis → TGF-β/SMAD Signaling
▸
N-cadherin
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Solasodine
▶ Video
Fibronectin
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Solasodine
▶ Video
MMP-2
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Solasodine
▶ Video
⌬
Solamargine
Cell Proliferation → STAT1 Signaling
▸
p-STAT1
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Solamargine
▶ Video
PD-L1
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Solamargine
▶ Video
and apoptosis index proteins
♧ Ingredient: Red Pea Egg Plant - Root ⌬ Compound: Solamargine
▶ Video
♧
Red Sage
1 active compound(s)
▸
⌬
Salvianolic acid B
Fibrosis → Inflammatory Signaling
▸
IL-1β
♧ Ingredient: Red Sage ⌬ Compound: Salvianolic acid B
▶ Video
TNF-α
♧ Ingredient: Red Sage ⌬ Compound: Salvianolic acid B
▶ Video
♧
Schisandra
1 active compound(s)
▸
⌬
Schisantherin A
Smooth Muscle Contraction → RhoA/ROCK Signaling
▸
MAPK
♧ Ingredient: Schisandra ⌬ Compound: Schisantherin A
▶ Video
♧
Schisandra Fruit
1 active compound(s)
▸
⌬
Vitamin A
Inflammation → MAPK Signaling
▸
IL-1
♧ Ingredient: Schisandra Fruit ⌬ Compound: Vitamin A
▶ Video
IL-8
♧ Ingredient: Schisandra Fruit ⌬ Compound: Vitamin A
▶ Video
♧
Turmeric
2 active compound(s)
▸
⌬
Curcumin
Inflammation → TNF-α/NF-κB Signaling
▸
IL-6
♧ Ingredient: Turmeric ⌬ Compound: Curcumin
▶ Video
IL-2
♧ Ingredient: Turmeric ⌬ Compound: Curcumin
▶ Video
IL-5
♧ Ingredient: Turmeric ⌬ Compound: Curcumin
▶ Video
GM-CSF
♧ Ingredient: Turmeric ⌬ Compound: Curcumin
▶ Video
⌬
Quercetin
Mucus Hypersecretion → PKC/EGFR/ERK Signaling
▸
PKC
♧ Ingredient: Turmeric ⌬ Compound: Quercetin
▶ Video
Mucin
♧ Ingredient: Turmeric ⌬ Compound: Quercetin
▶ Video
♧
White Mulberry Root - Bark
0 active compound(s)
▸