skin-diseases

Skin Diseases - Gods
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Skin Diseases

Disease / Phenomenon

Disorders of the skin barrier and its immune environment, ranging from inflammatory flare-ups to impaired repair and pigmentation changes.

Biological Processes of Skin Diseases

Explore the key biological processes that drive skin diseases, from cellular mechanisms through tissue-level responses.

✣
Angiogenesis
1 pathway(s)
▸
▣
VEGF Signaling
Target: VEGF
▸
VEGF
♧ Ingredient: Neem ⌬ Compound: Azadirachtin A
▶ Video
✣
Melanogenesis
2 pathway(s)
▸
▣
α-MSH/MC1R Signaling
Target: Tyrosinase
▸
MITF
♧ Ingredient: Neem ⌬ Compound: Gedunin
▶ Video
Tyrosinase
♧ Ingredient: Neem ⌬ Compound: Gedunin
▶ Video
▣
ERK/MITF Signaling
Target: ERK
▸
Microphthalmia‐associated transcription factor (MITF)
♧ Ingredient: Turmeric ⌬ Compound: Curcumin
▶ Video
tyrosine
♧ Ingredient: Turmeric ⌬ Compound: Curcumin
▶ Video
tyrosinase‐related protein 1 and 2 (TRP-1 and TRP-2) expression
♧ Ingredient: Turmeric ⌬ Compound: Curcumin
▶ Video
✣
Tissue Remodelling
4 pathway(s)
▸
▣
ROS/AP-1 Signaling
Target: ROS
▸
ROS
♧ Ingredient: Neem ⌬ Compound: Rutin
▶ Video
MMP-1
♧ Ingredient: Neem ⌬ Compound: Rutin
▶ Video
▣
TGF-β Signaling
Target: TGF-β
▸
Collagen
♧ Ingredient: Lavender ⌬ Compound: Linalool
▶ Video
Elastin
♧ Ingredient: Lavender ⌬ Compound: Linalool
▶ Video
▣
MAPK Signaling
Target: ROS
▸
ROS
♧ Ingredient: Thyme ⌬ Compound: Thymol
▶ Video
MMP-1
♧ Ingredient: Thyme ⌬ Compound: Thymol
▶ Video
▣
Nrf2/ARE Signaling
Target: Nrf2
▸
SOD1
♧ Ingredient: Centella asiatica ⌬ Compound: Madecassoside
▶ Video
GPX
♧ Ingredient: Centella asiatica ⌬ Compound: Madecassoside
▶ Video
CAT
♧ Ingredient: Centella asiatica ⌬ Compound: Madecassoside
▶ Video
MMP-9
♧ Ingredient: Centella asiatica ⌬ Compound: Madecassoside
▶ Video
✣
Inflammation
11 pathway(s)
▸
▣
IL-6/JAK/STAT Signaling
Target: IL-6
▸
TNF-α & IL-17A
♧ Ingredient: Lavender ⌬ Compound: Linalyl acetate
▶ Video
▣
IL-17A Signaling
Target: PI3K
▸
IL-6
♧ Ingredient: Lavender ⌬ Compound: Camphor
▶ Video
CCL20
♧ Ingredient: Lavender ⌬ Compound: Camphor
▶ Video
and CCL2
♧ Ingredient: Lavender ⌬ Compound: Camphor
▶ Video
▣
Propionibacterium acnes/TLR-2 Signaling
Target: NF-κB
▸
IL-1β
♧ Ingredient: Centella asiatica ⌬ Compound: Madecassoside
▶ Video
▣
TNFR/NF-κB Signaling
Target: NF-κB
▸
TNF-α
♧ Ingredient: Turmeric ⌬ Compound: Curcumin
▶ Video
IL-6
♧ Ingredient: Turmeric ⌬ Compound: Curcumin
▶ Video
IL-8
♧ Ingredient: Turmeric ⌬ Compound: Curcumin
▶ Video
▣
PLCγ Signaling
Target: PLCγ
▸
Histamine
♧ Ingredient: Eucalyptus ⌬ Compound: 1,8‑Cineole
▣
p38 Signaling
Target: p38
▸
IL-4 & IL-13
♧ Ingredient: Eucalyptus ⌬ Compound: 1,8‑Cineole
▣
LPS/TLR4 Signaling
Target: NF-κB
▸
TNFα
♧ Ingredient: Eucalyptus ⌬ Compound: 1,8‑Cineole
IL-8
♧ Ingredient: Eucalyptus ⌬ Compound: 1,8‑Cineole
▣
TPA-induced COX-2 Signaling
Target: NF-κB
▸
COX-2
♧ Ingredient: Black Cumin ⌬ Compound: Thymoquinone
▣
NLRP3 Signaling
Target: NLRP3
▸
IL-1β
♧ Ingredient: Black Cumin ⌬ Compound: Thymoquinone
IL-18
♧ Ingredient: Black Cumin ⌬ Compound: Thymoquinone
▣
TH1/TH2/TH17 Signaling
Target: Staphylococcus aureus membrane vesicles (MVs)
▸
IFN-γ
♧ Ingredient: Black Cumin ⌬ Compound: Thymol
IL-13
♧ Ingredient: Black Cumin ⌬ Compound: Thymol
IL-31 and IL-17A
♧ Ingredient: Black Cumin ⌬ Compound: Thymol
▣
Dinitrofluorobenzene-induced Inflammatory Signaling
Target: TSLP
▸
TSLP
♧ Ingredient: Black Cumin ⌬ Compound: β-Sitosterol
IL-4
♧ Ingredient: Black Cumin ⌬ Compound: β-Sitosterol
IL-6
♧ Ingredient: Black Cumin ⌬ Compound: β-Sitosterol
✣
Itching
1 pathway(s)
▸
▣
Ca2+/TRPM8 Signaling
Target: TRPM8
▸
Ca2+ level
♧ Ingredient: Thyme ⌬ Compound: Thymol
▶ Video
✣
Skin Hydration
1 pathway(s)
▸
▣
HA Signaling
Target: Hyaluronic acid synthase (HAS)
▸
HA
♧ Ingredient: Centella asiatica ⌬ Compound: Madecassoside
▶ Video
ROS
♧ Ingredient: Centella asiatica ⌬ Compound: Madecassoside
▶ Video
✣
Skin Barrier Integrity
1 pathway(s)
▸
▣
Cornified Envelope Synthesis Pathway
Target: Keratin 16
▸
Ceramide-Lipid Conjugate
♧ Ingredient: Dulse Flakes Kelp ⌬ Compound: β-Carotene
✣
Oxidative Stress
1 pathway(s)
▸
▣
Oxidative Stress Pathway
Target: Superoxide
▸
Superoxide
♧ Ingredient: Dulse Flakes Kelp ⌬ Compound: β-Carotene

Compounds affecting Skin Diseases

Browse active compounds and their direct impact on skin diseases biological processes, pathways, and biomarkers.

⌬
▸
✣
Inflammation
PLCγ Signaling
▸
Histamine
♧ Ingredient: Eucalyptus ⌬ Compound: 1,8‑Cineole
✣
Inflammation
p38 Signaling
▸
IL-4 & IL-13
♧ Ingredient: Eucalyptus ⌬ Compound: 1,8‑Cineole
✣
Inflammation
LPS/TLR4 Signaling
▸
TNFα
♧ Ingredient: Eucalyptus ⌬ Compound: 1,8‑Cineole
IL-8
♧ Ingredient: Eucalyptus ⌬ Compound: 1,8‑Cineole
⌬
▸
✣
Angiogenesis
VEGF Signaling
▸
VEGF
♧ Ingredient: Neem ⌬ Compound: Azadirachtin A
▶ Video
⌬
▸
✣
Inflammation
IL-17A Signaling
▸
IL-6
♧ Ingredient: Lavender ⌬ Compound: Camphor
▶ Video
CCL20
♧ Ingredient: Lavender ⌬ Compound: Camphor
▶ Video
and CCL2
♧ Ingredient: Lavender ⌬ Compound: Camphor
▶ Video
⌬
▸
✣
Melanogenesis
ERK/MITF Signaling
▸
Microphthalmia‐associated transcription factor (MITF)
♧ Ingredient: Turmeric ⌬ Compound: Curcumin
▶ Video
tyrosine
♧ Ingredient: Turmeric ⌬ Compound: Curcumin
▶ Video
tyrosinase‐related protein 1 and 2 (TRP-1 and TRP-2) expression
♧ Ingredient: Turmeric ⌬ Compound: Curcumin
▶ Video
✣
Inflammation
TNFR/NF-κB Signaling
▸
TNF-α
♧ Ingredient: Turmeric ⌬ Compound: Curcumin
▶ Video
IL-6
♧ Ingredient: Turmeric ⌬ Compound: Curcumin
▶ Video
IL-8
♧ Ingredient: Turmeric ⌬ Compound: Curcumin
▶ Video
⌬
Gedunin
From Neem
▸
✣
Melanogenesis
α-MSH/MC1R Signaling
▸
MITF
♧ Ingredient: Neem ⌬ Compound: Gedunin
▶ Video
Tyrosinase
♧ Ingredient: Neem ⌬ Compound: Gedunin
▶ Video
⌬
▸
✣
Tissue Remodelling
TGF-β Signaling
▸
Collagen
♧ Ingredient: Lavender ⌬ Compound: Linalool
▶ Video
Elastin
♧ Ingredient: Lavender ⌬ Compound: Linalool
▶ Video
⌬
▸
✣
Inflammation
IL-6/JAK/STAT Signaling
▸
TNF-α & IL-17A
♧ Ingredient: Lavender ⌬ Compound: Linalyl acetate
▶ Video
⌬
▸
✣
Tissue Remodelling
Nrf2/ARE Signaling
▸
SOD1
♧ Ingredient: Centella asiatica ⌬ Compound: Madecassoside
▶ Video
GPX
♧ Ingredient: Centella asiatica ⌬ Compound: Madecassoside
▶ Video
CAT
♧ Ingredient: Centella asiatica ⌬ Compound: Madecassoside
▶ Video
MMP-9
♧ Ingredient: Centella asiatica ⌬ Compound: Madecassoside
▶ Video
✣
Inflammation
Propionibacterium acnes/TLR-2 Signaling
▸
IL-1β
♧ Ingredient: Centella asiatica ⌬ Compound: Madecassoside
▶ Video
✣
Skin Hydration
HA Signaling
▸
HA
♧ Ingredient: Centella asiatica ⌬ Compound: Madecassoside
▶ Video
ROS
♧ Ingredient: Centella asiatica ⌬ Compound: Madecassoside
▶ Video
⌬
Rutin
From Neem
▸
✣
Tissue Remodelling
ROS/AP-1 Signaling
▸
ROS
♧ Ingredient: Neem ⌬ Compound: Rutin
▶ Video
MMP-1
♧ Ingredient: Neem ⌬ Compound: Rutin
▶ Video
⌬
Thymol
From Thyme
▸
✣
Tissue Remodelling
MAPK Signaling
▸
ROS
♧ Ingredient: Thyme ⌬ Compound: Thymol
▶ Video
MMP-1
♧ Ingredient: Thyme ⌬ Compound: Thymol
▶ Video
✣
Inflammation
TH1/TH2/TH17 Signaling
▸
IFN-γ
♧ Ingredient: Black Cumin ⌬ Compound: Thymol
IL-13
♧ Ingredient: Black Cumin ⌬ Compound: Thymol
IL-31 and IL-17A
♧ Ingredient: Black Cumin ⌬ Compound: Thymol
✣
Itching
Ca2+/TRPM8 Signaling
▸
Ca2+ level
♧ Ingredient: Thyme ⌬ Compound: Thymol
▶ Video
⌬
▸
✣
Inflammation
TPA-induced COX-2 Signaling
▸
COX-2
♧ Ingredient: Black Cumin ⌬ Compound: Thymoquinone
✣
Inflammation
NLRP3 Signaling
▸
IL-1β
♧ Ingredient: Black Cumin ⌬ Compound: Thymoquinone
IL-18
♧ Ingredient: Black Cumin ⌬ Compound: Thymoquinone
⌬
▸
✣
Skin Barrier Integrity
Cornified Envelope Synthesis Pathway
▸
Ceramide-Lipid Conjugate
♧ Ingredient: Dulse Flakes Kelp ⌬ Compound: β-Carotene
✣
Oxidative Stress
Oxidative Stress Pathway
▸
Superoxide
♧ Ingredient: Dulse Flakes Kelp ⌬ Compound: β-Carotene
⌬
▸
✣
Inflammation
Dinitrofluorobenzene-induced Inflammatory Signaling
▸
TSLP
♧ Ingredient: Black Cumin ⌬ Compound: β-Sitosterol
IL-4
♧ Ingredient: Black Cumin ⌬ Compound: β-Sitosterol
IL-6
♧ Ingredient: Black Cumin ⌬ Compound: β-Sitosterol

Ingredients affecting Skin Diseases

Explore therapeutic ingredients and their constituent compounds that modulate skin diseases biology.

♧
Black Cumin
3 active compound(s)
▸
⌬
Thymoquinone
Inflammation → TPA-induced COX-2 Signaling
▸
COX-2
♧ Ingredient: Black Cumin ⌬ Compound: Thymoquinone
⌬
Thymol
Inflammation → TH1/TH2/TH17 Signaling
▸
IFN-γ
♧ Ingredient: Black Cumin ⌬ Compound: Thymol
IL-13
♧ Ingredient: Black Cumin ⌬ Compound: Thymol
IL-31 and IL-17A
♧ Ingredient: Black Cumin ⌬ Compound: Thymol
⌬
β-Sitosterol
Inflammation → Dinitrofluorobenzene-induced Inflammatory Signaling
▸
TSLP
♧ Ingredient: Black Cumin ⌬ Compound: β-Sitosterol
IL-4
♧ Ingredient: Black Cumin ⌬ Compound: β-Sitosterol
IL-6
♧ Ingredient: Black Cumin ⌬ Compound: β-Sitosterol
♧
Bladderwrack Kelp
0 active compound(s)
▸
♧
Centella asiatica
1 active compound(s)
▸
⌬
Madecassoside
Tissue Remodelling → Nrf2/ARE Signaling
▸
SOD1
♧ Ingredient: Centella asiatica ⌬ Compound: Madecassoside
▶ Video
GPX
♧ Ingredient: Centella asiatica ⌬ Compound: Madecassoside
▶ Video
CAT
♧ Ingredient: Centella asiatica ⌬ Compound: Madecassoside
▶ Video
MMP-9
♧ Ingredient: Centella asiatica ⌬ Compound: Madecassoside
▶ Video
♧
Dulse Flakes Kelp
1 active compound(s)
▸
⌬
β-Carotene
Skin Barrier Integrity → Cornified Envelope Synthesis Pathway
▸
Ceramide-Lipid Conjugate
♧ Ingredient: Dulse Flakes Kelp ⌬ Compound: β-Carotene
♧
Eucalyptus
1 active compound(s)
▸
⌬
1,8‑Cineole
Inflammation → PLCγ Signaling
▸
Histamine
♧ Ingredient: Eucalyptus ⌬ Compound: 1,8‑Cineole
♧
Flaxseed
0 active compound(s)
▸
♧
Lavender
3 active compound(s)
▸
⌬
Linalool
Tissue Remodelling → TGF-β Signaling
▸
Collagen
♧ Ingredient: Lavender ⌬ Compound: Linalool
▶ Video
Elastin
♧ Ingredient: Lavender ⌬ Compound: Linalool
▶ Video
⌬
Linalyl acetate
Inflammation → IL-6/JAK/STAT Signaling
▸
TNF-α & IL-17A
♧ Ingredient: Lavender ⌬ Compound: Linalyl acetate
▶ Video
⌬
Camphor
Inflammation → IL-17A Signaling
▸
IL-6
♧ Ingredient: Lavender ⌬ Compound: Camphor
▶ Video
CCL20
♧ Ingredient: Lavender ⌬ Compound: Camphor
▶ Video
and CCL2
♧ Ingredient: Lavender ⌬ Compound: Camphor
▶ Video
♧
Neem
3 active compound(s)
▸
⌬
Azadirachtin A
Angiogenesis → VEGF Signaling
▸
VEGF
♧ Ingredient: Neem ⌬ Compound: Azadirachtin A
▶ Video
⌬
Gedunin
Melanogenesis → α-MSH/MC1R Signaling
▸
MITF
♧ Ingredient: Neem ⌬ Compound: Gedunin
▶ Video
Tyrosinase
♧ Ingredient: Neem ⌬ Compound: Gedunin
▶ Video
⌬
Rutin
Tissue Remodelling → ROS/AP-1 Signaling
▸
ROS
♧ Ingredient: Neem ⌬ Compound: Rutin
▶ Video
MMP-1
♧ Ingredient: Neem ⌬ Compound: Rutin
▶ Video
♧
Thyme
1 active compound(s)
▸
⌬
Thymol
Tissue Remodelling → MAPK Signaling
▸
ROS
♧ Ingredient: Thyme ⌬ Compound: Thymol
▶ Video
MMP-1
♧ Ingredient: Thyme ⌬ Compound: Thymol
▶ Video
♧
Turmeric
1 active compound(s)
▸
⌬
Curcumin
Melanogenesis → ERK/MITF Signaling
▸
Microphthalmia‐associated transcription factor (MITF)
♧ Ingredient: Turmeric ⌬ Compound: Curcumin
▶ Video
tyrosine
♧ Ingredient: Turmeric ⌬ Compound: Curcumin
▶ Video
tyrosinase‐related protein 1 and 2 (TRP-1 and TRP-2) expression
♧ Ingredient: Turmeric ⌬ Compound: Curcumin
▶ Video