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Curcumin
Compound · in 1 ingredients · 8 conditions

Curcumin is tracked across every ingredient that carries it and mapped to the disease biology it modulates, resolving down to molecular targets and biomarkers with linked evidence.

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Comparison

All Disease Biological Process Molecular Pathway
Disease · 3 process(es) · 3 pathway(s)
Oxidative Stress1 pathway
ROS Signaling
◈ TargetROS♧ IngredientTurmeric
ROS
Neurodegeneration1 pathway
ROS Signaling
◈ TargetAß aggregation♧ IngredientTurmeric
MDA, BAX/BCL-2 Ratio, 8-OHdG, and 8 OHG
NeuroInflammation1 pathway
NF-κB Signaling
◈ TargetNF-κB♧ IngredientTurmeric
PGE2, NO, and TNF-α
Disease · 2 process(es) · 2 pathway(s)
Cell cycle progression1 pathway
p53/p21 Signaling
◈ Targetp53♧ IngredientTurmeric
CDK2, cyclin A, p53, p21
Inflammation1 pathway
NF-κB Signaling
◈ TargetNF-κB♧ IngredientTurmeric
TNF-α, IL-1, IL-6
Disease · 2 process(es) · 3 pathway(s)
Inflammation2 pathways
p38 MAPK Signaling
◈ TargetNF-κB♧ IngredientTurmeric
IL-1β
IL-1β Signaling
◈ TargetNF-κB♧ IngredientTurmeric
Occludin, ZO-1
Diabetic Cataract1 pathway
ROS/αB Crystallin aggregation Signaling
◈ TargetROS♧ IngredientTurmeric
ROS, αB Crystals
Disease · 2 process(es) · 2 pathway(s)
Inflammation1 pathway
TNFR/NF-κB Signaling
◈ TargetNF-κB♧ IngredientTurmeric
TNF-α, IL-6, IL-8
Melanogenesis1 pathway
ERK/MITF Signaling
◈ TargetERK♧ IngredientTurmeric
Microphthalmia‐associated transcription factor (MITF), tyrosine, tyrosinase‐related protein 1 and 2 (TRP-1 and TRP-2) expression
Disease · 3 process(es) · 3 pathway(s)
Hyperandrogenism1 pathway
Hormone-induced Hyperandrogenism Signaling
◈ TargetProgesterone and FSH♧ IngredientTurmeric
FSH, Progesterone, Testosterone, LH, Estradiol
Inflammation1 pathway
NF-κB Signaling
◈ TargetNF-κB♧ IngredientTurmeric
COX-2, PGE-2
Cell Proliferation1 pathway
EGFR Signaling
◈ TargetGSK-3β♧ IngredientTurmeric
AKT, GSK3β, and HER2
Disease · 1 process(es) · 3 pathway(s)
Inflammation3 pathways
Th2/Th17 Signaling
◈ TargetIL-2♧ IngredientTurmeric
IL-2
M1 Polarization Signaling
◈ TargetROS♧ IngredientTurmeric
ROS
NF-κB Signaling
◈ TargetNF-κB♧ IngredientTurmeric
TNF-α, IL-6, IL-1β, and IL-2
Disease · 1 process(es) · 1 pathway(s)
Inflammation1 pathway
TNF-α/NF-κB Signaling
◈ TargetTNF-α♧ IngredientTurmeric
IL-6, IL-2, IL-5, GM-CSF
Disease · 3 process(es) · 3 pathway(s)
Inflammation1 pathway
NF-κB Signaling
◈ TargetIκB♧ IngredientTurmeric
TNF-α, IL-8, COX-2
Autophagy1 pathway
Autophagy Signaling
◈ TargetLC3-II♧ IngredientTurmeric
LC3, ULK1, Atg7, and Atg12
Cartilage Degeneration1 pathway
IL-1β Signaling
◈ Targetp-p65♧ IngredientTurmeric
COX-2, PGE 2, MMP-3