gut-brain-health

Gut-Brain Health - Gods
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Gut-Brain Health

Disease / Phenomenon

The two-way communication between the digestive tract and the nervous system, where microbiome balance, gut signalling, and stress pathways shape mood, sleep, and calm.

Biological Processes of Gut-Brain Health

Explore the key biological processes that drive gut-brain health, from cellular mechanisms through tissue-level responses.

✣
Barrier Permeability
1 pathway(s)
▸
▣
ERK/4E-BP1 Signaling
Target: ERK
▸
ZO-1
♧ Ingredient: Aloe Vera ⌬ Compound: Aloe emodin
▶ Video
✣
Inflammation
15 pathway(s)
▸
▣
PI3K/AKT/NF-κB Signaling
Target: PI3K
▸
TNF-α
♧ Ingredient: Amla ⌬ Compound: Quercetin
▶ Video
▣
LPS/TLR4/NF-κB Signaling
Target: NF-κB
▸
TNF-α
♧ Ingredient: Cardamom ⌬ Compound: 1,8‑Cineole
▶ Video
IL-6
♧ Ingredient: Cardamom ⌬ Compound: 1,8‑Cineole
▶ Video
COX-2
♧ Ingredient: Cardamom ⌬ Compound: 1,8‑Cineole
▶ Video
▣
JNK/AP-1/NF-κB Signaling
Target: JNK
▸
IL-6
♧ Ingredient: Garlic ⌬ Compound: Alliin
▶ Video
TNF-α
♧ Ingredient: Garlic ⌬ Compound: Alliin
▶ Video
iNOS
♧ Ingredient: Garlic ⌬ Compound: Alliin
▶ Video
COX-2
♧ Ingredient: Garlic ⌬ Compound: Alliin
▶ Video
▣
NF-κB Signaling
Target: p-p65
▸
IL-1β
♧ Ingredient: Amla ⌬ Compound: Gallic Acid
▶ Video
TNF-α
♧ Ingredient: Amla ⌬ Compound: Gallic Acid
▶ Video
IFN-γ
♧ Ingredient: Amla ⌬ Compound: Gallic Acid
▶ Video
IL-8
♧ Ingredient: Amla ⌬ Compound: Gallic Acid
▶ Video
▣
MAPK/NF-κB Signaling
Target: NF-κB
▸
IL-1β
♧ Ingredient: Ginkgo biloba ⌬ Compound: Bilobalide
▶ Video
IL-6 and TNF-α
♧ Ingredient: Ginkgo biloba ⌬ Compound: Bilobalide
▶ Video
▣
NLRP3 Signaling
Target: p-AMPK
▸
TNF-α
♧ Ingredient: Amla ⌬ Compound: Vitamin C
▶ Video
IL-6
♧ Ingredient: Amla ⌬ Compound: Vitamin C
▶ Video
▣
LPS/NF-κB Signaling
Target: IDO mRNA
▸
IDO
♧ Ingredient: Oats ⌬ Compound: Ferulic Acid
▣
LPS Signaling
Target: NF-κB
▸
IL-1β
♧ Ingredient: Licorice ⌬ Compound: Isoliquiritigenin
▶ Video
COX-2
♧ Ingredient: Licorice ⌬ Compound: Isoliquiritigenin
▶ Video
iNOS
♧ Ingredient: Licorice ⌬ Compound: Isoliquiritigenin
▶ Video
and TNF-α
♧ Ingredient: Licorice ⌬ Compound: Isoliquiritigenin
▶ Video
▣
LPS/TLR4 Signaling
Target: NF-κB
▸
TNF-α
♧ Ingredient: Oats ⌬ Compound: p-Coumaric acid
IL-1IL-1β
♧ Ingredient: Oats ⌬ Compound: p-Coumaric acid
iNOS
♧ Ingredient: Oats ⌬ Compound: p-Coumaric acid
and IL-6
♧ Ingredient: Oats ⌬ Compound: p-Coumaric acid
▣
PPAR-γ Signaling
Target: PPAR-γ
▸
PPAR-γ
♧ Ingredient: Violet Flower ⌬ Compound: Rutin
▶ Video
▣
TNF-α Signaling
Target: TNF-α
▸
TNF-α
♧ Ingredient: Nutmeg ⌬ Compound: Sabinene
▶ Video
▣
TLR4 Signaling
Target: TLR4
▸
TNF-α
♧ Ingredient: Amla ⌬ Compound: Ellagic Acid
▶ Video
IL-1β
♧ Ingredient: Amla ⌬ Compound: Ellagic Acid
▶ Video
and IL-6
♧ Ingredient: Amla ⌬ Compound: Ellagic Acid
▶ Video
▣
HMGB-1/TLRs/NF-κB Signaling
Target: HMGB-1
▸
TNF-α
♧ Ingredient: Licorice ⌬ Compound: Glycyrrhizin
▶ Video
IL-1β
♧ Ingredient: Licorice ⌬ Compound: Glycyrrhizin
▶ Video
and IL-6
♧ Ingredient: Licorice ⌬ Compound: Glycyrrhizin
▶ Video
▣
Arachidonic Acid Signaling
Target: PGE2
▸
PGE2
♧ Ingredient: Licorice ⌬ Compound: Licochalcone A
▶ Video
COX
♧ Ingredient: Licorice ⌬ Compound: Licochalcone A
▶ Video
IL-6
♧ Ingredient: Licorice ⌬ Compound: Licochalcone A
▶ Video
TNFα
♧ Ingredient: Licorice ⌬ Compound: Licochalcone A
▶ Video
▣
PKA/pCREB/BDNF Signaling
Target: cAMP
▸
BDNF
♧ Ingredient: Brahmi ⌬ Compound: Asiaticoside
▶ Video
IL-1β
♧ Ingredient: Brahmi ⌬ Compound: Asiaticoside
▶ Video
IL-6 and TNF-α
♧ Ingredient: Brahmi ⌬ Compound: Asiaticoside
▶ Video
✣
Pyroptosis
1 pathway(s)
▸
▣
ROS/NLRP3 Signaling
Target: NLRP3
▸
ROS
♧ Ingredient: Aloe Vera ⌬ Compound: Aloe emodin
▶ Video
Caspase-1
♧ Ingredient: Aloe Vera ⌬ Compound: Aloe emodin
▶ Video
✣
Chemotherapy Resistance
1 pathway(s)
▸
▣
Oct4/AKT Signaling
Target: 2026-10-04 00:00:00
▸
ABCG2
♧ Ingredient: Cardamom ⌬ Compound: Cardamonin
▶ Video
✣
Apoptosis
3 pathway(s)
▸
▣
NF-κB/Caspase3/9 Signaling
Target: TSP50
▸
Caspase-3
♧ Ingredient: Cardamom ⌬ Compound: Cardamonin
▶ Video
Caspase-9
♧ Ingredient: Cardamom ⌬ Compound: Cardamonin
▶ Video
tsp50
♧ Ingredient: Cardamom ⌬ Compound: Cardamonin
▶ Video
▣
ROS/Caspase-3 Signaling
Target: ROS
▸
ROS
♧ Ingredient: Ginkgo biloba ⌬ Compound: Ginkgolic Acid
▶ Video
Caspase-3
♧ Ingredient: Ginkgo biloba ⌬ Compound: Ginkgolic Acid
▶ Video
BAX
♧ Ingredient: Ginkgo biloba ⌬ Compound: Ginkgolic Acid
▶ Video
BCL-2
♧ Ingredient: Ginkgo biloba ⌬ Compound: Ginkgolic Acid
▶ Video
▣
Intrinstic Mitochondrial Pathway
Target: Caspase-3
▸
BCL-2
♧ Ingredient: Ajwain ⌬ Compound: Carvacrol
▶ Video
BAX
♧ Ingredient: Ajwain ⌬ Compound: Carvacrol
▶ Video
Cytochrome-c
♧ Ingredient: Ajwain ⌬ Compound: Carvacrol
▶ Video
✣
Smooth Muscle Contraction
1 pathway(s)
▸
▣
Ca2+/calmodulin/MLCK Signaling
Target: Potassium Channel
▸
Intracellular Ca2+
♧ Ingredient: Coriander ⌬ Compound: Linalool
▶ Video
✣
Oxidative Stress
6 pathway(s)
▸
▣
GABA Signaling
Target: ROS
▸
ROS
♧ Ingredient: Valerian ⌬ Compound: Valepotriate
▶ Video
▣
ROS Signaling
Target: ROS
▸
ROS
♧ Ingredient: Gold Kiwifruit ⌬ Compound: Vitamin A
▣
Nrf2/Keap Signaling
Target: Nrf2
▸
HO-1
♧ Ingredient: Oats ⌬ Compound: Avenanthramide
ROS
♧ Ingredient: Oats ⌬ Compound: Avenanthramide
▣
Nrf2/HO-1 Signaling
Target: Nrf2
▸
ROS
♧ Ingredient: Amla ⌬ Compound: Ellagic Acid
▶ Video
HO-1
♧ Ingredient: Amla ⌬ Compound: Ellagic Acid
▶ Video
and NQO1
♧ Ingredient: Amla ⌬ Compound: Ellagic Acid
▶ Video
▣
Nrf2 Signaling
Target: ROS
▸
SOD
♧ Ingredient: Brahmi ⌬ Compound: Asiatic Acid
▶ Video
ROS
♧ Ingredient: Brahmi ⌬ Compound: Asiatic Acid
▶ Video
▣
NRF2 Signaling
Target: Nrf2
▸
GPX4
♧ Ingredient: Licorice ⌬ Compound: Formononetin
▶ Video
ROS
♧ Ingredient: Licorice ⌬ Compound: Formononetin
▶ Video
✣
Anxiety
4 pathway(s)
▸
▣
BDNF Signaling
Target: 5-HT, NE
▸
5-HT
♧ Ingredient: Valerian ⌬ Compound: Valerian
▶ Video
NE
♧ Ingredient: Valerian ⌬ Compound: Valerian
▶ Video
BDNF
♧ Ingredient: Valerian ⌬ Compound: Valerian
▶ Video
▣
GABAergic Signaling
Target: GAD67
▸
GAD67
♧ Ingredient: Violet Flower ⌬ Compound: Salicylic Acid
▶ Video
▣
Adenosine A2a Signaling
Target: AChE
▸
Tyrosine Hydroxylase
♧ Ingredient: Ajwain ⌬ Compound: Limonene
▶ Video
GAD-67
♧ Ingredient: Ajwain ⌬ Compound: Limonene
▶ Video
GFAP & IBA-1
♧ Ingredient: Ajwain ⌬ Compound: Limonene
▶ Video
▣
CCKB Signaling
Target: CCK receptors
▸
CCK
♧ Ingredient: Brahmi ⌬ Compound: Brahmoside
▶ Video
✣
Sleep-wake cycle
1 pathway(s)
▸
▣
5-HT Signaling
Target: Gut microbiota/Tryptophan
▸
5-HT
♧ Ingredient: Ganoderma ⌬ Compound: Lucidenic acid B
▶ Video
Tryptophan
♧ Ingredient: Ganoderma ⌬ Compound: Lucidenic acid B
▶ Video
✣
NeuroInflammation
2 pathway(s)
▸
▣
Gut Microbiome-mediated NeuroInflammatory Signaling
Target: IL-6, IL-17
▸
IL-6
♧ Ingredient: Almond ⌬ Compound: Kaempferol
IL-17
♧ Ingredient: Almond ⌬ Compound: Kaempferol
▣
HPA Axis Signaling
Target: Cortisol
▸
Cortisol
♧ Ingredient: St. John's wort ⌬ Compound: Hypericin
✣
Neurotransmitter Imbalance
2 pathway(s)
▸
▣
Neurotransmitter Signaling
Target: Serotonin
▸
GABA
♧ Ingredient: St. John's wort ⌬ Compound: Hypericin
▣
Catecholamine Signaling
Target: Dopamine
▸
Dopamine
♧ Ingredient: St. John's wort ⌬ Compound: Hypericin
✣
Impaired Neuroplasticity
1 pathway(s)
▸
▣
Nerve Growth Factor Signaling
Target: BDNF
▸
BDNF
♧ Ingredient: St. John's wort ⌬ Compound: Hypericin
✣
Neuronal Hyperexcitability
2 pathway(s)
▸
▣
NMDA Signaling
Target: NMDA Receptor
▸
Intracellular Ca2+
♧ Ingredient: Poppy Seed ⌬ Compound: Thiamine
▣
mGR Signaling
Target: mGR
▸
Anandamide
♧ Ingredient: N-acetyl cysteine ⌬ Compound: N-acetyl cysteine
✣
Neuronal Excitability
2 pathway(s)
▸
▣
GABAa Signaling
Target: GAD65
▸
GABAa
♧ Ingredient: Nardostachys jatamansi ⌬ Compound: Valepotriates
▶ Video
▣
Ca2+ Signaling
Target: SK Channel
▸
Ca2+
♧ Ingredient: Poppy Seed ⌬ Compound: Noscapine
▶ Video
✣
Relaxation
4 pathway(s)
▸
▣
GPCR Signaling
Target: A1AR
▸
A1AR
♧ Ingredient: Nardostachys jatamansi ⌬ Compound: Pinoresinol
▶ Video
▣
TRPA1/Ca Signaling
Target: TRPA1
▸
Cortisol
♧ Ingredient: Nardostachys jatamansi ⌬ Compound: β-Eudesmol
▶ Video
▣
cGMP/cAMP Signaling
Target: PDE
▸
Ca
♧ Ingredient: Poppy Seed ⌬ Compound: Papaverine
▶ Video
cAMP
♧ Ingredient: Poppy Seed ⌬ Compound: Papaverine
▶ Video
cGMP
♧ Ingredient: Poppy Seed ⌬ Compound: Papaverine
▶ Video
▣
5-HT Signaling
Target: 5-HT
▸
5-HT
♧ Ingredient: Poppy Seed ⌬ Compound: β-Sitosterol
▶ Video
✣
Neuroprotection
2 pathway(s)
▸
▣
Nrf2 Signaling
Target: Keap1
▸
HO-1
♧ Ingredient: Nardostachys jatamansi ⌬ Compound: Jatamansinol
▶ Video
NQO-1
♧ Ingredient: Nardostachys jatamansi ⌬ Compound: Jatamansinol
▶ Video
▣
BDNF/ERK Signaling
Target: ERK
▸
BDNF
♧ Ingredient: Violet Flower ⌬ Compound: Myricetin
▶ Video
✣
Sleep Regulation
1 pathway(s)
▸
▣
GABAergic Signaling
Target: GABAA Receptor
▸
Sleep Latency
♧ Ingredient: Nardostachys jatamansi ⌬ Compound: Calarene
▶ Video
✣
Sedative
1 pathway(s)
▸
▣
GABAergic Signaling
Target: GABAA Receptor
▸
Sleep Latency
♧ Ingredient: Violet Flower ⌬ Compound: Linalool
▶ Video
✣
Neuroinflammation
6 pathway(s)
▸
▣
MAPK Signaling
Target: p38 MAPK
▸
p-JNK
♧ Ingredient: Violet Flower ⌬ Compound: Kaempferol
▶ Video
p-p38 MAPK
♧ Ingredient: Violet Flower ⌬ Compound: Kaempferol
▶ Video
▣
AMPAR Signaling
Target: GluA1
▸
GluA1
♧ Ingredient: Violet Flower ⌬ Compound: Kaempferol
▶ Video
▣
NMDAR Signaling
Target: GluN2A
▸
GluN2A
♧ Ingredient: Violet Flower ⌬ Compound: Kaempferol
▶ Video
▣
NF-κB Signaling
Target: ERK1/2
▸
TNF-α
♧ Ingredient: Ajwain ⌬ Compound: Carvacrol
▶ Video
IL-1β
♧ Ingredient: Ajwain ⌬ Compound: Carvacrol
▶ Video
IL-6
♧ Ingredient: Ajwain ⌬ Compound: Carvacrol
▶ Video
TGF-β
♧ Ingredient: Ajwain ⌬ Compound: Carvacrol
▶ Video
IL-10
♧ Ingredient: Ajwain ⌬ Compound: Carvacrol
▶ Video
▣
NO Signaling
Target: NO
▸
NO
♧ Ingredient: Nutmeg ⌬ Compound: Limonene
▶ Video
▣
IL-1β/NF-κB Signaling
Target: ERK
▸
TNF-α
♧ Ingredient: Nutmeg ⌬ Compound: Macelignan
▶ Video
TGF-β
♧ Ingredient: Nutmeg ⌬ Compound: Macelignan
▶ Video
IL-10
♧ Ingredient: Nutmeg ⌬ Compound: Macelignan
▶ Video
Iba-1
♧ Ingredient: Nutmeg ⌬ Compound: Macelignan
▶ Video
✣
Sleep-Wake Cycle
2 pathway(s)
▸
▣
MT1/MT2 Signaling
Target: MT 2 Receptor
▸
Sleep Latency
♧ Ingredient: Violet Flower ⌬ Compound: Melatonin (trace)
▶ Video
SCN
♧ Ingredient: Violet Flower ⌬ Compound: Melatonin (trace)
▶ Video
NREMS
♧ Ingredient: Violet Flower ⌬ Compound: Melatonin (trace)
▶ Video
▣
MOR Signaling
Target: μ-Opioid Receptor
▸
cFOS
♧ Ingredient: Poppy Seed ⌬ Compound: Morphine (trace)
▶ Video
✣
Lipid Peroxidation
1 pathway(s)
▸
▣
Oxidative Stress Signaling
Target: ROS
▸
NO
♧ Ingredient: Ajwain ⌬ Compound: p-Cymene
▶ Video
SOD
♧ Ingredient: Ajwain ⌬ Compound: p-Cymene
▶ Video
CAT
♧ Ingredient: Ajwain ⌬ Compound: p-Cymene
▶ Video
✣
Nociception
4 pathway(s)
▸
▣
Cholinergic Signaling
Target: Cholinergic System
▸
Naloxone
♧ Ingredient: Ajwain ⌬ Compound: γ-Terpinene
▶ Video
Atropine
♧ Ingredient: Ajwain ⌬ Compound: γ-Terpinene
▶ Video
▣
Opioid Signaling
Target: Opioid System
▸
Naloxone
♧ Ingredient: Ajwain ⌬ Compound: γ-Terpinene
▶ Video
Atropine
♧ Ingredient: Ajwain ⌬ Compound: γ-Terpinene
▶ Video
▣
GABAA Signaling
Target: GABAA Receptor
▸
GABAA Receptor γ2 subunit
♧ Ingredient: Nutmeg ⌬ Compound: Eugenol
▶ Video
▣
MOR Signaling
Target: μ-Opioid Receptor
▸
Sleep Latency
♧ Ingredient: Poppy Seed ⌬ Compound: Codeine (trace)
▶ Video
✣
NREMS
1 pathway(s)
▸
▣
GABAA/BZD Signaling
Target: GABAA-Benzodiazepine receptor
▸
Flumazenil
♧ Ingredient: Ajwain ⌬ Compound: Pinene
▶ Video
✣
Depression
6 pathway(s)
▸
▣
MAO-mediated Signaling
Target: MAO
▸
Tryptamine
♧ Ingredient: Nutmeg ⌬ Compound: Myristicin
▶ Video
5-HT
♧ Ingredient: Nutmeg ⌬ Compound: Myristicin
▶ Video
▣
Serotonergic activation
Target: 5-HT2a receptor
▸
saprogrelate
♧ Ingredient: Nutmeg ⌬ Compound: Trimyristin
▶ Video
5-HT
♧ Ingredient: Nutmeg ⌬ Compound: Trimyristin
▶ Video
▣
PI3K/AKT Signaling
Target: PI3K
▸
BDNF
♧ Ingredient: Licorice ⌬ Compound: Liquiritigenin
▶ Video
▣
DAT/VMAT2 Signaling
Target: VMAT2
▸
Dopamine
♧ Ingredient: Brahmi ⌬ Compound: Asiatic Acid
▶ Video
▣
BDNF/cAMP Signaling
Target: BDNF
▸
Plasma corticosterone
♧ Ingredient: Brahmi ⌬ Compound: Bacopaside
▶ Video
Glucocorticoid receptor
♧ Ingredient: Brahmi ⌬ Compound: Bacopaside
▶ Video
▣
BDNFSignaling
Target: BDNF
▸
TNF-α
♧ Ingredient: Brahmi ⌬ Compound: β-Carotene
▶ Video
IL-6
♧ Ingredient: Brahmi ⌬ Compound: β-Carotene
▶ Video
✣
Neurogenesis
1 pathway(s)
▸
▣
BDNF/TrkB Signaling
Target: BDNF
▸
p-TrKB
♧ Ingredient: Nutmeg ⌬ Compound: Macelignan
▶ Video
BDNF
♧ Ingredient: Nutmeg ⌬ Compound: Macelignan
▶ Video
✣
Promotion of Sleep
1 pathway(s)
▸
▣
Neurotrophin Signaling
Target: LHPP
▸
5-HTP
♧ Ingredient: Amla ⌬ Compound: Cinnamic Acid
▶ Video
5-HT
♧ Ingredient: Amla ⌬ Compound: Cinnamic Acid
▶ Video
GAD67
♧ Ingredient: Amla ⌬ Compound: Cinnamic Acid
▶ Video
GABA
♧ Ingredient: Amla ⌬ Compound: Cinnamic Acid
▶ Video
GABAAR
♧ Ingredient: Amla ⌬ Compound: Cinnamic Acid
▶ Video
Glu
♧ Ingredient: Amla ⌬ Compound: Cinnamic Acid
▶ Video
✣
Neural Plasticity
1 pathway(s)
▸
▣
CREB/BDNF/Synapsin1 Signaling
Target: CREB
▸
BDNF
♧ Ingredient: Amla ⌬ Compound: Quercetin
▶ Video
Synapsin1
♧ Ingredient: Amla ⌬ Compound: Quercetin
▶ Video
✣
Improved Sleep
1 pathway(s)
▸
▣
Tryptophan hydroxylase-mediated Signaling
Target: Tryptophan Hydroxylase
▸
Sleep Latency
♧ Ingredient: Poppy Seed ⌬ Compound: α- Linoleic Acid
▶ Video
✣
Anxiousness
1 pathway(s)
▸
▣
GABA Signaling
Target: GABAA Receptor
▸
GABAA Receptor
♧ Ingredient: Licorice ⌬ Compound: Glabridin
▶ Video
✣
Neurite Outgrowth
1 pathway(s)
▸
▣
ERK1/2/AKT Signaling
Target: AKT
▸
p-CREB
♧ Ingredient: Brahmi ⌬ Compound: Madecassoside
▶ Video
p-AKT
♧ Ingredient: Brahmi ⌬ Compound: Madecassoside
▶ Video
p-ERK1/2
♧ Ingredient: Brahmi ⌬ Compound: Madecassoside
▶ Video

Compounds affecting Gut-Brain Health

Browse active compounds and their direct impact on gut-brain health biological processes, pathways, and biomarkers.

⌬
▸
✣
Inflammation
LPS/TLR4/NF-κB Signaling
▸
TNF-α
♧ Ingredient: Cardamom ⌬ Compound: 1,8‑Cineole
▶ Video
IL-6
♧ Ingredient: Cardamom ⌬ Compound: 1,8‑Cineole
▶ Video
COX-2
♧ Ingredient: Cardamom ⌬ Compound: 1,8‑Cineole
▶ Video
⌬
Alliin
From Garlic
▸
✣
Inflammation
JNK/AP-1/NF-κB Signaling
▸
IL-6
♧ Ingredient: Garlic ⌬ Compound: Alliin
▶ Video
TNF-α
♧ Ingredient: Garlic ⌬ Compound: Alliin
▶ Video
iNOS
♧ Ingredient: Garlic ⌬ Compound: Alliin
▶ Video
COX-2
♧ Ingredient: Garlic ⌬ Compound: Alliin
▶ Video
⌬
▸
✣
Barrier Permeability
ERK/4E-BP1 Signaling
▸
ZO-1
♧ Ingredient: Aloe Vera ⌬ Compound: Aloe emodin
▶ Video
✣
Pyroptosis
ROS/NLRP3 Signaling
▸
ROS
♧ Ingredient: Aloe Vera ⌬ Compound: Aloe emodin
▶ Video
Caspase-1
♧ Ingredient: Aloe Vera ⌬ Compound: Aloe emodin
▶ Video
⌬
▸
✣
Oxidative Stress
Nrf2 Signaling
▸
SOD
♧ Ingredient: Brahmi ⌬ Compound: Asiatic Acid
▶ Video
ROS
♧ Ingredient: Brahmi ⌬ Compound: Asiatic Acid
▶ Video
✣
Depression
DAT/VMAT2 Signaling
▸
Dopamine
♧ Ingredient: Brahmi ⌬ Compound: Asiatic Acid
▶ Video
⌬
▸
✣
Inflammation
PKA/pCREB/BDNF Signaling
▸
BDNF
♧ Ingredient: Brahmi ⌬ Compound: Asiaticoside
▶ Video
IL-1β
♧ Ingredient: Brahmi ⌬ Compound: Asiaticoside
▶ Video
IL-6 and TNF-α
♧ Ingredient: Brahmi ⌬ Compound: Asiaticoside
▶ Video
⌬
▸
✣
Oxidative Stress
Nrf2/Keap Signaling
▸
HO-1
♧ Ingredient: Oats ⌬ Compound: Avenanthramide
ROS
♧ Ingredient: Oats ⌬ Compound: Avenanthramide
⌬
▸
✣
Depression
BDNF/cAMP Signaling
▸
Plasma corticosterone
♧ Ingredient: Brahmi ⌬ Compound: Bacopaside
▶ Video
Glucocorticoid receptor
♧ Ingredient: Brahmi ⌬ Compound: Bacopaside
▶ Video
⌬
▸
✣
Inflammation
MAPK/NF-κB Signaling
▸
IL-1β
♧ Ingredient: Ginkgo biloba ⌬ Compound: Bilobalide
▶ Video
IL-6 and TNF-α
♧ Ingredient: Ginkgo biloba ⌬ Compound: Bilobalide
▶ Video
⌬
▸
✣
Anxiety
CCKB Signaling
▸
CCK
♧ Ingredient: Brahmi ⌬ Compound: Brahmoside
▶ Video
⌬
▸
✣
Sleep Regulation
GABAergic Signaling
▸
Sleep Latency
♧ Ingredient: Nardostachys jatamansi ⌬ Compound: Calarene
▶ Video
⌬
▸
✣
Chemotherapy Resistance
Oct4/AKT Signaling
▸
ABCG2
♧ Ingredient: Cardamom ⌬ Compound: Cardamonin
▶ Video
✣
Apoptosis
NF-κB/Caspase3/9 Signaling
▸
Caspase-3
♧ Ingredient: Cardamom ⌬ Compound: Cardamonin
▶ Video
Caspase-9
♧ Ingredient: Cardamom ⌬ Compound: Cardamonin
▶ Video
tsp50
♧ Ingredient: Cardamom ⌬ Compound: Cardamonin
▶ Video
⌬
▸
✣
Apoptosis
Intrinstic Mitochondrial Pathway
▸
BCL-2
♧ Ingredient: Ajwain ⌬ Compound: Carvacrol
▶ Video
BAX
♧ Ingredient: Ajwain ⌬ Compound: Carvacrol
▶ Video
Cytochrome-c
♧ Ingredient: Ajwain ⌬ Compound: Carvacrol
▶ Video
✣
Neuroinflammation
NF-κB Signaling
▸
TNF-α
♧ Ingredient: Ajwain ⌬ Compound: Carvacrol
▶ Video
IL-1β
♧ Ingredient: Ajwain ⌬ Compound: Carvacrol
▶ Video
IL-6
♧ Ingredient: Ajwain ⌬ Compound: Carvacrol
▶ Video
TGF-β
♧ Ingredient: Ajwain ⌬ Compound: Carvacrol
▶ Video
IL-10
♧ Ingredient: Ajwain ⌬ Compound: Carvacrol
▶ Video
⌬
▸
✣
Promotion of Sleep
Neurotrophin Signaling
▸
5-HTP
♧ Ingredient: Amla ⌬ Compound: Cinnamic Acid
▶ Video
5-HT
♧ Ingredient: Amla ⌬ Compound: Cinnamic Acid
▶ Video
GAD67
♧ Ingredient: Amla ⌬ Compound: Cinnamic Acid
▶ Video
GABA
♧ Ingredient: Amla ⌬ Compound: Cinnamic Acid
▶ Video
GABAAR
♧ Ingredient: Amla ⌬ Compound: Cinnamic Acid
▶ Video
Glu
♧ Ingredient: Amla ⌬ Compound: Cinnamic Acid
▶ Video
⌬
▸
✣
Nociception
MOR Signaling
▸
Sleep Latency
♧ Ingredient: Poppy Seed ⌬ Compound: Codeine (trace)
▶ Video
⌬
▸
✣
Inflammation
TLR4 Signaling
▸
TNF-α
♧ Ingredient: Amla ⌬ Compound: Ellagic Acid
▶ Video
IL-1β
♧ Ingredient: Amla ⌬ Compound: Ellagic Acid
▶ Video
and IL-6
♧ Ingredient: Amla ⌬ Compound: Ellagic Acid
▶ Video
✣
Oxidative Stress
Nrf2/HO-1 Signaling
▸
ROS
♧ Ingredient: Amla ⌬ Compound: Ellagic Acid
▶ Video
HO-1
♧ Ingredient: Amla ⌬ Compound: Ellagic Acid
▶ Video
and NQO1
♧ Ingredient: Amla ⌬ Compound: Ellagic Acid
▶ Video
⌬
▸
✣
Nociception
GABAA Signaling
▸
GABAA Receptor γ2 subunit
♧ Ingredient: Nutmeg ⌬ Compound: Eugenol
▶ Video
⌬
▸
✣
Inflammation
LPS/NF-κB Signaling
▸
IDO
♧ Ingredient: Oats ⌬ Compound: Ferulic Acid
⌬
▸
✣
Oxidative Stress
NRF2 Signaling
▸
GPX4
♧ Ingredient: Licorice ⌬ Compound: Formononetin
▶ Video
ROS
♧ Ingredient: Licorice ⌬ Compound: Formononetin
▶ Video
⌬
▸
✣
Inflammation
NF-κB Signaling
▸
IL-1β
♧ Ingredient: Amla ⌬ Compound: Gallic Acid
▶ Video
TNF-α
♧ Ingredient: Amla ⌬ Compound: Gallic Acid
▶ Video
IFN-γ
♧ Ingredient: Amla ⌬ Compound: Gallic Acid
▶ Video
IL-8
♧ Ingredient: Amla ⌬ Compound: Gallic Acid
▶ Video
⌬
▸
✣
Apoptosis
ROS/Caspase-3 Signaling
▸
ROS
♧ Ingredient: Ginkgo biloba ⌬ Compound: Ginkgolic Acid
▶ Video
Caspase-3
♧ Ingredient: Ginkgo biloba ⌬ Compound: Ginkgolic Acid
▶ Video
BAX
♧ Ingredient: Ginkgo biloba ⌬ Compound: Ginkgolic Acid
▶ Video
BCL-2
♧ Ingredient: Ginkgo biloba ⌬ Compound: Ginkgolic Acid
▶ Video
⌬
▸
✣
Anxiousness
GABA Signaling
▸
GABAA Receptor
♧ Ingredient: Licorice ⌬ Compound: Glabridin
▶ Video
⌬
▸
✣
Inflammation
HMGB-1/TLRs/NF-κB Signaling
▸
TNF-α
♧ Ingredient: Licorice ⌬ Compound: Glycyrrhizin
▶ Video
IL-1β
♧ Ingredient: Licorice ⌬ Compound: Glycyrrhizin
▶ Video
and IL-6
♧ Ingredient: Licorice ⌬ Compound: Glycyrrhizin
▶ Video
⌬
▸
✣
NeuroInflammation
HPA Axis Signaling
▸
Cortisol
♧ Ingredient: St. John's wort ⌬ Compound: Hypericin
✣
Neurotransmitter Imbalance
Neurotransmitter Signaling
▸
GABA
♧ Ingredient: St. John's wort ⌬ Compound: Hypericin
✣
Neurotransmitter Imbalance
Catecholamine Signaling
▸
Dopamine
♧ Ingredient: St. John's wort ⌬ Compound: Hypericin
✣
Impaired Neuroplasticity
Nerve Growth Factor Signaling
▸
BDNF
♧ Ingredient: St. John's wort ⌬ Compound: Hypericin
⌬
▸
✣
Inflammation
LPS Signaling
▸
IL-1β
♧ Ingredient: Licorice ⌬ Compound: Isoliquiritigenin
▶ Video
COX-2
♧ Ingredient: Licorice ⌬ Compound: Isoliquiritigenin
▶ Video
iNOS
♧ Ingredient: Licorice ⌬ Compound: Isoliquiritigenin
▶ Video
and TNF-α
♧ Ingredient: Licorice ⌬ Compound: Isoliquiritigenin
▶ Video
⌬
▸
✣
Neuroprotection
Nrf2 Signaling
▸
HO-1
♧ Ingredient: Nardostachys jatamansi ⌬ Compound: Jatamansinol
▶ Video
NQO-1
♧ Ingredient: Nardostachys jatamansi ⌬ Compound: Jatamansinol
▶ Video
⌬
▸
✣
NeuroInflammation
Gut Microbiome-mediated NeuroInflammatory Signaling
▸
IL-6
♧ Ingredient: Almond ⌬ Compound: Kaempferol
IL-17
♧ Ingredient: Almond ⌬ Compound: Kaempferol
✣
Neuroinflammation
MAPK Signaling
▸
p-JNK
♧ Ingredient: Violet Flower ⌬ Compound: Kaempferol
▶ Video
p-p38 MAPK
♧ Ingredient: Violet Flower ⌬ Compound: Kaempferol
▶ Video
✣
Neuroinflammation
AMPAR Signaling
▸
GluA1
♧ Ingredient: Violet Flower ⌬ Compound: Kaempferol
▶ Video
✣
Neuroinflammation
NMDAR Signaling
▸
GluN2A
♧ Ingredient: Violet Flower ⌬ Compound: Kaempferol
▶ Video
⌬
▸
✣
Inflammation
Arachidonic Acid Signaling
▸
PGE2
♧ Ingredient: Licorice ⌬ Compound: Licochalcone A
▶ Video
COX
♧ Ingredient: Licorice ⌬ Compound: Licochalcone A
▶ Video
IL-6
♧ Ingredient: Licorice ⌬ Compound: Licochalcone A
▶ Video
TNFα
♧ Ingredient: Licorice ⌬ Compound: Licochalcone A
▶ Video
⌬
▸
✣
Anxiety
Adenosine A2a Signaling
▸
Tyrosine Hydroxylase
♧ Ingredient: Ajwain ⌬ Compound: Limonene
▶ Video
GAD-67
♧ Ingredient: Ajwain ⌬ Compound: Limonene
▶ Video
GFAP & IBA-1
♧ Ingredient: Ajwain ⌬ Compound: Limonene
▶ Video
✣
Neuroinflammation
NO Signaling
▸
NO
♧ Ingredient: Nutmeg ⌬ Compound: Limonene
▶ Video
⌬
▸
✣
Smooth Muscle Contraction
Ca2+/calmodulin/MLCK Signaling
▸
Intracellular Ca2+
♧ Ingredient: Coriander ⌬ Compound: Linalool
▶ Video
✣
Sedative
GABAergic Signaling
▸
Sleep Latency
♧ Ingredient: Violet Flower ⌬ Compound: Linalool
▶ Video
⌬
▸
✣
Depression
PI3K/AKT Signaling
▸
BDNF
♧ Ingredient: Licorice ⌬ Compound: Liquiritigenin
▶ Video
⌬
▸
✣
Sleep-wake cycle
5-HT Signaling
▸
5-HT
♧ Ingredient: Ganoderma ⌬ Compound: Lucidenic acid B
▶ Video
Tryptophan
♧ Ingredient: Ganoderma ⌬ Compound: Lucidenic acid B
▶ Video
⌬
▸
✣
Neuroinflammation
IL-1β/NF-κB Signaling
▸
TNF-α
♧ Ingredient: Nutmeg ⌬ Compound: Macelignan
▶ Video
TGF-β
♧ Ingredient: Nutmeg ⌬ Compound: Macelignan
▶ Video
IL-10
♧ Ingredient: Nutmeg ⌬ Compound: Macelignan
▶ Video
Iba-1
♧ Ingredient: Nutmeg ⌬ Compound: Macelignan
▶ Video
✣
Neurogenesis
BDNF/TrkB Signaling
▸
p-TrKB
♧ Ingredient: Nutmeg ⌬ Compound: Macelignan
▶ Video
BDNF
♧ Ingredient: Nutmeg ⌬ Compound: Macelignan
▶ Video
⌬
▸
✣
Neurite Outgrowth
ERK1/2/AKT Signaling
▸
p-CREB
♧ Ingredient: Brahmi ⌬ Compound: Madecassoside
▶ Video
p-AKT
♧ Ingredient: Brahmi ⌬ Compound: Madecassoside
▶ Video
p-ERK1/2
♧ Ingredient: Brahmi ⌬ Compound: Madecassoside
▶ Video
⌬
▸
✣
Sleep-Wake Cycle
MT1/MT2 Signaling
▸
Sleep Latency
♧ Ingredient: Violet Flower ⌬ Compound: Melatonin (trace)
▶ Video
SCN
♧ Ingredient: Violet Flower ⌬ Compound: Melatonin (trace)
▶ Video
NREMS
♧ Ingredient: Violet Flower ⌬ Compound: Melatonin (trace)
▶ Video
⌬
▸
✣
Sleep-Wake Cycle
MOR Signaling
▸
cFOS
♧ Ingredient: Poppy Seed ⌬ Compound: Morphine (trace)
▶ Video
⌬
▸
✣
Neuroprotection
BDNF/ERK Signaling
▸
BDNF
♧ Ingredient: Violet Flower ⌬ Compound: Myricetin
▶ Video
⌬
▸
✣
Depression
MAO-mediated Signaling
▸
Tryptamine
♧ Ingredient: Nutmeg ⌬ Compound: Myristicin
▶ Video
5-HT
♧ Ingredient: Nutmeg ⌬ Compound: Myristicin
▶ Video
⌬
▸
✣
Neuronal Hyperexcitability
mGR Signaling
▸
Anandamide
♧ Ingredient: N-acetyl cysteine ⌬ Compound: N-acetyl cysteine
⌬
▸
✣
Neuronal Excitability
Ca2+ Signaling
▸
Ca2+
♧ Ingredient: Poppy Seed ⌬ Compound: Noscapine
▶ Video
⌬
▸
✣
Relaxation
cGMP/cAMP Signaling
▸
Ca
♧ Ingredient: Poppy Seed ⌬ Compound: Papaverine
▶ Video
cAMP
♧ Ingredient: Poppy Seed ⌬ Compound: Papaverine
▶ Video
cGMP
♧ Ingredient: Poppy Seed ⌬ Compound: Papaverine
▶ Video
⌬
Pinene
From Ajwain
▸
✣
NREMS
GABAA/BZD Signaling
▸
Flumazenil
♧ Ingredient: Ajwain ⌬ Compound: Pinene
▶ Video
⌬
▸
✣
Relaxation
GPCR Signaling
▸
A1AR
♧ Ingredient: Nardostachys jatamansi ⌬ Compound: Pinoresinol
▶ Video
⌬
▸
✣
Inflammation
PI3K/AKT/NF-κB Signaling
▸
TNF-α
♧ Ingredient: Amla ⌬ Compound: Quercetin
▶ Video
✣
Neural Plasticity
CREB/BDNF/Synapsin1 Signaling
▸
BDNF
♧ Ingredient: Amla ⌬ Compound: Quercetin
▶ Video
Synapsin1
♧ Ingredient: Amla ⌬ Compound: Quercetin
▶ Video
⌬
▸
✣
Inflammation
PPAR-γ Signaling
▸
PPAR-γ
♧ Ingredient: Violet Flower ⌬ Compound: Rutin
▶ Video
⌬
▸
✣
Inflammation
TNF-α Signaling
▸
TNF-α
♧ Ingredient: Nutmeg ⌬ Compound: Sabinene
▶ Video
⌬
▸
✣
Anxiety
GABAergic Signaling
▸
GAD67
♧ Ingredient: Violet Flower ⌬ Compound: Salicylic Acid
▶ Video
⌬
▸
✣
Neuronal Hyperexcitability
NMDA Signaling
▸
Intracellular Ca2+
♧ Ingredient: Poppy Seed ⌬ Compound: Thiamine
⌬
▸
✣
Depression
Serotonergic activation
▸
saprogrelate
♧ Ingredient: Nutmeg ⌬ Compound: Trimyristin
▶ Video
5-HT
♧ Ingredient: Nutmeg ⌬ Compound: Trimyristin
▶ Video
⌬
▸
✣
Oxidative Stress
GABA Signaling
▸
ROS
♧ Ingredient: Valerian ⌬ Compound: Valepotriate
▶ Video
⌬
▸
✣
Neuronal Excitability
GABAa Signaling
▸
GABAa
♧ Ingredient: Nardostachys jatamansi ⌬ Compound: Valepotriates
▶ Video
⌬
▸
✣
Anxiety
BDNF Signaling
▸
5-HT
♧ Ingredient: Valerian ⌬ Compound: Valerian
▶ Video
NE
♧ Ingredient: Valerian ⌬ Compound: Valerian
▶ Video
BDNF
♧ Ingredient: Valerian ⌬ Compound: Valerian
▶ Video
⌬
▸
✣
Oxidative Stress
ROS Signaling
▸
ROS
♧ Ingredient: Gold Kiwifruit ⌬ Compound: Vitamin A
⌬
▸
✣
Inflammation
NLRP3 Signaling
▸
TNF-α
♧ Ingredient: Amla ⌬ Compound: Vitamin C
▶ Video
IL-6
♧ Ingredient: Amla ⌬ Compound: Vitamin C
▶ Video
⌬
▸
✣
Inflammation
LPS/TLR4 Signaling
▸
TNF-α
♧ Ingredient: Oats ⌬ Compound: p-Coumaric acid
IL-1IL-1β
♧ Ingredient: Oats ⌬ Compound: p-Coumaric acid
iNOS
♧ Ingredient: Oats ⌬ Compound: p-Coumaric acid
and IL-6
♧ Ingredient: Oats ⌬ Compound: p-Coumaric acid
⌬
▸
✣
Lipid Peroxidation
Oxidative Stress Signaling
▸
NO
♧ Ingredient: Ajwain ⌬ Compound: p-Cymene
▶ Video
SOD
♧ Ingredient: Ajwain ⌬ Compound: p-Cymene
▶ Video
CAT
♧ Ingredient: Ajwain ⌬ Compound: p-Cymene
▶ Video
⌬
▸
✣
Improved Sleep
Tryptophan hydroxylase-mediated Signaling
▸
Sleep Latency
♧ Ingredient: Poppy Seed ⌬ Compound: α- Linoleic Acid
▶ Video
⌬
▸
✣
Depression
BDNFSignaling
▸
TNF-α
♧ Ingredient: Brahmi ⌬ Compound: β-Carotene
▶ Video
IL-6
♧ Ingredient: Brahmi ⌬ Compound: β-Carotene
▶ Video
⌬
▸
✣
Relaxation
TRPA1/Ca Signaling
▸
Cortisol
♧ Ingredient: Nardostachys jatamansi ⌬ Compound: β-Eudesmol
▶ Video
⌬
▸
✣
Relaxation
5-HT Signaling
▸
5-HT
♧ Ingredient: Poppy Seed ⌬ Compound: β-Sitosterol
▶ Video
⌬
▸
✣
Nociception
Cholinergic Signaling
▸
Naloxone
♧ Ingredient: Ajwain ⌬ Compound: γ-Terpinene
▶ Video
Atropine
♧ Ingredient: Ajwain ⌬ Compound: γ-Terpinene
▶ Video
✣
Nociception
Opioid Signaling
▸
Naloxone
♧ Ingredient: Ajwain ⌬ Compound: γ-Terpinene
▶ Video
Atropine
♧ Ingredient: Ajwain ⌬ Compound: γ-Terpinene
▶ Video

Ingredients affecting Gut-Brain Health

Explore therapeutic ingredients and their constituent compounds that modulate gut-brain health biology.

♧
Ajwain
5 active compound(s)
▸
⌬
Carvacrol
Apoptosis → Intrinstic Mitochondrial Pathway
▸
BCL-2
♧ Ingredient: Ajwain ⌬ Compound: Carvacrol
▶ Video
BAX
♧ Ingredient: Ajwain ⌬ Compound: Carvacrol
▶ Video
Cytochrome-c
♧ Ingredient: Ajwain ⌬ Compound: Carvacrol
▶ Video
⌬
Limonene
Anxiety → Adenosine A2a Signaling
▸
Tyrosine Hydroxylase
♧ Ingredient: Ajwain ⌬ Compound: Limonene
▶ Video
GAD-67
♧ Ingredient: Ajwain ⌬ Compound: Limonene
▶ Video
GFAP & IBA-1
♧ Ingredient: Ajwain ⌬ Compound: Limonene
▶ Video
⌬
p-Cymene
Lipid Peroxidation → Oxidative Stress Signaling
▸
NO
♧ Ingredient: Ajwain ⌬ Compound: p-Cymene
▶ Video
SOD
♧ Ingredient: Ajwain ⌬ Compound: p-Cymene
▶ Video
CAT
♧ Ingredient: Ajwain ⌬ Compound: p-Cymene
▶ Video
⌬
γ-Terpinene
Nociception → Cholinergic Signaling
▸
Naloxone
♧ Ingredient: Ajwain ⌬ Compound: γ-Terpinene
▶ Video
Atropine
♧ Ingredient: Ajwain ⌬ Compound: γ-Terpinene
▶ Video
⌬
Pinene
NREMS → GABAA/BZD Signaling
▸
Flumazenil
♧ Ingredient: Ajwain ⌬ Compound: Pinene
▶ Video
♧
Almond
1 active compound(s)
▸
⌬
Kaempferol
NeuroInflammation → Gut Microbiome-mediated NeuroInflammatory Signaling
▸
IL-6
♧ Ingredient: Almond ⌬ Compound: Kaempferol
IL-17
♧ Ingredient: Almond ⌬ Compound: Kaempferol
♧
Amla
5 active compound(s)
▸
⌬
Quercetin
Inflammation → PI3K/AKT/NF-κB Signaling
▸
TNF-α
♧ Ingredient: Amla ⌬ Compound: Quercetin
▶ Video
⌬
Gallic Acid
Inflammation → NF-κB Signaling
▸
IL-1β
♧ Ingredient: Amla ⌬ Compound: Gallic Acid
▶ Video
TNF-α
♧ Ingredient: Amla ⌬ Compound: Gallic Acid
▶ Video
IFN-γ
♧ Ingredient: Amla ⌬ Compound: Gallic Acid
▶ Video
IL-8
♧ Ingredient: Amla ⌬ Compound: Gallic Acid
▶ Video
⌬
Vitamin C
Inflammation → NLRP3 Signaling
▸
TNF-α
♧ Ingredient: Amla ⌬ Compound: Vitamin C
▶ Video
IL-6
♧ Ingredient: Amla ⌬ Compound: Vitamin C
▶ Video
⌬
Ellagic Acid
Inflammation → TLR4 Signaling
▸
TNF-α
♧ Ingredient: Amla ⌬ Compound: Ellagic Acid
▶ Video
IL-1β
♧ Ingredient: Amla ⌬ Compound: Ellagic Acid
▶ Video
and IL-6
♧ Ingredient: Amla ⌬ Compound: Ellagic Acid
▶ Video
⌬
Cinnamic Acid
Promotion of Sleep → Neurotrophin Signaling
▸
5-HTP
♧ Ingredient: Amla ⌬ Compound: Cinnamic Acid
▶ Video
5-HT
♧ Ingredient: Amla ⌬ Compound: Cinnamic Acid
▶ Video
GAD67
♧ Ingredient: Amla ⌬ Compound: Cinnamic Acid
▶ Video
GABA
♧ Ingredient: Amla ⌬ Compound: Cinnamic Acid
▶ Video
GABAAR
♧ Ingredient: Amla ⌬ Compound: Cinnamic Acid
▶ Video
Glu
♧ Ingredient: Amla ⌬ Compound: Cinnamic Acid
▶ Video
♧
Ashwagandha
0 active compound(s)
▸
♧
Black Cumin
0 active compound(s)
▸
♧
Brahmi
6 active compound(s)
▸
⌬
Asiaticoside
Inflammation → PKA/pCREB/BDNF Signaling
▸
BDNF
♧ Ingredient: Brahmi ⌬ Compound: Asiaticoside
▶ Video
IL-1β
♧ Ingredient: Brahmi ⌬ Compound: Asiaticoside
▶ Video
IL-6 and TNF-α
♧ Ingredient: Brahmi ⌬ Compound: Asiaticoside
▶ Video
⌬
Asiatic Acid
Oxidative Stress → Nrf2 Signaling
▸
SOD
♧ Ingredient: Brahmi ⌬ Compound: Asiatic Acid
▶ Video
ROS
♧ Ingredient: Brahmi ⌬ Compound: Asiatic Acid
▶ Video
⌬
Brahmoside
Anxiety → CCKB Signaling
▸
CCK
♧ Ingredient: Brahmi ⌬ Compound: Brahmoside
▶ Video
⌬
Bacopaside
Depression → BDNF/cAMP Signaling
▸
Plasma corticosterone
♧ Ingredient: Brahmi ⌬ Compound: Bacopaside
▶ Video
Glucocorticoid receptor
♧ Ingredient: Brahmi ⌬ Compound: Bacopaside
▶ Video
⌬
β-Carotene
Depression → BDNFSignaling
▸
TNF-α
♧ Ingredient: Brahmi ⌬ Compound: β-Carotene
▶ Video
IL-6
♧ Ingredient: Brahmi ⌬ Compound: β-Carotene
▶ Video
⌬
Madecassoside
Neurite Outgrowth → ERK1/2/AKT Signaling
▸
p-CREB
♧ Ingredient: Brahmi ⌬ Compound: Madecassoside
▶ Video
p-AKT
♧ Ingredient: Brahmi ⌬ Compound: Madecassoside
▶ Video
p-ERK1/2
♧ Ingredient: Brahmi ⌬ Compound: Madecassoside
▶ Video
♧
Ganoderma
1 active compound(s)
▸
⌬
Lucidenic acid B
Sleep-wake cycle → 5-HT Signaling
▸
5-HT
♧ Ingredient: Ganoderma ⌬ Compound: Lucidenic acid B
▶ Video
Tryptophan
♧ Ingredient: Ganoderma ⌬ Compound: Lucidenic acid B
▶ Video
♧
Gold Kiwifruit
1 active compound(s)
▸
⌬
Vitamin A
Oxidative Stress → ROS Signaling
▸
ROS
♧ Ingredient: Gold Kiwifruit ⌬ Compound: Vitamin A
♧
Grape
0 active compound(s)
▸
♧
Green Tea
0 active compound(s)
▸
♧
Jamun Fruit
0 active compound(s)
▸
♧
Licorice
6 active compound(s)
▸
⌬
Isoliquiritigenin
Inflammation → LPS Signaling
▸
IL-1β
♧ Ingredient: Licorice ⌬ Compound: Isoliquiritigenin
▶ Video
COX-2
♧ Ingredient: Licorice ⌬ Compound: Isoliquiritigenin
▶ Video
iNOS
♧ Ingredient: Licorice ⌬ Compound: Isoliquiritigenin
▶ Video
and TNF-α
♧ Ingredient: Licorice ⌬ Compound: Isoliquiritigenin
▶ Video
⌬
Glycyrrhizin
Inflammation → HMGB-1/TLRs/NF-κB Signaling
▸
TNF-α
♧ Ingredient: Licorice ⌬ Compound: Glycyrrhizin
▶ Video
IL-1β
♧ Ingredient: Licorice ⌬ Compound: Glycyrrhizin
▶ Video
and IL-6
♧ Ingredient: Licorice ⌬ Compound: Glycyrrhizin
▶ Video
⌬
Licochalcone A
Inflammation → Arachidonic Acid Signaling
▸
PGE2
♧ Ingredient: Licorice ⌬ Compound: Licochalcone A
▶ Video
COX
♧ Ingredient: Licorice ⌬ Compound: Licochalcone A
▶ Video
IL-6
♧ Ingredient: Licorice ⌬ Compound: Licochalcone A
▶ Video
TNFα
♧ Ingredient: Licorice ⌬ Compound: Licochalcone A
▶ Video
⌬
Formononetin
Oxidative Stress → NRF2 Signaling
▸
GPX4
♧ Ingredient: Licorice ⌬ Compound: Formononetin
▶ Video
ROS
♧ Ingredient: Licorice ⌬ Compound: Formononetin
▶ Video
⌬
Liquiritigenin
Depression → PI3K/AKT Signaling
▸
BDNF
♧ Ingredient: Licorice ⌬ Compound: Liquiritigenin
▶ Video
⌬
Glabridin
Anxiousness → GABA Signaling
▸
GABAA Receptor
♧ Ingredient: Licorice ⌬ Compound: Glabridin
▶ Video
♧
Milk Thistle
0 active compound(s)
▸
♧
N-acetyl cysteine
1 active compound(s)
▸
⌬
N-acetyl cysteine
Neuronal Hyperexcitability → mGR Signaling
▸
Anandamide
♧ Ingredient: N-acetyl cysteine ⌬ Compound: N-acetyl cysteine
♧
Nardostachys jatamansi
5 active compound(s)
▸
⌬
Valepotriates
Neuronal Excitability → GABAa Signaling
▸
GABAa
♧ Ingredient: Nardostachys jatamansi ⌬ Compound: Valepotriates
▶ Video
⌬
Pinoresinol
Relaxation → GPCR Signaling
▸
A1AR
♧ Ingredient: Nardostachys jatamansi ⌬ Compound: Pinoresinol
▶ Video
⌬
β-Eudesmol
Relaxation → TRPA1/Ca Signaling
▸
Cortisol
♧ Ingredient: Nardostachys jatamansi ⌬ Compound: β-Eudesmol
▶ Video
⌬
Jatamansinol
Neuroprotection → Nrf2 Signaling
▸
HO-1
♧ Ingredient: Nardostachys jatamansi ⌬ Compound: Jatamansinol
▶ Video
NQO-1
♧ Ingredient: Nardostachys jatamansi ⌬ Compound: Jatamansinol
▶ Video
⌬
Calarene
Sleep Regulation → GABAergic Signaling
▸
Sleep Latency
♧ Ingredient: Nardostachys jatamansi ⌬ Compound: Calarene
▶ Video
♧
Nutmeg
6 active compound(s)
▸
⌬
Sabinene
Inflammation → TNF-α Signaling
▸
TNF-α
♧ Ingredient: Nutmeg ⌬ Compound: Sabinene
▶ Video
⌬
Limonene
Neuroinflammation → NO Signaling
▸
NO
♧ Ingredient: Nutmeg ⌬ Compound: Limonene
▶ Video
⌬
Macelignan
Neuroinflammation → IL-1β/NF-κB Signaling
▸
TNF-α
♧ Ingredient: Nutmeg ⌬ Compound: Macelignan
▶ Video
TGF-β
♧ Ingredient: Nutmeg ⌬ Compound: Macelignan
▶ Video
IL-10
♧ Ingredient: Nutmeg ⌬ Compound: Macelignan
▶ Video
Iba-1
♧ Ingredient: Nutmeg ⌬ Compound: Macelignan
▶ Video
⌬
Eugenol
Nociception → GABAA Signaling
▸
GABAA Receptor γ2 subunit
♧ Ingredient: Nutmeg ⌬ Compound: Eugenol
▶ Video
⌬
Myristicin
Depression → MAO-mediated Signaling
▸
Tryptamine
♧ Ingredient: Nutmeg ⌬ Compound: Myristicin
▶ Video
5-HT
♧ Ingredient: Nutmeg ⌬ Compound: Myristicin
▶ Video
⌬
Trimyristin
Depression → Serotonergic activation
▸
saprogrelate
♧ Ingredient: Nutmeg ⌬ Compound: Trimyristin
▶ Video
5-HT
♧ Ingredient: Nutmeg ⌬ Compound: Trimyristin
▶ Video
♧
Oats
3 active compound(s)
▸
⌬
Ferulic Acid
Inflammation → LPS/NF-κB Signaling
▸
IDO
♧ Ingredient: Oats ⌬ Compound: Ferulic Acid
⌬
p-Coumaric acid
Inflammation → LPS/TLR4 Signaling
▸
TNF-α
♧ Ingredient: Oats ⌬ Compound: p-Coumaric acid
IL-1IL-1β
♧ Ingredient: Oats ⌬ Compound: p-Coumaric acid
iNOS
♧ Ingredient: Oats ⌬ Compound: p-Coumaric acid
and IL-6
♧ Ingredient: Oats ⌬ Compound: p-Coumaric acid
⌬
Avenanthramide
Oxidative Stress → Nrf2/Keap Signaling
▸
HO-1
♧ Ingredient: Oats ⌬ Compound: Avenanthramide
ROS
♧ Ingredient: Oats ⌬ Compound: Avenanthramide
♧
Olive
0 active compound(s)
▸
♧
Poppy Seed
7 active compound(s)
▸
⌬
Thiamine
Neuronal Hyperexcitability → NMDA Signaling
▸
Intracellular Ca2+
♧ Ingredient: Poppy Seed ⌬ Compound: Thiamine
⌬
Noscapine
Neuronal Excitability → Ca2+ Signaling
▸
Ca2+
♧ Ingredient: Poppy Seed ⌬ Compound: Noscapine
▶ Video
⌬
Papaverine
Relaxation → cGMP/cAMP Signaling
▸
Ca
♧ Ingredient: Poppy Seed ⌬ Compound: Papaverine
▶ Video
cAMP
♧ Ingredient: Poppy Seed ⌬ Compound: Papaverine
▶ Video
cGMP
♧ Ingredient: Poppy Seed ⌬ Compound: Papaverine
▶ Video
⌬
β-Sitosterol
Relaxation → 5-HT Signaling
▸
5-HT
♧ Ingredient: Poppy Seed ⌬ Compound: β-Sitosterol
▶ Video
⌬
Morphine (trace)
Sleep-Wake Cycle → MOR Signaling
▸
cFOS
♧ Ingredient: Poppy Seed ⌬ Compound: Morphine (trace)
▶ Video
⌬
Codeine (trace)
Nociception → MOR Signaling
▸
Sleep Latency
♧ Ingredient: Poppy Seed ⌬ Compound: Codeine (trace)
▶ Video
⌬
α- Linoleic Acid
Improved Sleep → Tryptophan hydroxylase-mediated Signaling
▸
Sleep Latency
♧ Ingredient: Poppy Seed ⌬ Compound: α- Linoleic Acid
▶ Video
♧
St. John's wort
1 active compound(s)
▸
⌬
Hypericin
NeuroInflammation → HPA Axis Signaling
▸
Cortisol
♧ Ingredient: St. John's wort ⌬ Compound: Hypericin
♧
Turmeric
0 active compound(s)
▸
♧
Valerian
2 active compound(s)
▸
⌬
Valepotriate
Oxidative Stress → GABA Signaling
▸
ROS
♧ Ingredient: Valerian ⌬ Compound: Valepotriate
▶ Video
⌬
Valerian
Anxiety → BDNF Signaling
▸
5-HT
♧ Ingredient: Valerian ⌬ Compound: Valerian
▶ Video
NE
♧ Ingredient: Valerian ⌬ Compound: Valerian
▶ Video
BDNF
♧ Ingredient: Valerian ⌬ Compound: Valerian
▶ Video
♧
Violet Flower
6 active compound(s)
▸
⌬
Rutin
Inflammation → PPAR-γ Signaling
▸
PPAR-γ
♧ Ingredient: Violet Flower ⌬ Compound: Rutin
▶ Video
⌬
Salicylic Acid
Anxiety → GABAergic Signaling
▸
GAD67
♧ Ingredient: Violet Flower ⌬ Compound: Salicylic Acid
▶ Video
⌬
Myricetin
Neuroprotection → BDNF/ERK Signaling
▸
BDNF
♧ Ingredient: Violet Flower ⌬ Compound: Myricetin
▶ Video
⌬
Linalool
Sedative → GABAergic Signaling
▸
Sleep Latency
♧ Ingredient: Violet Flower ⌬ Compound: Linalool
▶ Video
⌬
Kaempferol
Neuroinflammation → MAPK Signaling
▸
p-JNK
♧ Ingredient: Violet Flower ⌬ Compound: Kaempferol
▶ Video
p-p38 MAPK
♧ Ingredient: Violet Flower ⌬ Compound: Kaempferol
▶ Video
⌬
Melatonin (trace)
Sleep-Wake Cycle → MT1/MT2 Signaling
▸
Sleep Latency
♧ Ingredient: Violet Flower ⌬ Compound: Melatonin (trace)
▶ Video
SCN
♧ Ingredient: Violet Flower ⌬ Compound: Melatonin (trace)
▶ Video
NREMS
♧ Ingredient: Violet Flower ⌬ Compound: Melatonin (trace)
▶ Video