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Bowel Health
Disease / Phenomenon
The overall balance of the lower digestive tract — covering colon integrity, gut-barrier function, motility, and the resident microbiome — that keeps digestion smooth and inflammation in check.
Biological Processes of Bowel Health
Explore the key biological processes that drive bowel health, from cellular mechanisms through tissue-level responses.
Autophagy
3 pathway(s)
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Autophagy
3 pathway(s)
Inflammation
24 pathway(s)
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Inflammation
24 pathway(s)
PI3K/AKT/NF-κB Signaling
Target: PI3K/AKT
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PI3K/AKT/NF-κB Signaling
Target: PI3K/AKT
TNF-α
AhR Signaling
Target: Aryl hydrocarbon receptor (AhR)
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AhR Signaling
Target: Aryl hydrocarbon receptor (AhR)
IL-5 and IL-13
ROS/NF-κB Signaling
Target: ROS
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ROS/NF-κB Signaling
Target: ROS
ROS
TNF-α-induced iNOS Signaling
Target: NO
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TNF-α-induced iNOS Signaling
Target: NO
NO
CB2/PPAR-γ Signaling
Target: CB2
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CB2/PPAR-γ Signaling
Target: CB2
FoxP3
Apoptosis
5 pathway(s)
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Apoptosis
5 pathway(s)
ROS-induced Apoptosis Signaling
Target: ROS
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ROS-induced Apoptosis Signaling
Target: ROS
Colon contraction
1 pathway(s)
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Colon contraction
1 pathway(s)
Acetylcholine Signaling
Target: VDCC
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Acetylcholine Signaling
Target: VDCC
Intracellular Ca2+ level
Cell cycle progression
1 pathway(s)
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Cell cycle progression
1 pathway(s)
Barrier Permeability
1 pathway(s)
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Barrier Permeability
1 pathway(s)
ERK/4E-BP1 Signaling
Target: ERK
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ERK/4E-BP1 Signaling
Target: ERK
ZO-1
Chemotherapy Resistance
1 pathway(s)
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Chemotherapy Resistance
1 pathway(s)
Oct4/AKT Signaling
Target: 2026-10-04 00:00:00
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Oct4/AKT Signaling
Target: 2026-10-04 00:00:00
ABCG2
Smooth Muscle Contraction
2 pathway(s)
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Smooth Muscle Contraction
2 pathway(s)
Ca2+/calmodulin/MLCK Signaling
Target: Potassium Channel
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Ca2+/calmodulin/MLCK Signaling
Target: Potassium Channel
Intracellular Ca2+
Acetylcholine Signaling
Target: PKC-α
▸
Acetylcholine Signaling
Target: PKC-α
PKC-α
Oxidative Stress
3 pathway(s)
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Oxidative Stress
3 pathway(s)
Fat Digestion
1 pathway(s)
▸
Fat Digestion
1 pathway(s)
Carbohydrate Digestion
1 pathway(s)
▸
Carbohydrate Digestion
1 pathway(s)
Protein Digestion
1 pathway(s)
▸
Protein Digestion
1 pathway(s)
Mucus Hypersecretion
2 pathway(s)
▸
Mucus Hypersecretion
2 pathway(s)
PI3K/AKT/mTOR Signaling
Target: Mucin 2
▸
PI3K/AKT/mTOR Signaling
Target: Mucin 2
Mucin 2
Mucin Signaling
Target: Muc5ac & Muc6
▸
Mucin Signaling
Target: Muc5ac & Muc6
Muc5ac & Muc6
Gut Transit/Fecal Bulking
2 pathway(s)
▸
Gut Transit/Fecal Bulking
2 pathway(s)
GPR41 Signaling
Target: Peptide YY (PYY)
▸
GPR41 Signaling
Target: Peptide YY (PYY)
PYY
GPR43 Signaling
Target: Glucagon-like peptide 1 (GLP-1)
▸
GPR43 Signaling
Target: Glucagon-like peptide 1 (GLP-1)
GLP-1
Gastric Acid Hypersecretion
1 pathway(s)
▸
Gastric Acid Hypersecretion
1 pathway(s)
Ca2+/cAMP Signaling
Target: Histamine
▸
Ca2+/cAMP Signaling
Target: Histamine
Histamine
Epithelial-Mesenchymal Transition
1 pathway(s)
▸
Epithelial-Mesenchymal Transition
1 pathway(s)
Cell Cycle Progression
1 pathway(s)
▸
Cell Cycle Progression
1 pathway(s)
JAK/STAT3 Signaling
Target: p-JAK1/2
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JAK/STAT3 Signaling
Target: p-JAK1/2
Cycin D
Cell Cycle Invasion
1 pathway(s)
▸
Cell Cycle Invasion
1 pathway(s)
Cell Proliferation
2 pathway(s)
▸
Cell Proliferation
2 pathway(s)
Appetite Stimulation
1 pathway(s)
▸
Appetite Stimulation
1 pathway(s)
TRPA1 Signaling
Target: TRPA1
▸
TRPA1 Signaling
Target: TRPA1
Plasma ghrelin levels
Intestinal Fluid Regulation
1 pathway(s)
▸
Intestinal Fluid Regulation
1 pathway(s)
cAMP/CFTR Signaling
Target: CFTR
▸
cAMP/CFTR Signaling
Target: CFTR
Cl⁻ levels
Intestinal Barrier Dysfunction
3 pathway(s)
▸
Intestinal Barrier Dysfunction
3 pathway(s)
Intestinal Mucosal Dysfunction
1 pathway(s)
▸
Intestinal Mucosal Dysfunction
1 pathway(s)
LPS/NF-κB Signaling
Target: NF-κB
▸
LPS/NF-κB Signaling
Target: NF-κB
MUC2
Compounds affecting Bowel Health
Browse active compounds and their direct impact on bowel health biological processes, pathways, and biomarkers.
From Cardamom
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From Cardamom
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From Aloe Vera
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From Aloe Vera
▸
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From Ginkgo biloba
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From Ginkgo biloba
From Cardamom
▸
From Cardamom
From Cinnamon
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From Cinnamon
▸
▸
▸
▸
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From Coriander Seed
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From Coriander Seed
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▸
▸
▸
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Inflammation
AhR Signaling
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Inflammation
AhR Signaling
IL-5 and IL-13
From Gold Kiwifruit
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From Gold Kiwifruit
Mucus Hypersecretion
PI3K/AKT/mTOR Signaling
▸
Mucus Hypersecretion
PI3K/AKT/mTOR Signaling
Mucin 2
From Coriander Seed
▸
From Coriander Seed
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From Peppermint
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From Peppermint
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From Vettiver
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From Vettiver
From Black Pepper
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From Black Pepper
Carbohydrate Digestion
Carbohydrate Metabolic Signaling
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Carbohydrate Digestion
Carbohydrate Metabolic Signaling
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From Gold Kiwifruit
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From Gold Kiwifruit
Gut Transit/Fecal Bulking
GPR41 Signaling
▸
Gut Transit/Fecal Bulking
GPR41 Signaling
PYY
Gut Transit/Fecal Bulking
GPR43 Signaling
▸
Gut Transit/Fecal Bulking
GPR43 Signaling
GLP-1
From Coriander Seed
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From Coriander Seed
From Vettiver
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From Vettiver
Cell Proliferation
JAK/STAT Signaling
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Cell Proliferation
JAK/STAT Signaling
STAT3
From Phyllanthus niruri
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From Phyllanthus niruri
From Long Pepper
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From Long Pepper
From Gold Kiwifruit
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From Gold Kiwifruit
Inflammation
TNF-α-induced iNOS Signaling
▸
Inflammation
TNF-α-induced iNOS Signaling
NO
From Gold Kiwifruit
▸
From Gold Kiwifruit
Inflammation
ROS/NF-κB Signaling
▸
Inflammation
ROS/NF-κB Signaling
ROS
From Nut Grass
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From Nut Grass
From Coriander Seed
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From Coriander Seed
From Vettiver
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From Vettiver
Cell Proliferation
AKT Signaling
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Cell Proliferation
AKT Signaling
AKT1
From Nut Grass
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From Nut Grass
Inflammation
CB2/PPAR-γ Signaling
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Inflammation
CB2/PPAR-γ Signaling
FoxP3
From Vettiver
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From Vettiver
From Long Pepper
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From Long Pepper
Ingredients affecting Bowel Health
Explore therapeutic ingredients and their constituent compounds that modulate bowel health biology.
1 active compound(s)
▸
1 active compound(s)
Inflammation → PI3K/AKT/NF-κB Signaling
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Inflammation → PI3K/AKT/NF-κB Signaling
TNF-α
1 active compound(s)
▸
1 active compound(s)
2 active compound(s)
▸
2 active compound(s)
Inflammation → LPS/TLR4/NF-κB Signaling
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Inflammation → LPS/TLR4/NF-κB Signaling
Apoptosis → NF-κB/Caspase3/9 Signaling
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Apoptosis → NF-κB/Caspase3/9 Signaling
1 active compound(s)
▸
1 active compound(s)
Meabolic Dysregulation → GLP-1 Signaling
▸
Meabolic Dysregulation → GLP-1 Signaling
1 active compound(s)
▸
1 active compound(s)
4 active compound(s)
▸
4 active compound(s)
Inflammation → NLRP3 Signaling
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Inflammation → NLRP3 Signaling
0 active compound(s)
▸
0 active compound(s)
1 active compound(s)
▸
1 active compound(s)
2 active compound(s)
▸
2 active compound(s)
2 active compound(s)
▸
2 active compound(s)
Inflammation → MAPK/NF-κB Signaling
▸
Inflammation → MAPK/NF-κB Signaling
Apoptosis → ROS/Caspase-3 Signaling
▸
Apoptosis → ROS/Caspase-3 Signaling
5 active compound(s)
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5 active compound(s)
Inflammation → ROS/NF-κB Signaling
▸
Inflammation → ROS/NF-κB Signaling
ROS
Inflammation → TNF-α-induced iNOS Signaling
▸
Inflammation → TNF-α-induced iNOS Signaling
NO
Smooth Muscle Contraction → Acetylcholine Signaling
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Smooth Muscle Contraction → Acetylcholine Signaling
PKC-α
Mucus Hypersecretion → PI3K/AKT/mTOR Signaling
▸
Mucus Hypersecretion → PI3K/AKT/mTOR Signaling
Mucin 2
Gut Transit/Fecal Bulking → GPR41 Signaling
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Gut Transit/Fecal Bulking → GPR41 Signaling
PYY
1 active compound(s)
▸
1 active compound(s)
Inflammation → Nrf2/ARE Signaling
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Inflammation → Nrf2/ARE Signaling
0 active compound(s)
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0 active compound(s)
1 active compound(s)
▸
1 active compound(s)
0 active compound(s)
▸
0 active compound(s)
3 active compound(s)
▸
3 active compound(s)
Autophagy → AKT/mTOR Signaling
▸
Autophagy → AKT/mTOR Signaling
Cell Cycle Progression → JAK/STAT3 Signaling
▸
Cell Cycle Progression → JAK/STAT3 Signaling
Cycin D
Angiogenesis → NF-κB Signaling
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Angiogenesis → NF-κB Signaling
6 active compound(s)
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6 active compound(s)
Inflammation → IL-6/TNF-α Signalling
▸
Inflammation → IL-6/TNF-α Signalling
Inflammation → CB2/PPAR-γ Signaling
▸
Inflammation → CB2/PPAR-γ Signaling
FoxP3
1 active compound(s)
▸
1 active compound(s)
Autophagy → IRE1 Signaling
▸
Autophagy → IRE1 Signaling
1 active compound(s)
▸
1 active compound(s)
5 active compound(s)
▸
5 active compound(s)
Inflammation → LPS/TLR4 Signaling
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Inflammation → LPS/TLR4 Signaling
Inflammation → LPS/NF-κB Signaling
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Inflammation → LPS/NF-κB Signaling
Inflammation → Stress Hormone-induced Inflammatory Signaling
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Inflammation → Stress Hormone-induced Inflammatory Signaling
0 active compound(s)
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0 active compound(s)
1 active compound(s)
▸
1 active compound(s)
5 active compound(s)
▸
5 active compound(s)
Inflammation → Nrf2 Signaling
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Inflammation → Nrf2 Signaling
Cell Proliferation → AKT Signaling
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Cell Proliferation → AKT Signaling
AKT1
Cell Proliferation → JAK/STAT Signaling
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Cell Proliferation → JAK/STAT Signaling
STAT3
Appetite Stimulation → TRPA1 Signaling
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Appetite Stimulation → TRPA1 Signaling
Plasma ghrelin levels
Intestinal Barrier Dysfunction → SCFAs-mediated Signaling
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Intestinal Barrier Dysfunction → SCFAs-mediated Signaling