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Curcumin
Compound · in 1 ingredients · 8 conditions

Curcumin is tracked across every ingredient that carries it and mapped to the disease biology it modulates, resolving down to molecular targets and biomarkers with linked evidence.

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Comparison

All Disease Biological Process Molecular Pathway
❀
Disease · 3 process(es) · 3 pathway(s)
▸
▸✣ Oxidative Stress1 pathway
▸▣ ROS Signaling
◈ TargetROS♧ IngredientTurmeric
◆ROS
▸✣ Neurodegeneration1 pathway
▸▣ ROS Signaling
◈ TargetAß aggregation♧ IngredientTurmeric
◆MDA, BAX/BCL-2 Ratio, 8-OHdG, and 8 OHG
▸✣ NeuroInflammation1 pathway
▸▣ NF-κB Signaling
◈ TargetNF-κB♧ IngredientTurmeric
◆PGE2, NO, and TNF-α
❀
Disease · 2 process(es) · 2 pathway(s)
▸
▸✣ Cell cycle progression1 pathway
▸▣ p53/p21 Signaling
◈ Targetp53♧ IngredientTurmeric
◆CDK2, cyclin A, p53, p21
▸✣ Inflammation1 pathway
▸▣ NF-κB Signaling
◈ TargetNF-κB♧ IngredientTurmeric
◆TNF-α, IL-1, IL-6
❀
Disease · 2 process(es) · 3 pathway(s)
▸
▸✣ Inflammation2 pathways
▸▣ p38 MAPK Signaling
◈ TargetNF-κB♧ IngredientTurmeric
◆IL-1β
▸▣ IL-1β Signaling
◈ TargetNF-κB♧ IngredientTurmeric
◆Occludin, ZO-1
▸✣ Diabetic Cataract1 pathway
▸▣ ROS/αB Crystallin aggregation Signaling
◈ TargetROS♧ IngredientTurmeric
◆ROS, αB Crystals
❀
Disease · 2 process(es) · 2 pathway(s)
▸
▸✣ Inflammation1 pathway
▸▣ TNFR/NF-κB Signaling
◈ TargetNF-κB♧ IngredientTurmeric
◆TNF-α, IL-6, IL-8
▸✣ Melanogenesis1 pathway
▸▣ ERK/MITF Signaling
◈ TargetERK♧ IngredientTurmeric
◆Microphthalmia‐associated transcription factor (MITF), tyrosine, tyrosinase‐related protein 1 and 2 (TRP-1 and TRP-2) expression
❀
Disease · 3 process(es) · 3 pathway(s)
▸
▸✣ Hyperandrogenism1 pathway
▸▣ Hormone-induced Hyperandrogenism Signaling
◈ TargetProgesterone and FSH♧ IngredientTurmeric
◆FSH, Progesterone, Testosterone, LH, Estradiol
▸✣ Inflammation1 pathway
▸▣ NF-κB Signaling
◈ TargetNF-κB♧ IngredientTurmeric
◆COX-2, PGE-2
▸✣ Cell Proliferation1 pathway
▸▣ EGFR Signaling
◈ TargetGSK-3β♧ IngredientTurmeric
◆AKT, GSK3β, and HER2
❀
Disease · 1 process(es) · 3 pathway(s)
▸
▸✣ Inflammation3 pathways
▸▣ Th2/Th17 Signaling
◈ TargetIL-2♧ IngredientTurmeric
◆IL-2
▸▣ M1 Polarization Signaling
◈ TargetROS♧ IngredientTurmeric
◆ROS
▸▣ NF-κB Signaling
◈ TargetNF-κB♧ IngredientTurmeric
◆TNF-α, IL-6, IL-1β, and IL-2
❀
Disease · 1 process(es) · 1 pathway(s)
▸
▸✣ Inflammation1 pathway
▸▣ TNF-α/NF-κB Signaling
◈ TargetTNF-α♧ IngredientTurmeric
◆IL-6, IL-2, IL-5, GM-CSF
❀
Disease · 3 process(es) · 3 pathway(s)
▸
▸✣ Inflammation1 pathway
▸▣ NF-κB Signaling
◈ TargetIκB♧ IngredientTurmeric
◆TNF-α, IL-8, COX-2
▸✣ Autophagy1 pathway
▸▣ Autophagy Signaling
◈ TargetLC3-II♧ IngredientTurmeric
◆LC3, ULK1, Atg7, and Atg12
▸✣ Cartilage Degeneration1 pathway
▸▣ IL-1β Signaling
◈ Targetp-p65♧ IngredientTurmeric
◆COX-2, PGE 2, MMP-3