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ALS Test Page

GODS ALS System
Disease Single Template • ALS

Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis is represented here as an interlinked disease system involving neurodegeneration, neuroinflammation, calcium influx, glutamate excitotoxicity, extrinsic apoptosis, proteostasis stress, and muscle atrophy. This single-page Elementor version connects compounds, ingredients, molecular targets, biological pathways, biomarkers, and compound-on-disease rating pages using working anchor interlinks.

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Interlinking is handled with Elementor-safe anchor links. No JavaScript is required, so all links work inside one HTML widget.
ALS Biological System Summary
PhenomenonMotor Neuron Degeneration and Neuromuscular Decline
ProcessesNeurodegeneration, Neuroinflammation, Calcium Influx, Muscle Atrophy, Glutamate Excitotoxicity, Extrinsic Apoptosis, Proteostasis Stress
PathwaysNO-PGE2 Pathway, NF-kB Pathway, JAK1/2-STAT3 Pathway, Extrinsic Apoptotic Pathway, Glutamate Excitotoxicity, Akt/FoxO Pathway, Nrf2 Antioxidant Response
BiomarkersIL-6, TNF-alpha, IL-1B, iNOS, CHOP, MuRF1, MyHC, Calcium Influx Endpoints, Research-only Endpoints
Disease → Compounds Disease → Ingredients Disease → Ratings
ALS Disease Pipeline

Phenomenon → Process → Pathway → Biomarker

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Phenomenon
Motor Neuron Degeneration

High-level ALS disease phenomenon involving progressive decline in motor neuron function and neuromuscular integrity.

Processes
ALS Mechanisms

Neurodegeneration, neuroinflammation, calcium influx, glutamate excitotoxicity, apoptosis, and muscle atrophy.

Pathways
Molecular Circuits

NF-kB, JAK/STAT, NO-PGE2, Nrf2, Akt/FoxO, extrinsic apoptosis, and glutamate excitotoxicity.

Biomarkers
Measured Outputs

IL-6, TNF-alpha, IL-1B, iNOS, CHOP, MuRF1, MyHC, and research-only endpoints.

Ingredient Pages

Ingredients Connected to ALS Compounds

Each ingredient card links to its associated compound card, matching the ACF relationship: Ingredient → Associated Compounds.

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Ingredient CPT • Click to Compound
Parsley

Petroselinum crispum

Parent ingredient source for Apigenin.

Apigenin
Ingredient CPT • Click to Compound
Ashwagandha

Withania somnifera

Parent botanical source for Withanolide.

Withanolide
Ingredient CPT • Click to Compound
Mushroom / Fungal Sources

Ergothioneine-rich dietary sources.

Parent source group for Ergothioneine.

Ergothioneine
Ingredient CPT • Click to Compound
Baikal Skullcap

Scutellaria baicalensis

Parent ingredient source for Baicalin.

Baicalin
Ingredient CPT • Click to Compound
Grape / Japanese Knotweed

Vitis vinifera / Polygonum cuspidatum

Parent source group for Resveratrol.

Resveratrol
Ingredient CPT • Click to Compound
Rice Bran / Cereal Brans

Ferulic-acid-rich plant sources.

Parent source group for Ferulic Acid.

Ferulic Acid
Ingredient CPT • Click to Compound
Coenzyme Q10

Ubiquinone.

Nutrient-like compound source connected to TDP-43 and CHOP biology.

CoQ10
Ingredient CPT • Click to Compound
Onion / Apple / Capers

Quercetin-rich plant sources.

Parent source group for Quercetin.

Quercetin
Compound Pages

Compounds Acting on ALS Biology

Each compound card links to its Compound-on-ALS rating page, matching the relationship: Compound → Rating Page → ALS.

Back to Ingredients
Compound CPT • Click to Rating
Apigenin

Ingredient: Parsley

Processes: Neurodegeneration, Neuroinflammation, Calcium Influx, Muscle Atrophy

Targets: NLRP3 Inflammasome, JAK1/2-STAT3, Caspase 8/3, IL-1B, GluA2-lacking AMPA Receptors, MuRF1, MyHC

86/100NF-kBAkt/FoxO
Compound CPT • Click to Rating
Withanolide

Ingredient: Ashwagandha

Processes: Neuroinflammation

Targets: NF-kB, Nrf2

78/100TNF-alphaIL-6iNOS
Compound CPT • Click to Rating
Ergothioneine

Ingredient: Mushroom / Fungal Sources

Processes: Neuroinflammation

Targets: NF-kB, Nrf2

76/100TNF-alphaIL-6iNOS
Compound CPT • Click to Rating
Baicalin

Ingredient: Baikal Skullcap

Processes: Neuroinflammation

Targets: NF-kB

72/100TNF-alphaIL-6
Compound CPT • Click to Rating
Resveratrol

Ingredient: Grape / Japanese Knotweed

Processes: Neuroinflammation

Targets: NF-kB

70/100TNF-alphaIL-6
Compound CPT • Click to Rating
Ferulic Acid

Ingredient: Rice Bran / Cereal Brans

Processes: Neuroinflammation

Targets: NF-kB

68/100TNF-alphaIL-6
Compound CPT • Click to Rating
CoQ10

Ingredient: Coenzyme Q10

Process: Neurodegeneration

Target: Mislocalized TDP-43

64/100CHOP
Compound CPT • Click to Rating
Quercetin

Ingredient: Onion / Apple / Capers

Process: Neurodegeneration

Target: Mislocalized TDP-43

64/100CHOP
Pathway and Biomarker Map

Reusable Targets, Pathways, and Biomarkers

Back to Compounds
Pathway CPT
NF-kB Pathway

Linked to Apigenin, Withanolide, Ergothioneine, Baicalin, Resveratrol, and Ferulic Acid.
Pathway CPT
NO-PGE2 Pathway

Linked to Apigenin and NLRP3 Inflammasome in neurodegeneration context.
Pathway CPT
Extrinsic Apoptotic Pathway

Linked to Apigenin, Caspase 8/3, and TNF-alpha.
Pathway CPT
Glutamate Excitotoxicity

Linked to Apigenin and GluA2-lacking AMPA Receptors.
Pathway CPT
Akt/FoxO Pathway

Linked to Apigenin and MuRF1 in muscle atrophy.
Biomarker CPT
IL-6

Neuroinflammation biomarker linked to Apigenin, Withanolide, Ergothioneine, Baicalin, Resveratrol, and Ferulic Acid.
Biomarker CPT
TNF-alpha

Inflammatory biomarker linked across neuroinflammation and apoptosis-related mechanisms.
Biomarker CPT
CHOP

Proteostasis / ER stress endpoint linked to CoQ10, Quercetin, and mislocalized TDP-43.
Compound on Disease Rating Pages

Compounds on ALS Ranking

Each bottle card links to its dedicated Compound-on-ALS rating page section below.

Back to Compounds
#1
Compound on Disease
Apigenin
on
ALS
86 / 100
Compound-on-Disease CPT
Apigenin on ALS
86/100

Strong multi-process overlap across neurodegeneration, neuroinflammation, calcium influx, and muscle atrophy.

Open Rating
#2
Compound on Disease
Withanolide
on
ALS
78 / 100
Compound-on-Disease CPT
Withanolide on ALS
78/100

Neuroinflammation overlap through NF-kB, Nrf2, TNF-alpha, IL-6, and iNOS.

Open Rating
#3
Compound on Disease
Ergothioneine
on
ALS
76 / 100
Compound-on-Disease CPT
Ergothioneine on ALS
76/100

Neuroinflammatory and antioxidant-response overlap.

Open Rating
#4
Compound on Disease
Baicalin
on
ALS
72 / 100
Compound-on-Disease CPT
Baicalin on ALS
72/100

NF-kB, TNF-alpha, and IL-6 neuroinflammatory overlap.

Open Rating
#5
Compound on Disease
Resveratrol
on
ALS
70 / 100
Compound-on-Disease CPT
Resveratrol on ALS
70/100

NF-kB cytokine overlap with TNF-alpha and IL-6.

Open Rating
#6
Compound on Disease
Ferulic Acid
on
ALS
68 / 100
Compound-on-Disease CPT
Ferulic Acid on ALS
68/100

NF-kB cytokine overlap with neuroinflammatory biomarkers.

Open Rating
#7
Compound on Disease
CoQ10
on
ALS
64 / 100
Compound-on-Disease CPT
CoQ10 on ALS
64/100

TDP-43 and CHOP proteostasis endpoint overlap.

Open Rating
#8
Compound on Disease
Quercetin
on
ALS
64 / 100
Compound-on-Disease CPT
Quercetin on ALS
64/100

TDP-43 and CHOP proteostasis endpoint overlap.

Open Rating
Rating Page

Apigenin on ALS

Back to RatingsBack to Compound

Apigenin scores highest because it links to multiple ALS biological processes: neurodegeneration, neuroinflammation, calcium influx, and muscle atrophy.

Rating → ALSRating → CompoundRating → Pathways
86
/ 100
Compound-ALS Fit
Target Match
92

NLRP3, JAK/STAT, Caspase 8/3, IL-1B, AMPA receptors, MuRF1, MyHC.

Pathway Match
88

NO-PGE2, NF-kB, extrinsic apoptosis, glutamate excitotoxicity, Akt/FoxO.

Biomarker Match
82

IL-6, TNF-alpha, IL-1B, research-only endpoints.

Process Match
86

Broad process coverage across ALS mechanisms.

Compound
Apigenin

Parent ingredient: Parsley.

Targets
Molecular Targets

NLRP3 Inflammasome, JAK1/2-STAT3, Caspase 8/3, IL-1B, GluA2-lacking AMPA Receptors, MuRF1, MyHC.

Pathways
Pathway Map

NO-PGE2, NF-kB, Extrinsic Apoptotic, Glutamate Excitotoxicity, Akt/FoxO.

Biomarkers
Endpoint Outputs

IL-6, TNF-alpha, IL-1B, research-only endpoints.

Disease
ALS

Amyotrophic Lateral Sclerosis disease system.

Rating Page

Withanolide on ALS

Back to RatingsBack to Compound

Withanolide maps to ALS neuroinflammation through NF-kB, Nrf2, TNF-alpha, iNOS, and IL-6.

Rating → ALSRating → Compound
78
/ 100
Compound-ALS Fit
Rating Page

Ergothioneine on ALS

Back to RatingsBack to Compound

Ergothioneine maps to neuroinflammation and antioxidant-response biology through NF-kB, Nrf2, TNF-alpha, iNOS, and IL-6.

Rating → ALSRating → Compound
76
/ 100
Compound-ALS Fit
Rating Page

Baicalin on ALS

Back to RatingsBack to Compound

Baicalin maps to NF-kB-linked neuroinflammation with TNF-alpha and IL-6 outputs.

Rating → ALSRating → Compound
72
/ 100
Compound-ALS Fit
Rating Page

Resveratrol on ALS

Back to RatingsBack to Compound

Resveratrol maps to NF-kB-mediated neuroinflammation through TNF-alpha and IL-6 outputs.

Rating → ALSRating → Compound
70
/ 100
Compound-ALS Fit
Rating Page

Ferulic Acid on ALS

Back to RatingsBack to Compound

Ferulic Acid maps to NF-kB neuroinflammatory biology with TNF-alpha and IL-6 endpoints.

Rating → ALSRating → Compound
68
/ 100
Compound-ALS Fit
Rating Page

CoQ10 on ALS

Back to RatingsBack to Compound

CoQ10 maps to neurodegeneration through mislocalized TDP-43 and CHOP endpoint biology.

Rating → ALSRating → Compound
64
/ 100
Compound-ALS Fit
Rating Page

Quercetin on ALS

Back to RatingsBack to Compound

Quercetin maps to neurodegeneration through mislocalized TDP-43 and CHOP endpoint biology.

Rating → ALSRating → Compound
64
/ 100
Compound-ALS Fit