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ALS Interactive Disease Map ✦
Disease Page • ALS

Amyotrophic Lateral Sclerosis (ALS)

Amyotrophic lateral sclerosis (ALS), sometimes called Lou Gehrig's disease, is a progressive neurodegenerative disorder. It affects motor neurons in the brain and spinal cord, causing muscles to weaken, twitch, and waste away. The disease leads to the eventual loss of voluntary movement, speech, swallowing, and breathing

◈Disease✣Biological Processes▣Molecular Pathways◆Biomarkers
ALS systems architecture
ALS Systems Architecture
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Neuroinflammation
Neuroinflammation in Amyotrophic Lateral Sclerosis (ALS) refers to the harmful, chronic immune response in the brain and spinal cord. While ALS primarily involves the death of motor neurons, research indicates that disea
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NF-κB Pathway
Molecular pathway connected to Neuroinflammation
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◆ IL-6
Biomarker linked to NF-κB Pathway.
Process: NeuroinflammationPathway: NF-κB Pathway
◆ TNFα
Biomarker linked to NF-κB Pathway.
Process: NeuroinflammationPathway: NF-κB Pathway
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Glutamate Excitotoxicity
Molecular pathway connected to Neuroinflammation
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◆ IL-1B
Biomarker linked to Glutamate Excitotoxicity.
Process: NeuroinflammationPathway: Glutamate Excitotoxicity
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Nrf2 Pathway
Molecular pathway connected to Neuroinflammation
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◆ iNOS
Biomarker linked to Nrf2 Pathway.
Process: NeuroinflammationPathway: Nrf2 Pathway
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TLR Pathway
Molecular pathway connected to Neuroinflammation
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◆ TNFα
Biomarker linked to TLR Pathway.
Process: NeuroinflammationPathway: TLR Pathway
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Nrf2/HO-1 Pathway
Molecular pathway connected to Neuroinflammation
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◆ iNOS
Biomarker linked to Nrf2/HO-1 Pathway.
Process: NeuroinflammationPathway: Nrf2/HO-1 Pathway
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TLR4 Pathway
Molecular pathway connected to Neuroinflammation
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◆ TNF-α
Biomarker linked to TLR4 Pathway.
Process: NeuroinflammationPathway: TLR4 Pathway
◆ IL-6
Biomarker linked to TLR4 Pathway.
Process: NeuroinflammationPathway: TLR4 Pathway
◆ TNFα
Biomarker linked to TLR4 Pathway.
Process: NeuroinflammationPathway: TLR4 Pathway
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TLR4/MyD88/NF-κB Pathway
Molecular pathway connected to Neuroinflammation
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◆ TNF-α
Biomarker linked to TLR4/MyD88/NF-κB Pathway.
Process: NeuroinflammationPathway: TLR4/MyD88/NF-κB Pathway
◆ IL-6
Biomarker linked to TLR4/MyD88/NF-κB Pathway.
Process: NeuroinflammationPathway: TLR4/MyD88/NF-κB Pathway
◆ TNFα
Biomarker linked to TLR4/MyD88/NF-κB Pathway.
Process: NeuroinflammationPathway: TLR4/MyD88/NF-κB Pathway
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IL-6 Signaling Pathway
Molecular pathway connected to Neuroinflammation
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◆ IL-6
Biomarker linked to IL-6 Signaling Pathway.
Process: NeuroinflammationPathway: IL-6 Signaling Pathway
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IL-1β Signaling
Molecular pathway connected to Neuroinflammation
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◆ IL-1β
Biomarker linked to IL-1β Signaling.
Process: NeuroinflammationPathway: IL-1β Signaling
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Jak/STAT signaling pathway
Molecular pathway connected to Neuroinflammation
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◆ IL-6
Biomarker linked to Jak/STAT signaling pathway.
Process: NeuroinflammationPathway: Jak/STAT signaling pathway
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TNF-α pathway
Molecular pathway connected to Neuroinflammation
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◆ TNFα
Biomarker linked to TNF-α pathway.
Process: NeuroinflammationPathway: TNF-α pathway
◆ TNF-α
Biomarker linked to TNF-α pathway.
Process: NeuroinflammationPathway: TNF-α pathway
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IL-6 pathway
Molecular pathway connected to Neuroinflammation
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◆ IL-6
Biomarker linked to IL-6 pathway.
Process: NeuroinflammationPathway: IL-6 pathway
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Neurodegeneration
Neurodegeneration is the progressive, irreversible loss of structure and function of neurons (nerve cells) in the brain and spinal cord. Because these cells cannot regenerate, this deterioration leads to permanent cognit
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Extrinsic Apoptotic Pathway
Molecular pathway connected to Neurodegeneration
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◆ TNF-α
Biomarker linked to Extrinsic Apoptotic Pathway.
Process: NeurodegenerationPathway: Extrinsic Apoptotic Pathway
◆ TNF-a
Biomarker linked to Extrinsic Apoptotic Pathway.
Process: NeurodegenerationPathway: Extrinsic Apoptotic Pathway
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ER Stress Pathway
Molecular pathway connected to Neurodegeneration
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◆ CHOP
Biomarker linked to ER Stress Pathway.
Process: NeurodegenerationPathway: ER Stress Pathway
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NO-PGE2 Pathway
Molecular pathway connected to Neurodegeneration
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No biomarker mapped for this pathway.
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Glutamate Excitotoxicity
Molecular pathway connected to Neurodegeneration
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◆ Intracellular Calcium
Biomarker linked to Glutamate Excitotoxicity.
Process: NeurodegenerationPathway: Glutamate Excitotoxicity
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Muscle Atrophy
Muscle atrophy is the loss or thinning of muscle tissue, leading to decreased muscle mass, strength, and impaired mobility. It typically occurs due to physical inactivity (disuse), aging, malnutrition, or underlying medi
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Akt/FoxO Pathway
Molecular pathway connected to Muscle Atrophy
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◆ p-Akt
Biomarker linked to Akt/FoxO Pathway.
Process: Muscle AtrophyPathway: Akt/FoxO Pathway
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MuRF1 Pathway
Molecular pathway connected to Muscle Atrophy
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◆ MyHC
Biomarker linked to MuRF1 Pathway.
Process: Muscle AtrophyPathway: MuRF1 Pathway
GODS | ALS → Biological Process → Molecular Pathway → Biomarker