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Withanolide · Compound · GODS.com
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Withanolide

Withanolide is one of 22 compounds indexed in the ALS scoring workbook. It is measured against the 4-tier CytoSolve hierarchy: Tier 1 disease (Amyotrophic Lateral Sclerosis) → biological processes (3) → molecular pathways (5) → Tier 4 biomarkers (8). This page surfaces every measurement field from the workbook plus the source ingredients carrying this compound.

ALS Disease Rating
21.98
Interpretation
Low efficacy
Test Dosage
30 mg
Biomarker
8

Diseases this compound is indexed against

Tier 1 · macro-level biological phenomena

#1
Amyotrophic Lateral Sclerosis (ALS)
Lou Gehrig's disease · 3 processes · 5 pathways · 8 biomarkers
21.98

Ingredients containing Withanolide

Whole-food and botanical sources of this compound · 1 ingredient

◇
Ashwagandha
Source of Withanolide · inherits 21.98/100 ALS rating
21.98

Biological Processes · Pathways · Biomarkers

4-tier drill-down · click any node to expand the next tier

✣
Neuroinflammation
2 pathways
29.65
›
◇
IL-6 Signaling
3 biomarkers
59.30
›
◆ IL-6
Tier 4 biomarker — desired direction: Down
Direction: DownControl: 0.0314Healthy: 1.915e-04Effect: 0.0131Efficacy: 58.2883%BM Weight: 1Confidence: 1Weighted: 58.2883
58.29
◆ TNF-a
Tier 4 biomarker — desired direction: Down
Direction: DownControl: 18.3195Healthy: 0.221Effect: 7.4683Efficacy: 59.233%BM Weight: 1Confidence: 1Weighted: 59.233
59.23
◆ IL-6
Tier 4 biomarker — desired direction: Down
Direction: DownControl: 0.0314Healthy: 1.915e-04Effect: 0.0131Efficacy: 58.2883%BM Weight: 1Confidence: 1Weighted: 58.2883
58.29
◇
NLRP3 Signaling
1 biomarkers
0.00
›
◆ IL-1B
Tier 4 biomarker — desired direction: Down
Direction: DownControl: 3.6Healthy: 0.286Effect: 3.6Efficacy: 0%BM Weight: 1Confidence: 1Weighted: 0
0.00
✣
Muscle Atrophy
1 pathways
0.00
›
◇
Agrin Signaling
2 biomarkers
0.00
›
◆ MuRF1
Tier 4 biomarker — desired direction: Down
Direction: DownControl: 248.9186Healthy: 0Effect: 248.9186Efficacy: 0%BM Weight: 1Confidence: 1Weighted: 0
0.00
◆ MyHC
Tier 4 biomarker — desired direction: Up
Direction: UpControl: 0.158Healthy: 0.5Effect: 0.158Efficacy: 0%BM Weight: 1Confidence: 1Weighted: 0
0.00
✣
Neurodegeneration / ER Stress
2 pathways
0.00
›
◇
ER Stress / Calcium Dysregulation
1 biomarkers
0.00
›
◆ Ca2+
Tier 4 biomarker — desired direction: Down
Direction: DownControl: 1.997e+06Healthy: 2.000e+05Effect: 1.997e+06Efficacy: 0%BM Weight: 1Confidence: 1Weighted: 0
0.00
◇
FasL / Extrinsic Apoptosis
1 biomarkers
0.00
›
◆ FasL
Tier 4 biomarker — desired direction: Down
Direction: DownControl: 0.0364Healthy: 1.110e-03Effect: 0.0364Efficacy: 0%BM Weight: 1Confidence: 1Weighted: 0
0.00

Biomarker measurement matrix

Every Tier 4 biomarker tracked for Withanolide with control / healthy / effect levels

BiomarkerPathwayDirection ControlHealthyEffect Efficacy %Score (0–100)
IL-6 IL-6 Signaling Down 0.0314 1.915e-04 0.0131 58.2883 58.29
TNF-a IL-6 Signaling Down 18.3195 0.221 7.4683 59.233 59.23
IL-6 IL-6 Signaling Down 0.0314 1.915e-04 0.0131 58.2883 58.29
IL-1B NLRP3 Signaling Down 3.6 0.286 3.6 0 0.00
MuRF1 Agrin Signaling Down 248.9186 0 248.9186 0 0.00
MyHC Agrin Signaling Up 0.158 0.5 0.158 0 0.00
Ca2+ ER Stress / Calcium Dysregulation Down 1.997e+06 2.000e+05 1.997e+06 0 0.00
FasL FasL / Extrinsic Apoptosis Down 0.0364 1.110e-03 0.0364 0 0.00

References

Primary literature, source data, and methodology