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Berberine

Berberine is one of 22 compounds indexed in the ALS scoring workbook. It is measured against the 4-tier CytoSolve hierarchy: Tier 1 disease (Amyotrophic Lateral Sclerosis) → biological processes (3) → molecular pathways (5) → Tier 4 biomarkers (7). This page surfaces every measurement field from the workbook plus the source ingredients carrying this compound.

ALS Disease Rating
3.68
Interpretation
Minimal efficacy
Test Dosage
30 mg
Biomarker
7

Diseases this compound is indexed against

Tier 1 · macro-level biological phenomena

#1
Amyotrophic Lateral Sclerosis (ALS)
Lou Gehrig's disease · 3 processes · 5 pathways · 7 biomarkers
3.68

Ingredients containing Berberine

Whole-food and botanical sources of this compound · 3 ingredients

◇
Goldenseal
Source of Berberine · inherits 3.68/100 ALS rating
3.68
◇
Barberry
Source of Berberine · inherits 3.68/100 ALS rating
3.68
◇
Oregon Grape
Source of Berberine · inherits 3.68/100 ALS rating
3.68

Biological Processes · Pathways · Biomarkers

4-tier drill-down · click any node to expand the next tier

✣
Neuroinflammation
2 pathways
0.00
›
◇
IL-6 Signaling
2 biomarkers
0.00
›
◆ IL-6
Tier 4 biomarker — desired direction: Down
Direction: DownControl: 0.0314Healthy: 1.915e-04BM Weight: 1Confidence: 1
0.00
◆ TNF-a
Tier 4 biomarker — desired direction: Down
Direction: DownControl: 18.3195Healthy: 0.221BM Weight: 1Confidence: 1
0.00
◇
NLRP3 Signaling
1 biomarkers
0.00
›
◆ IL-1B
Tier 4 biomarker — desired direction: Down
Direction: DownControl: 3.6Healthy: 0.286BM Weight: 1Confidence: 1
0.00
✣
Muscle Atrophy
1 pathways
23.46
›
◇
Agrin Signaling
2 biomarkers
23.46
›
◆ MuRF1
Tier 4 biomarker — desired direction: Down
Direction: DownControl: 248.9186Healthy: 0Effect: 202Efficacy: 18.849%BM Weight: 1Confidence: 1Weighted: 18.849
18.85
◆ MyHC
Tier 4 biomarker — desired direction: Up
Direction: UpControl: 0.158Healthy: 0.5Effect: 0.169Efficacy: 6.929%BM Weight: 1Confidence: 1Weighted: 6.929
6.93
✣
Neurodegeneration / ER Stress
2 pathways
0.00
›
◇
ER Stress / Calcium Dysregulation
1 biomarkers
0.00
›
◆ Ca2+
Tier 4 biomarker — desired direction: Down
Direction: DownControl: 1.997e+06Healthy: 2.000e+05BM Weight: 1Confidence: 1
0.00
◇
FasL / Extrinsic Apoptosis
1 biomarkers
0.00
›
◆ FasL
Tier 4 biomarker — desired direction: Down
Direction: DownControl: 0.0364Healthy: 1.110e-03BM Weight: 1Confidence: 1
0.00

Biomarker measurement matrix

Every Tier 4 biomarker tracked for Berberine with control / healthy / effect levels

BiomarkerPathwayDirection ControlHealthyEffect Efficacy %Score (0–100)
IL-6 IL-6 Signaling Down 0.0314 1.915e-04 0.00
TNF-a IL-6 Signaling Down 18.3195 0.221 0.00
IL-1B NLRP3 Signaling Down 3.6 0.286 0.00
MuRF1 Agrin Signaling Down 248.9186 0 202 18.849 18.85
MyHC Agrin Signaling Up 0.158 0.5 0.169 6.929 6.93
Ca2+ ER Stress / Calcium Dysregulation Down 1.997e+06 2.000e+05 0.00
FasL FasL / Extrinsic Apoptosis Down 0.0364 1.110e-03 0.00

References

Primary literature, source data, and methodology