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Apigenin · Compound · GODS.com
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Apigenin

Apigenin is one of 22 compounds indexed in the ALS scoring workbook. It is measured against the 4-tier CytoSolve hierarchy: Tier 1 disease (Amyotrophic Lateral Sclerosis) → biological processes (3) → molecular pathways (5) → Tier 4 biomarkers (8). This page surfaces every measurement field from the workbook plus the source ingredients carrying this compound.

ALS Disease Rating
37.35
Interpretation
Low efficacy
Test Dosage
30 mg
Biomarker
8

Diseases this compound is indexed against

Tier 1 · macro-level biological phenomena

#1
Amyotrophic Lateral Sclerosis (ALS)
Lou Gehrig's disease · 3 processes · 5 pathways · 8 biomarkers
37.35

Ingredients containing Apigenin

Whole-food and botanical sources of this compound · 4 ingredients

◇
Parsley
Source of Apigenin · inherits 37.35/100 ALS rating
37.35
◇
Chamomile
Source of Apigenin · inherits 37.35/100 ALS rating
37.35
◇
Beetroot
Source of Apigenin · inherits 37.35/100 ALS rating
37.35
◇
Spinach
Source of Apigenin · inherits 37.35/100 ALS rating
37.35

Biological Processes · Pathways · Biomarkers

4-tier drill-down · click any node to expand the next tier

✣
Neuroinflammation
2 pathways
60.54
›
◇
IL-6 Signaling
3 biomarkers
57.70
›
◆ IL-6
Tier 4 biomarker — desired direction: Down
Direction: DownControl: 0.0314Healthy: 1.915e-04Effect: 0.0136Efficacy: 56.7106%BM Weight: 1Confidence: 1Weighted: 56.7106
56.71
◆ TNF-a
Tier 4 biomarker — desired direction: Down
Direction: DownControl: 18.3195Healthy: 0.221Effect: 7.7591Efficacy: 57.6457%BM Weight: 1Confidence: 1Weighted: 57.6457
57.65
◆ IL-6
Tier 4 biomarker — desired direction: Down
Direction: DownControl: 0.0314Healthy: 1.915e-04Effect: 0.0136Efficacy: 56.7106%BM Weight: 1Confidence: 1Weighted: 56.7106
56.71
◇
NLRP3 Signaling
1 biomarkers
63.37
›
◆ IL-1B
Tier 4 biomarker — desired direction: Down
Direction: DownControl: 3.6Healthy: 0.286Effect: 1.5Efficacy: 58.3333%BM Weight: 1Confidence: 1Weighted: 58.3333
58.33
✣
Muscle Atrophy
1 pathways
23.56
›
◇
Agrin Signaling
2 biomarkers
23.56
›
◆ MuRF1
Tier 4 biomarker — desired direction: Down
Direction: DownControl: 248.9186Healthy: 0Effect: 201.8058Efficacy: 18.927%BM Weight: 1Confidence: 1Weighted: 18.927
18.93
◆ MyHC
Tier 4 biomarker — desired direction: Up
Direction: UpControl: 0.158Healthy: 0.5Effect: 0.2371Efficacy: 50.0394%BM Weight: 1Confidence: 1Weighted: 50.0394
50.04
✣
Neurodegeneration / ER Stress
2 pathways
0.25
›
◇
ER Stress / Calcium Dysregulation
1 biomarkers
0.16
›
◆ Ca2+
Tier 4 biomarker — desired direction: Down
Direction: DownControl: 1.997e+06Healthy: 2.000e+05Effect: 1.994e+06Efficacy: 0.1421%BM Weight: 1Confidence: 1Weighted: 0.1421
0.14
◇
FasL / Extrinsic Apoptosis
1 biomarkers
0.33
›
◆ FasL
Tier 4 biomarker — desired direction: Down
Direction: DownControl: 0.0364Healthy: 1.110e-03Effect: 0.0362Efficacy: 0.3236%BM Weight: 1Confidence: 1Weighted: 0.3236
0.32

Biomarker measurement matrix

Every Tier 4 biomarker tracked for Apigenin with control / healthy / effect levels

BiomarkerPathwayDirection ControlHealthyEffect Efficacy %Score (0–100)
IL-6 IL-6 Signaling Down 0.0314 1.915e-04 0.0136 56.7106 56.71
TNF-a IL-6 Signaling Down 18.3195 0.221 7.7591 57.6457 57.65
IL-6 IL-6 Signaling Down 0.0314 1.915e-04 0.0136 56.7106 56.71
IL-1B NLRP3 Signaling Down 3.6 0.286 1.5 58.3333 58.33
MuRF1 Agrin Signaling Down 248.9186 0 201.8058 18.927 18.93
MyHC Agrin Signaling Up 0.158 0.5 0.2371 50.0394 50.04
Ca2+ ER Stress / Calcium Dysregulation Down 1.997e+06 2.000e+05 1.994e+06 0.1421 0.14
FasL FasL / Extrinsic Apoptosis Down 0.0364 1.110e-03 0.0362 0.3236 0.32

References

Primary literature, source data, and methodology