licorice - Gods

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Licorice

Ingredient · 14 compounds · 6 conditions

Licorice is profiled across the CytoSolve® knowledge base and mapped to the disease biology it influences — tracing each of its compounds through disease, biological process, molecular pathway and down to individual biomarkers, with source videos and references at each step.

Compounds in this ingredient

⌬18β-Glycyrrhetinic Acid ⌬Formononetin ⌬Glabridin ⌬Glycyrrhetic Acid ⌬Glycyrrhetinic Acid ⌬Glycyrrhizic Acid ⌬Glycyrrhizin ⌬Isoliquiritigenin ⌬Licochalcone A ⌬Licochalcone A/B ⌬Licochalcone B ⌬Licochalcone E ⌬Liquiritigenin ⌬Liquiritin

Conditions addressed

❀Alzheimer's Disease ❀Asthma ❀Bowel Health ❀Gut-Brain Health ❀Liver Health ❀Viral Infections

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Ingredient → Compounds → Diseases → Biological Processes → Molecular Pathways → Biomarkers

All Compound Disease Biological Process Molecular Pathway

⌬

Compound · 5 disease(s) · 7 pathway(s)

▸

❀

Alzheimer's Disease

Disease · 1 process(es) · 1 pathway(s)

▸

▸✣ NeuroInflammation1 pathway

▸▣ HMGB-1/TLR4/NF-κB Signaling

◈ TargetHMGB-1

◆IL-1β, IL-6, and TNF-α

❀

Viral Infections

Disease · 2 process(es) · 2 pathway(s)

▸

▸✣ Inflammation1 pathway

▸▣ M1-M2 Polarization Signaling

◈ TargetIL-25

◆IL-10

▸✣ Oxidative Stress1 pathway

▸▣ Nrf2 Signaling

◈ TargetHMGB-1

◆HO-1

❀

Disease · 1 process(es) · 1 pathway(s)

▸

▸✣ Oxidative Stress1 pathway

▸▣ Nrf2 Signaling

◈ TargetHMGB-1

◆HO-1, GPX4

❀

Disease · 1 process(es) · 1 pathway(s)

▸

▸✣ Inflammation1 pathway

▸▣ HMGB-1/TLR4 Signalling

◈ TargetHMGB-1

◆TNF‐α, IL‐1β and IL‐6

❀

Gut-Brain Health

Disease · 2 process(es) · 2 pathway(s)

▸

▸✣ Inflammation1 pathway

▸▣ HMGB-1/TLRs/NF-κB Signaling

◈ TargetHMGB-1

◆TNF-α, IL-1β, and IL-6

▸✣ Oxidative Stress1 pathway

▸▣ NRF2 Signaling

◈ TargetNrf2

◆GPX4, ROS

⌬

Compound · 1 disease(s) · 1 pathway(s)

▸

❀

Alzheimer's Disease

Disease · 1 process(es) · 1 pathway(s)

▸

▸✣ NeuroInflammation1 pathway

▸▣ M1 Polarization Signaling

◈ TargetCholine Transporter-Like 1 (CTL1)

◆TNF-α

⌬

Licochalcone A/B

Compound · 1 disease(s) · 1 pathway(s)

▸

❀

Alzheimer's Disease

Disease · 1 process(es) · 1 pathway(s)

▸

▸✣ NeuroInflammation1 pathway

▸▣ Amyloidogenic pathway

◈ TargetAß aggregation

◆Aß aggregates

⌬

Glycyrrhizic Acid

Compound · 1 disease(s) · 1 pathway(s)

▸

❀

Viral Infections

Disease · 1 process(es) · 1 pathway(s)

▸

▸✣ Inflammation1 pathway

▸▣ IgE Signaling

◈ TargetHistamine

◆IL-4

⌬

Compound · 1 disease(s) · 1 pathway(s)

▸

❀

Disease · 1 process(es) · 1 pathway(s)

▸

▸✣ Inflammation1 pathway

▸▣ LPS/TLR4 Signaling

◈ TargetNF-κB

◆TNF-α and IL-1β

⌬

18β-Glycyrrhetinic Acid

Compound · 2 disease(s) · 3 pathway(s)

▸

❀

Disease · 1 process(es) · 1 pathway(s)

▸

▸✣ Inflammation1 pathway

▸▣ IL-17 Signaling

◈ TargetRORYT

◆IL-17, RORYT

▶ Video ❀ Reference

❀

Disease · 2 process(es) · 2 pathway(s)

▸

▸✣ Oxidative Stress1 pathway

▸▣ Nrf2 Signaling

◈ TargetNrf2

◆ROS

▸✣ Inflammation1 pathway

▸▣ NF-κB Signaling

◈ TargetNF-κB

◆iNOS

⌬

Isoliquiritigenin

Compound · 4 disease(s) · 6 pathway(s)

▸

❀

Disease · 2 process(es) · 2 pathway(s)

▸

▸✣ Epithelial-Mesenchymal Transition1 pathway

▸▣ TGF-β Signaling

◈ TargetTGF-β

◆Collagen & α-SMA

▶ Video ❀ Reference

▸✣ Inflammation1 pathway

▸▣ LPS Signaling

◈ TargetNF-κB◈ TargetPPAR-γ

◆TNF-α, IL-1β, and IL-6

❀

Viral Infections

Disease · 2 process(es) · 2 pathway(s)

▸

▸✣ Neuroinflammation1 pathway

▸▣ NF-κB Signaling

◈ TargetNF-κB p65

◆TNF-α, IL-6, IL-1β, iNOS, COX-2

▸✣ Oxidative Stress1 pathway

▸▣ Nrf2 Signaling

◈ TargetNrf2

◆Nrf2, HO-1, NQO1

❀

Disease · 1 process(es) · 1 pathway(s)

▸

▸✣ Oxidative Stress1 pathway

▸▣ Nrf2 Signaling

◈ TargetNrf2

◆ROS

❀

Gut-Brain Health

Disease · 1 process(es) · 1 pathway(s)

▸

▸✣ Inflammation1 pathway

▸▣ LPS Signaling

◈ TargetNF-κB

◆TNF-α and IL-6

⌬

Glycyrrhetic Acid

Compound · 1 disease(s) · 1 pathway(s)

▸

❀

Disease · 1 process(es) · 1 pathway(s)

▸

▸✣ Inflammation1 pathway

▸▣ LPS/TLR4 Signaling

◈ TargetNF-κB

◆IL-1β, IL-18, TNF-α, and IL-6

▶ Video ❀ Reference

◈ TargetNF-κB

◆Claudin-1, Occludin, ZO-1

▶ Video ❀ Reference

⌬

Compound · 4 disease(s) · 6 pathway(s)

▸

❀

Viral Infections

Disease · 2 process(es) · 3 pathway(s)

▸

▸✣ Oxidative Stress2 pathways

▸▣ Nrf2 Signaling

◈ TargetKeap1◈ TargetLC3/P62

◆ROS

▸▣ PI3K/AKT/p53 Signaling

◈ TargetAKR1B1

◆ROS

▸✣ Inflammation1 pathway

▸▣ MAPK Signaling

◈ TargetMAPK

◆IL-1β, IL-4, IL-6, IL-8, IL-13, TNFα, INF γ

❀

Disease · 1 process(es) · 1 pathway(s)

▸

▸✣ Oxidative Stress1 pathway

▸▣ Nrf2 Signaling

◈ TargetNrf2

◆ROS

❀

Disease · 1 process(es) · 1 pathway(s)

▸

▸✣ Inflammation1 pathway

▸▣ cAMP Signaling

◈ TargetAdenylyl Cyclase (AC)

◆cAMP Level

❀

Gut-Brain Health

Disease · 1 process(es) · 1 pathway(s)

▸

▸✣ Depression1 pathway

▸▣ PI3K/AKT Signaling

◈ TargetPI3K

◆BDNF

⌬

Compound · 4 disease(s) · 7 pathway(s)

▸

❀

Viral Infections

Disease · 4 process(es) · 4 pathway(s)

▸

▸✣ Metastasis1 pathway

▸▣ TGF-β/SMAD Signaling

◈ TargetmiR-148a

◆miR-148a

▸✣ Apoptosis1 pathway

▸▣ Glycolytic pathway

◈ TargetGLUT-1

◆BAX/BCL-2

▸✣ Cell Proliferation1 pathway

▸▣ PI3K/AKT Signaling

◈ TargetAKT

◆p-AKT

▸✣ Angiogenesis1 pathway

▸▣ Wnt/β-catenin Signaling

◈ TargetWnt

◆cyclinD1, MMP-2

❀

Disease · 1 process(es) · 1 pathway(s)

▸

▸✣ Oxidative Stress1 pathway

▸▣ CYP2E1-mediated Oxidative Stress Signaling

◈ TargetCYP2E1

◆MDA, GSH, SOD, CAT, ALT, AST

❀

Disease · 1 process(es) · 1 pathway(s)

▸

▸✣ Platelet Aggregation1 pathway

▸▣ PI3K/AKT/GSK3ß Signaling

◈ TargetPLCγ2◈ TargetNF-κB

◆P-selectin

❀

Gut-Brain Health

Disease · 1 process(es) · 1 pathway(s)

▸

▸✣ Anxiousness1 pathway

▸▣ GABA Signaling

◈ TargetGABAA Receptor

◆GABAA Receptor

⌬

Glycyrrhetinic Acid

Compound · 1 disease(s) · 2 pathway(s)

▸

❀

Viral Infections

Disease · 1 process(es) · 2 pathway(s)

▸

▸✣ Apoptosis2 pathways

▸▣ Oxidative Stress Signaling

◈ TargetPRDX1◈ TargetPRDX2

◆ROS

▸▣ Cx43/JNK/NF-κB Signaling

◈ TargetCx43

◆BAX/BCL-2

⌬

Compound · 2 disease(s) · 3 pathway(s)

▸

❀

Viral Infections

Disease · 2 process(es) · 2 pathway(s)

▸

▸✣ Oxidative Stress1 pathway

▸▣ Nrf2 Signaling

◈ TargetNrf2◈ TargetKeap1

◆SOD,CAT, GPx, 8-Oxo-dG

▸✣ Inflammation1 pathway

▸▣ Nrf2 Signaling

◈ TargetNrf2

◆IL-1β, MCP1, CXCL10, Arg1, CD163

❀

Gut-Brain Health

Disease · 1 process(es) · 1 pathway(s)

▸

▸✣ Oxidative Stress1 pathway

▸▣ NRF2 Signaling

◈ TargetNrf2

◆HO-1

⌬

Compound · 2 disease(s) · 2 pathway(s)

▸

❀

Disease · 1 process(es) · 1 pathway(s)

▸

▸✣ Oxidative Stress1 pathway

▸▣ Nrf2 Signaling

◈ TargetNrf2

◆ROS

❀

Gut-Brain Health

Disease · 1 process(es) · 1 pathway(s)

▸

▸✣ Inflammation1 pathway

▸▣ Arachidonic Acid Signaling

◈ TargetPGE2

◆PGE2, COX, IL-6, TNFα

⌬

Compound · 1 disease(s) · 2 pathway(s)

▸

❀

Disease · 1 process(es) · 2 pathway(s)

▸

▸✣ Inflammation2 pathways

▸▣ LPS Signaling

◈ TargetTRPV1◈ TargetTRPA1 Channel

◆MPO, TNF-α, IL-1β, and IL-6

▸▣ LPS/TLR Signaling

◈ Targetp-JNK

◆TNF-α, and IL-6