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Piperine
Compound · in 2 ingredients · 6 conditions

Piperine is tracked across every ingredient that carries it and mapped to the disease biology it modulates, resolving down to molecular targets and biomarkers with linked evidence.

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Comparison

All Disease Biological Process Molecular Pathway
Disease · 3 process(es) · 3 pathway(s)
NeuroInflammation1 pathway
LPS/TLR4 Signaling
◈ TargetNF-κB♧ IngredientBlack Pepper
IL-1β, IL-6, and TNF-α
Oxidative Stress1 pathway
Nrf2/ARE Signaling
◈ TargetROS♧ IngredientBlack Pepper
ROS
Neurodegeneration1 pathway
Caspase-3 Signaling
◈ TargetBax♧ IngredientBlack Pepper
BAX, Caspase-3
Disease · 3 process(es) · 5 pathway(s)
Inflammation3 pathways
STAT6/GATA3/IL-4 Signaling
◈ TargetSTAT6♧ IngredientBlack Pepper
TNF-α and IL-1β
Th2/Th17 Signaling
◈ TargetMast cell activation♧ IngredientBlack Pepper
IL-4, IL-6, IL-1β, IL-17A, and TNF-α
IL1β Signaling
◈ TargetAP-1♧ IngredientLong Pepper
IL6, COX-2, PGE-2
Apoptosis1 pathway
Oxidative Stress Signaling
◈ TargetMitochondrial complex III◈ TargetNADPH Oxidase◈ TargetXanthine Oxidase♧ IngredientLong Pepper
Cleaved PARP
Cartilage Degeneration1 pathway
IL1β Signaling
◈ TargetERK1/2♧ IngredientLong Pepper
MMP1, MMP13
Disease · 2 process(es) · 3 pathway(s)
Cholesterol Elimination2 pathways
Cholesterol homeostasis Signaling
◈ TargetCholesterol 7α-hydroxylase (CYP7A1)♧ IngredientBlack Pepper
TG, LDL, Bile acid, Cholesterol
LDL Signaling
◈ TargetLecithin-cholesterol acyltransferase (LCAT)♧ IngredientBlack Pepper
TG, LDL, Bile acid, Cholesterol
Lipid Peroxidation1 pathway
ROS Signaling
◈ TargetROS♧ IngredientBlack Pepper
MDA, ROS, Ox-LDL
Disease · 4 process(es) · 4 pathway(s)
Fat Digestion1 pathway
Lipid Metabolic Signaling
◈ TargetPancreatic and intestinal Lipase♧ IngredientBlack Pepper
Lipase, Triglycerides
Carbohydrate Digestion1 pathway
Carbohydrate Metabolic Signaling
◈ TargetSalivary and pancreatic α-amylase♧ IngredientBlack Pepper
Dietary Carbohydrate, monosaccharides, α-amylase
Protein Digestion1 pathway
Protein Metabolic Signaling
◈ TargetPepsin, Trypsin, Chymotrypsin♧ IngredientBlack Pepper
Dietary Protein, Pepsin, Trypsin, Chymotrypsin
Inflammation1 pathway
NF-κB Signaling
◈ TargetNF-κB♧ IngredientLong Pepper
TNF-α, COX-2, claudin-1, occludin, and ZO-1
Disease · 2 process(es) · 2 pathway(s)
Fibrosis1 pathway
TGF-β/SMAD Signaling
◈ Targetp-SMAD2♧ IngredientLong Pepper
N-cadherin, Fibronectin, MMP-2
Inflammation1 pathway
NF-κB Signaling
◈ TargetIKK Complex♧ IngredientBlack Pepper
TNF-α, IL-6, IL-1β
Disease · 1 process(es) · 1 pathway(s)
Inflammation1 pathway
IL-1β Signaling
◈ TargetIκBα◈ TargetNF-κB♧ IngredientBlack Pepper♧ IngredientLong Pepper
MMP-3, MMP-13, iNOS and COX-2