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Diabetes
Disease / Phenomenon
A metabolic disorder in which the body struggles to regulate blood glucose, whether from insufficient insulin or reduced insulin sensitivity, straining vessels, nerves, and organs over time.
Biological Processes of Diabetes
Explore the key biological processes that drive diabetes, from cellular mechanisms through tissue-level responses.
Hyperglycemia
12 pathway(s)
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Hyperglycemia
12 pathway(s)
GLUT-2 Signaling
Target: Na+ glucose symporter
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GLUT-2 Signaling
Target: Na+ glucose symporter
Glucose
IRS1/FOXO1 Signaling
Target: Incretins, Gastric inhibitory polypeptide (GIP) and Glucagon-like peptide 1 (GLP 1)
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IRS1/FOXO1 Signaling
Target: Incretins, Gastric inhibitory polypeptide (GIP) and Glucagon-like peptide 1 (GLP 1)
Insulin Signaling
Target: GLP-1
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Insulin Signaling
Target: GLP-1
Glucose
AKT Signaling
Target: AKT
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AKT Signaling
Target: AKT
Glucose
GLUT-4 signalling
Target: GLUT-4
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GLUT-4 signalling
Target: GLUT-4
Glucose
PI3K/AKT/GLUT4 Signaling
Target: PI3K
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PI3K/AKT/GLUT4 Signaling
Target: PI3K
Glucose
AMPK/FOXO1 Signaling
Target: AMPK
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AMPK/FOXO1 Signaling
Target: AMPK
Glucose
AKT/GSK-3β Signaling
Target: AKT
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AKT/GSK-3β Signaling
Target: AKT
Glucose
PTP1B/Glut-4 Signaling
Target: Glut-4
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PTP1B/Glut-4 Signaling
Target: Glut-4
Glut-4
PPAR-γ/Glut-4 Signaling
Target: Glut-4
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PPAR-γ/Glut-4 Signaling
Target: Glut-4
Glut-4
Inflammation
2 pathway(s)
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Inflammation
2 pathway(s)
NF-κB Signaling
Target: NF-κB
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NF-κB Signaling
Target: NF-κB
TNF-α and IL -6
Arachidonic Acid Signaling
Target: PGE-2
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Arachidonic Acid Signaling
Target: PGE-2
PGE-2
Oxidative Stress
3 pathway(s)
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Oxidative Stress
3 pathway(s)
Insulin secretion
1 pathway(s)
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Insulin secretion
1 pathway(s)
GLP-1 Signaling
Target: TAS2R
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GLP-1 Signaling
Target: TAS2R
Insulin
Compounds affecting Diabetes
Browse active compounds and their direct impact on diabetes biological processes, pathways, and biomarkers.
Ingredients affecting Diabetes
Explore therapeutic ingredients and their constituent compounds that modulate diabetes biology.
1 active compound(s)
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1 active compound(s)
Hyperglycemia → IRS/AKT/GLUT4 Signaling
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Hyperglycemia → IRS/AKT/GLUT4 Signaling
1 active compound(s)
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1 active compound(s)
2 active compound(s)
▸
2 active compound(s)
Hyperglycemia → Insulin Signaling
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Hyperglycemia → Insulin Signaling
Glucose
Hyperglycemia → AKT Signaling
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Hyperglycemia → AKT Signaling
Glucose
1 active compound(s)
▸
1 active compound(s)
Insulin Resistance → NF-κB Signaling
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Insulin Resistance → NF-κB Signaling
3 active compound(s)
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3 active compound(s)
Hyperglycemia → PTP1B/Glut-4 Signaling
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Hyperglycemia → PTP1B/Glut-4 Signaling
Glut-4
Inflammation → Arachidonic Acid Signaling
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Inflammation → Arachidonic Acid Signaling
PGE-2
Oxidative Stress → Nrf2/Keap Signaling
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Oxidative Stress → Nrf2/Keap Signaling
0 active compound(s)
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0 active compound(s)
2 active compound(s)
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2 active compound(s)
Hyperglycemia → PI3K/AKT/GLUT4 Signaling
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Hyperglycemia → PI3K/AKT/GLUT4 Signaling
Glucose
1 active compound(s)
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1 active compound(s)
Hyperglycemia → GLUT-2 Signaling
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Hyperglycemia → GLUT-2 Signaling
Glucose
0 active compound(s)
▸
0 active compound(s)
1 active compound(s)
▸
1 active compound(s)
Inflammation → NF-κB Signaling
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Inflammation → NF-κB Signaling
TNF-α and IL -6
1 active compound(s)
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1 active compound(s)