Compound Page · ALS Indexed
Beta Sitosterol
Beta Sitosterol is one of 22 compounds indexed in the ALS scoring workbook. It is measured against the 4-tier CytoSolve hierarchy: Tier 1 disease (Amyotrophic Lateral Sclerosis) → biological processes (3) → molecular pathways (5) → Tier 4 biomarkers (7). This page surfaces every measurement field from the workbook plus the source ingredients carrying this compound.
ALS Disease Rating
2.66
Interpretation
Minimal efficacy
Test Dosage
160 mg
Biomarker
7
Diseases this compound is indexed against
Tier 1 · macro-level biological phenomena
Ingredients containing Beta Sitosterol
Whole-food and botanical sources of this compound · 3 ingredients
◇
Pumpkin Seeds
Source of Beta Sitosterol · inherits 2.66/100 ALS rating
2.66
◇
Pecans
Source of Beta Sitosterol · inherits 2.66/100 ALS rating
2.66
◇
Wheat Germ
Source of Beta Sitosterol · inherits 2.66/100 ALS rating
2.66
Biological Processes · Pathways · Biomarkers
4-tier drill-down · click any node to expand the next tier
✣
Neuroinflammation
2 pathways
0.00
›
Neuroinflammation
2 pathways
◇
IL-6 Signaling
2 biomarkers
0.00
›
IL-6 Signaling
2 biomarkers
◆ IL-6
Tier 4 biomarker — desired direction: Down
Direction: DownControl: 0.0314Healthy: 1.915e-04BM Weight: 1Confidence: 1
0.00
◆ TNF-a
Tier 4 biomarker — desired direction: Down
Direction: DownControl: 18.3195Healthy: 0.221BM Weight: 1Confidence: 1
0.00
◇
NLRP3 Signaling
1 biomarkers
0.00
›
NLRP3 Signaling
1 biomarkers
◆ IL-1B
Tier 4 biomarker — desired direction: Down
Direction: DownControl: 3.6Healthy: 0.286BM Weight: 1Confidence: 1
0.00
✣
Muscle Atrophy
1 pathways
3.00
›
Muscle Atrophy
1 pathways
◇
Agrin Signaling
2 biomarkers
3.00
›
Agrin Signaling
2 biomarkers
◆ MuRF1
Tier 4 biomarker — desired direction: Down
Direction: DownControl: 248.9186Healthy: 0Effect: 234Efficacy: 5.9934%BM Weight: 1Confidence: 1Weighted: 5.9934
5.99
◆ MyHC
Tier 4 biomarker — desired direction: Up
Direction: UpControl: 0.158Healthy: 0.5Effect: 0.178Efficacy: 12.6234%BM Weight: 1Confidence: 1Weighted: 12.6234
12.62
✣
Neurodegeneration / ER Stress
2 pathways
0.00
›
Neurodegeneration / ER Stress
2 pathways
◇
ER Stress / Calcium Dysregulation
1 biomarkers
0.00
›
ER Stress / Calcium Dysregulation
1 biomarkers
◆ Ca2+
Tier 4 biomarker — desired direction: Down
Direction: DownControl: 1.997e+06Healthy: 2.000e+05BM Weight: 1Confidence: 1
0.00
◇
FasL / Extrinsic Apoptosis
1 biomarkers
0.00
›
FasL / Extrinsic Apoptosis
1 biomarkers
◆ FasL
Tier 4 biomarker — desired direction: Down
Direction: DownControl: 0.0364Healthy: 1.110e-03BM Weight: 1Confidence: 1
0.00
Biomarker measurement matrix
Every Tier 4 biomarker tracked for Beta Sitosterol with control / healthy / effect levels
| Biomarker | Pathway | Direction | Control | Healthy | Effect | Efficacy % | Score (0–100) |
|---|---|---|---|---|---|---|---|
| IL-6 | IL-6 Signaling | Down | 0.0314 | 1.915e-04 | 0.00 | ||
| TNF-a | IL-6 Signaling | Down | 18.3195 | 0.221 | 0.00 | ||
| IL-1B | NLRP3 Signaling | Down | 3.6 | 0.286 | 0.00 | ||
| MuRF1 | Agrin Signaling | Down | 248.9186 | 0 | 234 | 5.9934 | 5.99 |
| MyHC | Agrin Signaling | Up | 0.158 | 0.5 | 0.178 | 12.6234 | 12.62 |
| Ca2+ | ER Stress / Calcium Dysregulation | Down | 1.997e+06 | 2.000e+05 | 0.00 | ||
| FasL | FasL / Extrinsic Apoptosis | Down | 0.0364 | 1.110e-03 | 0.00 |
References
Primary literature, source data, and methodology
- PubMed: "Beta Sitosterol ALS" — peer-reviewed literature search
- Wikipedia: Beta Sitosterol — chemical structure, biosynthesis, mechanism
- Open Science Institute — 29 published research papers on CytoSolve methodology
- OSI · ALS Web-Enabled Systems Architecture (parent disease model)
- CytoSolve® — computational modelling platform powering this scoring
- C.L.E.A.N. Food Certified — clean-source verification standard